Lily Keane

Incredibly honoured to receive prestigious
@researchireland.ie funding to study developmental vulnerabilities in diffuse midline glioma (DIPG/DMG).

Huge thanks to my amazing mentor @jfcryan.bsky.social
Excited for what’s ahead!

@apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social

A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...

Thrilled to see our review out in @natrevimmunol.nature.com together with my amazing mentors @jfcryan.bsky.social and Ger Clarke. @apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social @uccresearch.bsky.social

www.nature.com/articles/s41...

A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...

A Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social @apcmicrobiomeirel.bsky.social proposes that microbiota–microglia cross-talk may have major implications for our understanding of neurological disorders and neuropsychiatric disease
#immunosky #microsky #microbiome

The Keane lab is hiring! Join our team at
@apcmicrobiomeirel.bsky.social
on an exciting new project trying to understand how the gut-brain axis shapes the tumour microenvironment of Diffuse Midline Glioma #cryanlab #DMG #DIPG

Apply here using using Job Id 085551
ucc.ie/en/hr/vacanc...

@cancerresearch-ucc.bsky.social, @apcmicrobiomeirel.bsky.social

Delighted to see our recent perspective in Trends in Molecular Medicine, part of @cellpress.bsky.social making the cover! In this perspective, we discuss the potential to exploit the gut microbiome to improve responses to current and novel brain tumour treatments. @jfcryan.bsky.social, Jack Gleeson

Latest lab review-
The Gut microbiota-Immune-Brain axis: Therapeutic Implications. Just out in @cp-cellrepmed.bsky.social Well done @kjdoriordan.bsky.social @moloneyger.bsky.social & @lilykeane.bsky.social www.cell.com/cell-reports...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

🎉 Huge congratulations to @roisinmcmanus.bsky.social and Michael Heneka on this exciting study uncovering a novel role for NLRP3 in regulating microglial metabolism and phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/abs...

Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions Cell Death Discovery - Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions

Happy to be part of this new and exciting study from @bertrandjoseph.bsky.social lab @karolinskainst.bsky.social where we identify critical molecular determinants of microglial cellular aging, including SLC16A3 and P2RY13 www.nature.com/articles/s41...?

CAR T Cell Therapy Offers Hope Against DIPG – Featured Research Encouraging success from Seattle Children’s cancer doctor and researcher Nick Vitanza dosing CAR T cell therapy directly to brain for patients with DIPG.

Gavin's story lifts my heart. What an inspiration!

www.seattlechildrens.org/research/fea...

So proud of @larswilmes.bsky.social or should I say Dr. Wilmes for successfully defending his PhD yesterday.

Me too thanks

amazing Jatin! Thank you!

Could you add me please

Please add me thanks Giorgio