Nathan Gamarra Ph.D.

RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations.
www.nature.com/articles/s41...

XPG's interaction with TFIIH's p62 & XPD through its spacer region is key for completing UV and chemo-induced DNA repair. Essential NER insight! PMID:41641700, Nucleic Acids Res 2026, @NAR_Open https://doi.org/10.1093/nar/gkag078 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A detailed digital composite image based on the 1947 historical photograph of geneticist Barbara McClintock. McClintock, with her characteristic short hair and round glasses, is seated at a microscope, using tweezers in a Petri dish. While based on the original photo distributed for her AAUW award, this image presents a significantly expanded and fictionalized laboratory environment. The simple wooden workbench is now densely populated with a vast, colorized collection of complex glassware, numerous amber-colored reagent bottles, intricate distillation columns, and botanical specimens relevant to maize cytogenetics, creating a rich, illustrative narrative of her "jumping gene" research context that was not present in the original photo. The expanded background shows complex vintage laboratory cabinetry. This image explicitly states it is a composite: a digital recreation where Seriously Scientific has taken the historical figure and placed them into an augmented, complex fictionalized environment. Based on original source from Smithsonian Institution Archives. Digital composite by Seriously Scientific.

Remembering Barbara McClintock on International Women's Day!
She discovered that genes aren't static, they can actually "jump" around on a chromosome.

Her discovery of transposons ("jumping genes") fundamentally changed how we understand evolution and the complexity of DNA! 🧬🌽

#WomenInScience

So much online conservatism these days is just "I miss being a kid"

Re-upping this post from a year ago. To invest in basic research is to invest in a better future for everyone.

You know, everyone deserves a better future, not just billionaires or whoever owns stocks of AI companies.

Meet three scientists who said no to Epstein The warning signs included a web search, a mother’s doubts, and inklings of a “sexist attitude”

“Academics tend to have this way of interacting with people that works really well when there is mutual good faith,” Aaronson says. “But it breaks down when that doesn’t exist. And I think a lot of academics were just not prepared to deal with someone like him.”

www.science.org/content/arti...

Fred Hutchinson Cancer Center Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

My awesome colleague, @yarimura.bsky.social, is recruiting a postdoc to start at the end of 2026 or early 2027! His lab uses cryo-EM to uncover structural basis of key chromatin events using native complexes isolated from human cells or Xenopus egg extracts!

careers-fhcrc.icims.com/jobs/30706/p...

Where should SocArXiv draw the AI line? A case that helps sort out the questions for an AI policy at SocArXiv.

Where do we draw the line in AI use for manuscript writing? 🧪 socopen.org/2026/02/22/w...

“In 1 of the simulations, 8x out of 10 (84%), the platform sent a suffocating woman to a future appt she would not live to see… Meanwhile, 64.8% of completely safe individuals were told to seek immediate medical care.”

“40 million+ people reportedly ask ChatGPT for health-related advice every day”🧪

The Constructor Theory of Life Why Intelligent Design is wrong and how life constructs itself

🧪 Please check out my new article titled- The Constructor Theory of Life- Why Intelligent Design is wrong and how life builds itself.
It's on Medium, access using the link below:
medium.com/science-spec...

#science #philsky #philosophy #biology

Complex Peaks #Chemsky #ChemChat 🧪

The spice must flow!

In a first, researchers film treetops glowing during thunderstorms Glimmer sparked by electrical fields detected in nature for the first time

“The researchers caught a twinkling surrounding the tips of leaves at ultraviolet (UV) wavelengths. They hope the work will shed light on how thunderstorms electrify the landscape and produce lightning.”

#scicomm

www.science.org/content/arti...
🧪

I wonder if there could have been hybrid sterility for XX due to disordered meiosis as well or instead? Pretty common in hybrids.

In Evolution, a lot of stuff gets thrown at the wall and the diversity we detect is what happens to stick. 🧪

Below is the response to my question. The funny part of his response is that my research needed a control arm. My study actually did have a control arm (about 80% of the sample never reported discrimination).

So the answer itself makes me even more confused.

This week's cover @thelancet.com

The Conference of Catholic Bishops is... not playing around in this brief.

www.supremecourt.gov/DocketPDF/25...

Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate - Nature The choanoflagellate Choanoeca flexa forms motile and contractile cell monolayers purely clonally, purely aggregatively or through a combination of both processes depending on environmental condi...

Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate www.nature.com/articles/s41... #jcampubs

Just published: chemotactic sperm cells become phototactic 💡- by loading photo-activatable second messengers. This allows to "reverse-engineer" chemotactic signaling dynamics and expose cells to signals they would never see in the wild. Honoured to be part of this collaboration with the Kaupp lab.

We made FLIP2, a protein fitness benchmark spanning seven new datasets, including enzymes, protein-protein interactions, and light-sensitive proteins, as well as splits that measure generalization relevant to real-world protein engineering campaigns.

4-panel comic. (1) [Person with white hat talking to another person.] PERSON 1 with white hat: As Sherlock Holmes said, When you have eliminated the impossible, whatever remains, however improbable, must be the truth. (2) PERSON 2: What about the possibility that you forgot to eliminate a possibility? Or that you eliminated one incorrectly? Both of those remain, too. (3) PERSON 1: You’re being pedantic. It’s just a general rule for deduction. PERSON 2: But it’s a *bad rule*. (4) PERSON 2: How often have you thought, “I can’t find this thing, and I’ve searched the whole house. The only place I haven’t looked is the car, so it *must* be there.” PERSON 2: ...And then it’s never in the car. PERSON 1: *It’s never in the car!*

Eliminating the Impossible

xkcd.com/3210/

If progress is not to falter, students must be trained in open research The how and why of conducting transparent, rigorous, ethical research must be explicitly taught, say Madeleine Pownall, Charlotte Pennington and Flavio Azevedo

“Open research is about more than the tightening of analytical and methodological standards. The movement also invites us to reconsider how, and by whom, knowledge is created, shared and evaluated”

By @maddipow.bsky.social, @drcpennington.bsky.social, & @flavioazevedo.bsky.social

#MetaSci #OpenSci

a screen that says time paradox and says continue and exit Alt: Time Paradox screen that appears in the Metal Gear Solid prequels when a character dies who appeared in a game that was released earlier but set chronologically later.

dammit Snake knock that off

NIH Director Jay Bhattacharya talks 'replication crisis' at Duke panel, omits funding cuts Throughout the second Trump administration, the NIH has frozen billions of dollars in research funding to universities. Those cuts were not the topic of discussion at a Duke Clinical Research Institut...

“I want the NIH to be a central driver of the MAHA agenda,” Bhattacharya said. “Essentially, it's kind of the research arm of MAHA.”

NIH is not an ideological toy or 'arm'. We must insist on its scientific independence, especially if its Director will not.

🚨

www.dukechronicle.com/article/duke...

YouTube video by Austech 𝐓𝐚𝐥𝐤𝐢𝐧𝐠 𝐇𝐞𝐚𝐝𝐬 - 𝐋𝐢𝐟𝐞 𝐃𝐮𝐫𝐢𝐧𝐠 𝐖𝐚𝐫𝐭𝐢𝐦𝐞 - 𝐋𝐢𝐯𝐞 𝟏𝟗𝟖𝟒 - 𝟒𝐊 𝐑𝐞𝐦𝐚𝐬𝐭𝐞𝐫𝐞𝐝 #talkingheads #stopmakingsense

"Life During Wartime" (1979) - Talking Heads - Live performance "Stop Making Sense" (1984) 🎶🎧 #coffeebreak

www.youtube.com/watch?v=gn62...

This one might be even better @barrlab.bsky.social

Fascism in America will never hold.

We will win.

Minnesota just showed us how.

Luchador wearing a San Jose sharks jersey in the audience at sap center