Brain

August's issue of Brain is now online! academic.oup.com/brain/issue/...

Yogeshwar et al. present clinical and MRI data from 127 patients with anti-IgLON5 disease. They show brain atrophy patterns that closely mirror sites of autoantibody binding and tau accumulation, with the location of atrophy linked to specific symptoms. tinyurl.com/3u4ufv2z

Peruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts, and show that iNSCs can differentiate into mature oligodendrocytes and remyelinate axons in demyelinated lesions. tinyurl.com/3a2auah5

Disentangling epilepsy and dementia: more to do, together

New scientific commentary by Arjune Sen tinyurl.com/mr44jt9b

Seeing the trees in the wood: the importance of co-pathologies in Alzheimer’s disease and dementia with Lewy bodies Our understanding of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) owes a debt to pioneering work by Emil Kraepelin, Franz Nissl, Alois Alzh

I’m delighted to share my editorial for the July issue @brain1878.bsky.social academic.oup.com/brain/articl...

Benninger & Goldberg argue that early surgery for lesional focal epilepsy should be considered even before the emergence of drug resistance. tinyurl.com/3b7msy45

Medial temporal lobe structural changes when Down syndrome and Alzheimer’s disease collide

New scientific commentary by Laura Wisse and Renaud La Joie tinyurl.com/345u5r3w

The converging paths to hippocampal sclerosis of ageing: insights from LATE-NC and vascular disease

New scientific commentary by Ryan Coburn and Hugo Botha tinyurl.com/3ffhrkm7

Kazazian et al. review the use of neuroimaging in disorders of consciousness, detailing key methods (fMRI, EEG, PET) and imaging paradigms that can be used to improve diagnosis and prognosis. tinyurl.com/bddyanm4

Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome Anand et al. show that Alzheimer's disease risk genes confer vulnerability or resilience to tau pathology through both network-dependent and independent me

In a NEW STUDY, researchers Chaitali Anand, Justin Torok,, Ashish Raj, et al. at UCSF reveal how genes influence where & how #Alzheimers - related tau protein spreads in the brain. Learn More @brain1878.bsky.social academic.oup.com/brain/advanc...

Benninger & Goldberg argue that early surgery for lesional focal epilepsy should be considered even before the emergence of drug resistance. tinyurl.com/3b7msy45

Proelss et al. describe the mapping of human genital representations by electrical stimulation of somatosensory cortex. Males but not females report genital sensations in response to stimulation of the postcentral gyrus. tinyurl.com/2xptrtfs

Moschovaki-Filippidou et al. show that an exon skipping morpholino targeting Dnm2 splicing reduces intact Dmn2 mRNA and protein levels in muscle, and restores muscle force, in a centronuclear myopathy mouse model. tinyurl.com/3hth9csf

Graham et al. used biomarkers to investigate the effects of TBI in mid-life former elite rugby players. Compared to unexposed controls, these individuals showed elevated plasma p-tau217 levels and reduced volumes in frontal and anterior cingulate cortex. tinyurl.com/j8emw6d3

Pathogenic variants in CLCN3 and CLCN4—which encode the 2Cl-/H+ exchangers ClC-3 and ClC-4—cause rare neurodevelopmental disorders. Qi et al. show that ClC-3/ClC-4 regulate neuronal excitability and firing patterns by fine-tuning Kv7/KCNQ channel density. tinyurl.com/2tbpdevh

July's issue of Brain is now online! academic.oup.com/brain/issue/...

TDP-43 aggregates play a key role in nerve cell loss in ALS and FTD. Ervilha Pereira et al. highlight new genetic data showing that TDP-43 also plays a role in muscle function and disease. tinyurl.com/2uy95axn

Sun et al. generate a transcriptomic map of the developing human leptomeninges by analysing more than 27 000 single-cell transcriptomes from tissues spanning different fetal stages. tinyurl.com/3z7cj7pc

Bellanti et al. have developed an ultrasensitive assay for periaxin, a biomarker of peripheral nerve demyelination. When used alongside existing tests, the assay has the potential to improve the clinical management of peripheral neuropathy. tinyurl.com/4rbwjh67

Chen et al. present a composite model that uses genetic and microRNA markers to differentiate patients with migraine from controls, and to distinguish between the ictal and interictal phases of migraine. tinyurl.com/4dd8e5vv

Ketamine can alleviate depressive symptoms within hours, with the effects of a single dose lasting for days. Costi et al. review the mechanisms underlying the rapid antidepressant effects of ketamine in humans and animal models. tinyurl.com/mtwy2s4f

Using cellular models of human brain development, Benoit et al. show that POU3F2 – a transcription factor implicated in neurodevelopmental disorders – enhances canonical Wnt signalling. tinyurl.com/3s94ra2u

The dystonin gene encodes three major isoforms: DST-a, -b, and -e. Jacob et al. report that variants exclusively affecting DST-b cause an autosomal recessive congenital myopathy, while variants that also affect DST-a cause a lethal contracture syndrome. tinyurl.com/3p99pu9j

Maroni et al. show that partial loss of the histone lysine methyltransferase DOT1L disrupts synaptic gene transcription, alters neuronal morphology, and leads to sex-specific deficits in social behaviour. tinyurl.com/3ub4krn6

Benacom et al. show that transient disruption of perineuronal nets in primary motor cortex temporarily impairs motor function in healthy mice, but facilitates motor recovery in a Parkinson’s disease model. tinyurl.com/b7kaba4t

Hvingelby et al. show that reduced cholinergic activity in locomotor-related areas of the brainstem is associated with more severe freezing of gait in people with Parkinson’s disease, but only when they are in the ON motor state. tinyurl.com/yjwrmkjc

He et al. recorded neural activity from the motor cortex and thalamus, along with hand tremor signals, in people with essential tremor. Their findings provide new insights into the cortico-thalamic network involved in tremor generation. tinyurl.com/4b3ppah2

Using post-mortem in situ MRI, Wesseling et al. show that brain donors with LATE-NC have lower amygdalar and hippocampal volumes than non-LATE-NC donors, even when correcting for regional phosphorylated tau, amyloid-beta, and alpha-synuclein. tinyurl.com/34p435bd

Yang et al. propose that psychedelics hold untapped potential for improving stroke recovery through their ability to modulate neuroplasticity, reduce neuroinflammation, and enhance cognitive and psychological resilience. tinyurl.com/mzcvjyn

Drawing on two decades of clinical experience with affective disorders, Jesús Ramírez-Bermúdez— runner up in the Brain Essay Competition—explores the cultural significance of melancholy. tinyurl.com/4tmw6buk