ImmunoSketch

A starter pack for PhD students and Postdocs in Immunology to connect 🔽

Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!

#ImmunoSky 🧪

go.bsky.app/RABVXY4

#Preprints start the conversation, and #PeerReview pushes research forward. That’s how every discovery we illustrate here takes shape.

Our friends over at The Modern Peer are breaking it all down—check out their blog!
www.themodernpeer.com

#AcademicSky #PhDSky #SciPub #SciComm #AcademicChatter 🧪

This concludes our 10-day journey and the ImmunoSketch adventure. Thank you for joining in.
May your new year be as resilient and adaptive as the cells we study.
Happy new year! 🎄

Hidden among our immune system's seeds, scientists found special ones that could revolutionize cancer treatments and vaccines.

@deekshadeep @danapeer.bsky.social @jexpmed.bsky.social

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#ImmunoSky 🧪

And for the grand finale: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity. A perfect reminder of immunology’s complexity—how one decision can shape an entire fate.

Imagine tiny engineers in your skin fine-tuning your nerves to detect allergens more easily.

@theILCguy @sokol_mdphd @forum-gd.bsky.social @nature.com

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#ImmunoSky 🧪

Day -2 highlights an immune-sensory dialogue: A γδ T cell–IL-3 axis controls allergic responses through sensory neurons. Immunology doesn’t just fight disease—it listens, connects, and responds. A beautiful symphony of cells to close out the year.

Imagine your immune system as a symphony, where testosterone conducts uniquely tuned performances.

@petterbrodin.bsky.social @karolinskainst.bsky.social @nature.com

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#ImmunoSky 🧪

On day -3, we spotlight adaptation: Immune system adaptation during gender-affirming testosterone treatment. A testament to the immune system’s flexibility and resilience—much like the spirit we carry into the new year.

Even at the very start, some cells in the embryo already have different jobs.

@LIwamotoStohl @zernickagoetz.bsky.social @slavovlab.bsky.social

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#ImmunoSky 🧪

Day -4 turns our focus to early development: Proteome asymmetry in mouse and human embryos before fate specification. A fascinating reminder that immune-related pathways often begin shaping outcomes before fate is even sealed.

Imagine the uterine lining as a garden, where special cells act as dedicated gardeners, keeping it healthy and vibrant.

@vikilovesfacs.bsky.social

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#ImmunoSky 🧪

On day -5, we celebrate immune cells in regeneration: Dynamic roles of ILC3 in endometrial repair and regeneration. Just like the new year brings fresh beginnings, ILC3s show us how the immune system fosters repair and renewal.

Septins act like tiny security guards in our cells, triggering a self-destruct mode to fight off harmful bacteria.

@MostowyLab @DBrokatzky
@lshtm.bsky.social @cp-cellchembiol.bsky.social

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#ImmunoSky 🧪

Day -6 dives into the mechanics of cell death: Septins promote macrophage pyroptosis. Who knew cell death pathways could bring such dramatic energy to the immunology stage?

Breast cancer cells can be kept in check in the lungs by immune cell guardians that send a "sleep signal".

@eriDalla @micpapanicolaou.bsky.social
@JAguirreGhiso @casanova-acebes.bsky.social @miriammerad.bsky.social @dentenberg.bsky.social

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#ImmunoSky 🧪

Day -7 brings us a lesson in perfect timing: Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis. A reminder that, like the holiday season, the immune system knows when to act—and when to wait.

Bacteria outsmart phages with a clever card trick, going dormant to dodge attacks.

@drdorsalomon.bsky.social
@naturemicrobiol.bsky.social

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#ImmunoSky 🧪

Day -8 shines a light on nature’s microscopic defense systems: Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools. Like an immune system stocking stuffer, these mobile elements carry all the surprises—tools for attack and defense.

On day -9 of our year-end countdown, we celebrate immune engineering at its finest: A tetraspecific engager armed with a non-alpha IL-2 variant harnesses NK cells against B cell NHL. Natural killer cells armed and ready—it’s immunology’s version of Santa’s sleigh delivering precision medicine.

In newborns, tiny traffic cops in the liver need a GPS to find their way to the bloodstream and protect against infections.

@brunaraujodavid @Kubes_Lab
@immunoeditor.bsky.social
@sciimmunology.bsky.social

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#ImmunoSky 🧪

Day -10: Today’s highlight takes us to the liver: Kupffer cell reverse migration into liver sinusoids mitigates neonatal sepsis and meningitis. Proof that even immune cells can come home for the holidays—and do remarkable things when they get there.

Thank you for reading, sharing, and engaging. Immunology will march on, and so will we—toward more discoveries, more papers, and hopefully, more ways to make sense of it all. Happy holidays and here’s to a new year full of resilience, balance, and maybe a few less cytokines.

Maybe it clarified a concept, sparked curiosity, or at least made someone say, “Huh, that’s actually pretty cool.” Because it is.

To wrap it all up with a proper farewell, I’ll revisit 10 of the best posts over the next 10 days—one each day as we count down to the year’s end.

it’s the pursuit of answers to systems more complex than any holiday dinner debate you’ll face this season.
It’s bittersweet to close this chapter, but I’m proud to have put this work out into the world.

Immunology is hard to explain, and harder still to simplify without losing its elegance. But I hope these posts shed light on why we obsess over the beautiful chaos of immune regulation. Science isn’t just papers and data—

After six months, the ImmunoSketch project has officially reached its end. The goal? To take our intricate, jargon-heavy science and turn it into something your loved ones might finally understand—so they stop assuming you just “look at cells” all day.

CAR-T cells aim to hit cancer targets, but when the target’s unclear, treatment struggles to succeed.

@freemanlciaraMD @DrFredLocke @bloodjournal.bsky.social

t.co/bPTq2SJzx8
#ImmunoSky 🧪

Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose.

@mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com

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#ImmunoSky 🧪

Some immune cells fuel the fire of disease, while others help put it out—finding the balance could change treatments.

@juliosds1.bsky.social

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#ImmunoSky 🧪