Antoine Garnier-Crussard

Late-onset dementia with leukoencephalopathy and a COL4A2 gene variant, causal link or fortuitous association: a case report Cerebral small vessel disease can manifest as vascular dementia, typically associated with vascular risk factors or cerebral amyloid angiopathy, and m…

🚨 I share this case report, describing a case of late-onset dementia, associated with a likely pathogenic COL4A2 variant

👉 Late-onset dementia with leukoencephalopathy and a COL4A2 gene variant, causal link or fortuitous association: a case report

www.sciencedirect.com/science/arti...

🧠 🚨 New publication in Scientific Reports !

👉 Heterogeneity of white matter hyperintensities in Alzheimer’s disease captured by multimodal neuroimaging

www.nature.com/articles/s41...

👉 We studied MRI (T1w, T2w) and PET (18F-florbetapir and 18F-FDG) signals within WMH in 142 older adults

🚨Postdoc position open at @BarcelonaBeta🚨
We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠
Fully funded position!!!
More details: www.imim.cat/media/upload...
Please share!
#Alzheimer's #ENDALZ

@teddynovais.bsky.social @hcl-recherche.bsky.social

🚨 Happy to share our commentary, on Sacubitril/Valsartan, Heart Failure and Risk of Dementia 🧠💊❤️
link.springer.com/article/10.1...

The original paper link.springer.com/article/10.1...

Our review in 2024 on this topic: alzres.biomedcentral.com/articles/10....

🆘Brain & Heart health are connected 🧠❤️

Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia This Delphi study aimed to reach international consensus on the diagnosis of cognitive impairment and dementia via a revision of the International Society for Vascular Behavioural and Cognitive Disord...

🚨VasCog-2🚨

👉 Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria 🧠🩸🧠

jamanetwork.com/journals/jam...

🚨 Paper Alert

Happy to share this review on intrinsic capacity (IC) in dementia with Lewy bodies 💪🧠

🔓 www.sciencedirect.com/science/arti...

🚨 VasCog 2025 🚨 👉 The conference of the International Society of Vascular Behavioural and Cognitive Disorders

🧠 Thrilled to participate in the upcoming #VASCOG2025 conference, where I will be delivering a talk on WMH in AD

💥 program online
lnkd.in/dhhaAytZ

@hcl-recherche.bsky.social

🧠🩺Comorbidities and comorbidity burden in patients with neurocognitive disorders

👉A detailed, in-depth study of comorbidities (individual comorbidities and comorbidity indices) in >3000 real-life patients seen in memory clinics💡

@hcl-recherche.bsky.social

link.springer.com/article/10.1...

⛲💦🚰
👉"In this cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days."

Crossroads in diagnosis of dementia in England: a perilous position The recent Care England exposed further tensions in English dementia policy as regards dementia diagnosis.

My Substack. open.substack.com/pub/shibley/...

🚨 VasCog 2025 🚨 👉 The conference of the International Society of Vascular Behavioural and Cognitive Disorders

🧠 Thrilled to participate in the upcoming #VASCOG2025 conference, where I will be delivering a talk on WMH in AD

💥 program online
lnkd.in/dhhaAytZ

@hcl-recherche.bsky.social

Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis Plasma phosphorylated tau (p-tau) biomarkers show promise to transform the clinical management of Alzheimer's disease by providing more accessible and…

🧠🩸Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

www.sciencedirect.com/science/arti...

🚨 Paper Alert

Happy to share this review on intrinsic capacity (IC) in dementia with Lewy bodies 💪🧠

🔓 www.sciencedirect.com/science/arti...

What evidence do we have on the Social Determinants of Dementia (SDOD)?

Delighted that this scoping review, a year or so in the making, is now published in @alzdemjournals.bsky.social. Expertly led by Anouk Geraets, we identified...

doi.org/10.1002/alz....

1/

A randomized trial (N>2,100 participants, multi-center) of structured vs self-guided lifestyle interventions in older adults shows the former improved cognitive function jamanetwork.com/journals/jam...

Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function This randomized clinical trial assesses the effect of structured vs self-guided multidomain lifestyle interventions on changes in global cognitive function over 2 years among older adults at risk of c...

🧠🎈Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function
The US POINTER RCT

👉The structured higher-intensity intervention had a greater benefit on global cognition than the self-guided low-intensity intervention.

jamanetwork.com/journals/jam...

Donanemab receives positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in early symptomatic Alzheimer's disease | Eli Lilly and Company The Investor Relations website contains information about Eli Lilly and Company's business for stockholders, potential investors, and financial analysts.

Donanemab receives positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in early symptomatic Alzheimer's disease

investor.lilly.com/news-release...

🚀 Étude publiée sur les facteurs associés à la prescription d'une prise en soins en orthophonie 🗣️💬 en consultation mémoire 🧠 à partir des données de 574 patient-es !
www.jle.com/fr/revues/gp...

📢 Preprint alert!
Check out the results of our international consensus effort which established research recommendations and identified high-priority future directions in the field of sleep, aging and dementia. Huge thank you to ISTAART and all collaborators for this tremendous team work ✨👇

Very happy to share our preprint on the associations between sleep disturbances and cholinergic PET imaging in older adults! 🧠 💤

👉 We found that higher REM sleep EEG slowing was associated with cholinergic denervation in older participants with and without MCI.

#REMsleep #cholinergicsystem

#rfmasa2025 #lausanne #alzheimer #diagnostic #avancées #démences… | Leenaards Memory Center | CHUV 🚀 Annonce Spéciale ! 𝗥𝗙𝗠𝗔𝗦𝗔𝟮𝟬𝟮𝟱 𝗘𝗽𝗶𝘀𝗼𝗱𝗲 𝟭 Nous sommes ravis de vous annoncer que Nicolas Villain sera l'un des orateurs vedettes du congrès #RFMASA2025 à #Lausanne ! 🗣️ Il traitera du grand déb...

www.linkedin.com/posts/centre...

#rfmasa2025 #lausanne #interventions #non #médicamenteuses #prévention… | Leenaards Memory Center | CHUV 🚀 Annonce Spéciale ! 𝗥𝗙𝗠𝗔𝗦𝗔𝟮𝟬𝟮𝟱 𝗘𝗽𝗶𝘀𝗼𝗱𝗲 𝟮 Nous sommes heureux de vous annoncer que Laura Stankeviciute, PhD nous fera l’honneur de sa venue et sera l'une des oratrices renommées du congrès #RFMAS...

www.linkedin.com/posts/centre...

Common neuropathologic change drivers of hippocampal sclerosis of ageing Woodworth et al. investigate associations between common neuropathologic changes (NCs) and hippocampal sclerosis of aging (HS-A). While limbic-predominant

LATE-NC and cerebrovascular disease associated with hippocampal sclerosis, not AD pathology (in models ajdusted for LATE)

👉Common neuropathologic change drivers of hippocampal sclerosis of ageing
shorturl.at/Coxcb

Research Participant Interest in Results of Biomarker Tests for Alzheimer Disease This cohort study quantitatively and qualitatively assesses research participants’ decision to learn individual Alzheimer disease biomarker research results and what factors are associated with this d...

Research Participant Interest in Learning Results of Biomarker Tests for AD

👉in this cohort study of 274 individuals with available biomarker data, 40% of participants declined the option to learn their AD research results

shorturl.at/9Rbgv

🧠Exciting new findings from a great collaboration between the BioFINDER study and the talented
@xiaoyucaly.bsky.social from @jwvogel.bsky.social group!! In their preprint, they show that tau presence and tau load are guided by unique brain mechanisms. Dive into the details here 👇

Neurodegeneration and the immune system: lessons from autoimmune encephalitis - Journal of Neurology The spectrum of autoimmune encephalitis (AE) is expanding to atypical clinical presentations that can mimic neurodegenerative disorders. Among the autoantibodies most frequently associated with manife...

Neurodegeneration and the immune system: lessons from autoimmune encephalitis
link.springer.com/article/10.1...

Brain health services for the secondary prevention of cognitive impairment and dementia: Opportunities, challenges, and the business case for existing and future facilities

doi.org/10.1016/j.tj...

Assessment and management of frailty in individuals living with dementia: expert recommendations for clinical practice Frailty complicates the care of individuals with dementia, increasing their vulnerability to adverse outcomes. This Personal View presents expert recommendations for managing frailty in individuals wi...

🧠💪🏿Assessment and management of frailty in individuals living with dementia: expert recommendations for clinical practice

www.thelancet.com/journals/lan...

🚨 Great news for our GP colleagues and for the entire scientific and medical community !
👇