@shaharsu.bsky.social
Alternating between running a lab at UC Merced and taking care of the kids. Tweets mostly science related.
Promotional image of a plant growing in the desert for the First Annual WALII Symposium: Exploring Life Without Water. The graphic includes the date and time of the event and information on how to register.
The First Annual Virtual WALII Symposium: Exploring Life Without Water is ONE WEEK AWAY! ποΈπ§
Register now to join us on November, 18!
www.walii.science/virtual-symp...
π¨π¨The GRC on Intrinsically Disordered Proteins #IDPs is back!! ππ§΅ποΈJoin us for cutting-edge IDP science, great discussions, and mountain views ππ
π
June 21-26, 2026 | Les Diablerets, Switzerland
π Details & registration: grc.org/intrinsicall...
π¨The 2026 IDP GRC Program is LIVE! π£
Check it out: www.grc.org/intrinsicall...
Weβve got an incredible speaker lineup! π
Over the next few weeks, weβll be highlighting some of them and giving you a sneak peek at the exciting topics theyβll be covering. Stay tuned!
πExcited to announce that Dr. Rebecca Berlow @berlowlab.bsky.social
will speak in the βDisorder in Pathogensβ session at #IDPGRC2026!
The Berlow lab uses solution NMR and biophysical approaches to uncover how IDP sequence, dynamics & function drive transcriptional regulation.
π₯οΈNext up: Jeetain Mittal in the Material Properties of IDPs and Condensates session! His team uses multiscale simulations to uncover how sequence-encoded interactions in IDPs govern conformational transitions & condensate behavior - informing neurodegenerative research. @mittalgrouptamu.bsky.social
28.10.2025 10:24 β π 2 π 1 π¬ 0 π 0π’ Abstract deadline Nov 1!
Join us at the FASEB Conference on Biomolecular Phase Transitions (Jan 11β15, 2026, Melbourne, FL), showcasing cutting-edge research on condensates in health & disease, and therapeutic frontiers.
~30% talks from abstracts!
events.faseb.org/event/480194...
Thanks @elevylab.bsky.social for a fantastic writeup!!
16.10.2025 09:48 β π 3 π 0 π¬ 0 π 0Can't wait to see you all there!!
03.10.2025 13:40 β π 4 π 1 π¬ 0 π 0The power of collaborations! With @shaharsu.bsky.social, his PD @jessniblo.bsky.social and CALVADOS3 (thanks to @lindorfflarsen.bsky.social ) we show how STI1 (red) may engage with sequences that match transient helices within IDRs of Ub-binding shuttle protein Dsk2 www.biorxiv.org/content/10.1...
23.05.2025 13:18 β π 10 π 3 π¬ 0 π 0
Announcing the joint @idpseminars.bsky.social / BPS IDP Subgroup Trainee Symposium Speakers!
Join us on Mar 27, 12β2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!
π’ Excited to share our research with @shaharsu.bsky.social & @mvstaller.bsky.social on how activation domain (AD) structure affects gene expression! 𧬠TLDR: HIF-1Ξ± & CITED2 ADs suggest ensemble dimensions may regulate transcription in unique ways.
www.cell.com/biophysrepor...
𧡠Highlights:
Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models).
www.biorxiv.org/content/10.1...
The STARLING has landed - excited to share new work from @bornanovak.bsky.social and @jefflotthammer.bsky.social in what is also Borna's first Bluesky post!
If you're at BPS, I'll be speaking about this this afternoon in IDP SG, and Borna and Jeff both have posters (Sunday B112 and Wed B152).
Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social
07.02.2025 18:31 β π 8 π 9 π¬ 1 π 1
Great work from Eduardo Flores and our new neighbors Nirbhik and Carlos from @castanedalab.bsky.social. In case you're interested in more info, check out the full analysis here: github.com/sukeniklab/C...
07.02.2025 19:55 β π 1 π 0 π¬ 0 π 0
ππ§ͺNew perspective paper! Single-point missense mutations are common in disordered regions but are often overlookedπ. We analyzed thousands of IDR point mutations associated with human congenital diseases to show that many can significantly change local IDR ensemble structure!
shorturl.at/iIbLX
Poster for Adam Klosin and Randal Halfmann's IDPSeminars talks. Adam's (from the Nencki Institute of Experimental Biology of the Polish Academy of Sciences) talk is titled "Organization of stress response in the nuclei of developing C. elegans embryos", while Randal's (from the Stowers Insitute) talk is titled "Sequence-structure relationships of amyloid kinetics in cells".
We're back for 2025! This week we welcome Adam Klosin and Randal Halfmann for the first IDPSeminar of Season 17!
07.01.2025 17:22 β π 24 π 12 π¬ 0 π 0
New collaborative work in collaboration with the labs of Robert Best & Tanja Mittag driven by Ben Schuler.
Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations.
pubs.acs.org/doi/10.1021/...
Last chance to submit your abstract (deadline Tuesday, Feb 20!) for posters & talks for the upcoming EMBO/EMBL Symposium "Cellular mechanisms driven by phase separation", taking place May 14-17 2024 in Heidelberg
www.embl.org/about/info/c...
πFinally out! Our paper shows that intramolecular interactions in disordered proteins π can be strong enough to hold inside the cell. 2 years in the making and a labor of love of many people, including @alexholehouse.bsky.social. rdcu.be/du9TY
04.01.2024 14:39 β π 7 π 3 π¬ 0 π 0
Today presenting alongside Benedetta Bolognesi in the Condensate Colloquium Series. Not on Bluesky yet, so must shamelessly self-promote, see yours later :-)
Also, repost appreciated π
A labor of love - our review on why IDRs matter for cellular function is live in Nat. Rev. Mol. Cell. Biol:
www.nature.com/articles/s41...
Working with Birthe Kraglund on this was such a pleasure, and we hope this review will be helpful to a broad audience!
