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5th Anniversary Thematic Collection: Manipulating DNA Repair and the DNA Damage Response to Improve Cancer Therapy url:https://academic.oup.com/narcancer/pages/manipulating-dna-repair @emgsus.bsky.social @weldeiry.bsky.social

US Congress set to reject Trump’s sweeping science budget cuts Lawmakers announce legislation that would actually increase funding for basic research by more than 2%.

US Congress set to reject Trump’s sweeping science budget cuts www.nature.com/articles/d41...

Fantastic review from my former colleague Ming Tan: Exploiting metabolic vulnerabilities to improve cancer therapeutics: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...

Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis Abstract. Poly(ADP-ribose) polymerases 1 and 2 (PARP1/PARP2), and poly(ADP-ribose) glycohydrolase (PARG), modulate the level of poly(ADP-ribose) (PAR), a p

Great to see our latest study out in NAR Cancer: Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis url: academic.oup.com/narcancer/ar... @weldeiry.bsky.social @emgsus.bsky.social

Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis Abstract. Poly(ADP-ribose) polymerases 1 and 2 (PARP1/PARP2), and poly(ADP-ribose) glycohydrolase (PARG), modulate the level of poly(ADP-ribose) (PAR), a p

Great to see our latest study out in NAR Cancer: Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis url: academic.oup.com/narcancer/ar... @weldeiry.bsky.social @emgsus.bsky.social

#ThisIsTrumpsShutdown 🚫

Fantastic review from my former colleague Ming Tan: Exploiting metabolic vulnerabilities to improve cancer therapeutics: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...

Great opportunity at NAR @emgsus.bsky.social @ianywonglab.bsky.social @weldeiry.bsky.social

Olympics organizers willing to treat Trump like a toddler to protect 2028 LA Games | Opinion President Donald Trump is leading an Olympics task force to handle security issues that are already being handled for the 2028 Games in Los Angeles.

Check out this article from USA TODAY:

Olympics organizers willing to treat Trump like a toddler to protect 2028 LA Games | Opinion

www.usatoday.com/story/sports...

Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...

RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. A proteomics approach is developed using these domains to map ADP-ribosyl-ubiquitylation sites

www.nature.com/articles/s41...

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...

www.science.org/doi/10.1126/...

Blue and green background with white text that reads "GP2 Data Update, Release #10" and a small icon below the text.

🔔 GP2’s 10th data release is live on the cohort dashboard!

It includes a new family file and data discovery report with pairwise kinship estimates, capturing both inferred and reported relationships.

🧪 Learn more: gp2.org/the-components-of-gp2s-10th-data-release/

2025 Samuel H. Wilson Award for Studies on DNA Repair Winner - Environmental Mutagenesis and Genomics Society Mark Hedglin, PhD Assistant Professor of Chemistry, The Pennsylvania State UniversityPenn State Huck Institute of the Life Sciences, Center for Structural Biology  Penn State Huck Institute of the Life Sciences, Molecular, Cellular, and Integrative Biosciences (MCIBS)

Congratulations to Mark Hedglin, PhD: the 2025 Samuel H. Wilson Award for Studies on DNA Repair Winner @emgsus.bsky.social emgs-us.org/news/news.as...

TRIP12’s role in the governance of DNA polymerase β involvement in DNA damage response and repair Abstract. The multitude of DNA lesion types, and the nuclear dynamic context in which they occur, presents a challenge for genome integrity maintenance as

Thrilled to share how proteomic analysis led to the discovery of "TRIP12’s role in the governance of DNA polymerase β involvement in DNA damage response and repair" url: academic.oup.com/nar/article/... @ianywonglab.bsky.social @weldeiry.bsky.social @emgsus.bsky.social

👇we must resist

Judge rules some NIH grant cuts illegal, saying he's never seen such discrimination in 40 years A federal judge says it was illegal for the Trump administration to cancel several hundred research grants issued by the National Institutes of Health.

Judge rules some NIH grant cuts illegal, saying he's never seen such discrimination in 40 years

apnews.com/article/nih-...

NIH scientists publish declaration criticizing Trump's deep cuts in public health research Scores of National Institutes of Health researchers and staffers have come forward to send their Trump-appointed leader a letter challenging policies they say undermine the NIH mission.

NIH scientists publish declaration criticizing Trump's deep cuts in public health research

apnews.com/article/nih-...

DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint Head and Neck Squamous Cell Carcinoma (HNSCC) imposes a significant health burden, necessitating innovative therapeutic strategies to enhance treatmen…

Check out our latest: DNA polymerase beta expression in head and neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint: www.sciencedirect.com/science/arti... @weldeiry.bsky.social @emgsus.bsky.social

All of us are in grave danger this year before of this inept fascist takeover

Remember folks, the budget cuts for NSF and NIH *can still be stopped*. That is a luxury not granted to our agency science colleagues who have or could still lose their jobs from the top down. So - Fight! Speak up! Pay attention!

Science in War, Science in Peace: The Origins of the NSF - JSTOR Daily The 1950 establishment of a federal agency devoted to space, physics, and more belied a cross-party consensus that such disciplines were vital to national interest.

Science in War, Science in Peace: The Origins of the NSF daily.jstor.org/science-in-w...

Trump Has Cut Science Funding to Its Lowest Level in Decades (Gift Article) The lag in funding extends far beyond D.E.I. initiatives, affecting almost every area of science: chemistry, computing, engineering, materials and more.

NSF Physics was cut by 85%, basically wiping out most of its capacity for supporting research.

NSF Astronomy was cut by 53%

Undergrad education was cut by 71% and research on learning by 79%

Graduate education was cut by 100% to ZERO.

#GiftLink ⚛️🔭

www.nytimes.com/interactive/...

Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage Protein poly-ADP-ribosylation (PARylation) is a post-translational modification formed by transferring successive units of ADP-ribose to target protei…

Interested in proteins that bind to poly(ADP-ribose)? Check out our recent study here at the Legorreta Cancer Center at Brown University on WWE domains and binding to poly(ADP-ribose) in cells: www.sciencedirect.com/science/arti... @brownuresearch.bsky.social @weldeiry.bsky.social

Renewal of NIH grants linked to more innovative results, study finds Survey of hundreds of scientists’ work suggests that cutting off funding disrupts focus and reduces the novelty of research.

Innovation takes time

US scientists who received renewals from the NIH over the past four decades produced more novel research than those who didn’t
https://go.nature.com/44oKEwV

A US judge to govt lawyers defending the NIH's grant terminations:

"I understand the administration is against DEI. Respectfully, I just don't know what you mean. This isn't a teasing question. There has to be some working definition.

This is research to advance healthcare for all our citizens."

Due to great enthusiasm, we are extending the early bird registration deadline, at a reduced rate, until 25 May. After this date, the rate will increase by 1500NOK (approx. 135USD). We look forward to seeing you in Trondheim! www.endodnadamage.com

‘50501’ protesters denounce Trump administration in nationwide rallies while supporting to impacted communities | CNN A national day of action against President Donald Trump and his administration has united an outpouring of protesters across the country who are rallying in defiance of what they describe as a relentl...

www.cnn.com/2025/04/19/u...

Opinion | A Playbook for Standing Up to President Trump Law firms and universities do not need to capitulate. Here’s how they can fight back.

www.nytimes.com/2025/04/06/o...

Sam Wilson Award Application Form - Environmental Mutagenesis and Genomics Society 11/28/2023July 2023 EMM Editor's Choice Article

Apply Now for the 2025 Samuel H. Wilson Award for Studies on DNA Repair - emgs-us.org/general/cust... @emgsus.bsky.social @weldeiry.bsky.social @ianywonglab.bsky.social

Legorreta Cancer Center Newsletter | Spring 2025 createsend.com/t/r-01DBD817...