Shahar Sukenik

The power of collaborations! With @shaharsu.bsky.social, his PD @jessniblo.bsky.social and CALVADOS3 (thanks to @lindorfflarsen.bsky.social ) we show how STI1 (red) may engage with sequences that match transient helices within IDRs of Ub-binding shuttle protein Dsk2 www.biorxiv.org/content/10.1...

Announcing the joint @idpseminars.bsky.social / BPS IDP Subgroup Trainee Symposium Speakers!

Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!

📢 Excited to share our research with @shaharsu.bsky.social & @mvstaller.bsky.social on how activation domain (AD) structure affects gene expression! 🧬 TLDR: HIF-1α & CITED2 ADs suggest ensemble dimensions may regulate transcription in unique ways.
www.cell.com/biophysrepor...
🧵 Highlights:

Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models).
www.biorxiv.org/content/10.1...

The STARLING has landed - excited to share new work from @bornanovak.bsky.social and @jefflotthammer.bsky.social in what is also Borna's first Bluesky post!

If you're at BPS, I'll be speaking about this this afternoon in IDP SG, and Borna and Jeff both have posters (Sunday B112 and Wed B152).

Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social

ClinVar_Re_predictions/analysis/plotClinvarAll.ipynb at main · sukeniklab/ClinVar_Re_predictions A companion repo for Flores et al., Current Opinion in Structural Biology 2025 - sukeniklab/ClinVar_Re_predictions

Great work from Eduardo Flores and our new neighbors Nirbhik and Carlos from @castanedalab.bsky.social. In case you're interested in more info, check out the full analysis here: github.com/sukeniklab/C...

🎉🧪New perspective paper! Single-point missense mutations are common in disordered regions but are often overlooked👀. We analyzed thousands of IDR point mutations associated with human congenital diseases to show that many can significantly change local IDR ensemble structure!

shorturl.at/iIbLX

Poster for Adam Klosin and Randal Halfmann's IDPSeminars talks. Adam's (from the Nencki Institute of Experimental Biology of the Polish Academy of Sciences) talk is titled "Organization of stress response in the nuclei of developing C. elegans embryos", while Randal's (from the Stowers Insitute) talk is titled "Sequence-structure relationships of amyloid kinetics in cells".

We're back for 2025! This week we welcome Adam Klosin and Randal Halfmann for the first IDPSeminar of Season 17!

Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations It has become increasingly evident that the conformational distributions of intrinsically disordered proteins or regions are strongly dependent on their amino acid compositions and sequence. To facili...

New collaborative work in collaboration with the labs of Robert Best & Tanja Mittag driven by Ben Schuler.
Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations.
pubs.acs.org/doi/10.1021/...

Cellular mechanisms driven by phase separation

Last chance to submit your abstract (deadline Tuesday, Feb 20!) for posters & talks for the upcoming EMBO/EMBL Symposium "Cellular mechanisms driven by phase separation", taking place May 14-17 2024 in Heidelberg
www.embl.org/about/info/c...

🎉Finally out! Our paper shows that intramolecular interactions in disordered proteins 🍝 can be strong enough to hold inside the cell. 2 years in the making and a labor of love of many people, including @alexholehouse.bsky.social. rdcu.be/du9TY

Today presenting alongside Benedetta Bolognesi in the Condensate Colloquium Series. Not on Bluesky yet, so must shamelessly self-promote, see yours later :-)

Also, repost appreciated 🙏

A labor of love - our review on why IDRs matter for cellular function is live in Nat. Rev. Mol. Cell. Biol:
www.nature.com/articles/s41...

Working with Birthe Kraglund on this was such a pleasure, and we hope this review will be helpful to a broad audience!