Lucina Uddin

Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression Abstract. Ketamine produces fast-acting antidepressant effects in treatment resistant depression (TRD). Prior studies have shown altered functional dynamics between brain networks in major depression. We thus sought to determine whether functional brain network dynamics are modulated by ketamine therapy in TRD. Participants with TRD (n=58, mean age=40.7 years, female=48.3%) completed resting-state fMRI scans and clinical assessments (mood and rumination) at baseline and 24 h after receiving four ketamine infusions (0.5mg/kg) over two weeks. Healthy controls (HC) (n=56, mean age=32.8 years, female=57.1%) received the same assessments at baseline and after two weeks in a subsample without treatment. A co-activation pattern (CAP) analysis identified recurring patterns of brain activity across all subjects using k-means clustering. Statistical analyses compared CAP metrics including the fraction of time (FT) spent in a brain state, and the transition probability (TP) from one state to another over time and associations with clinical improvement. Follow-up analyses compared HC and TRD at baseline. Six brain state clusters were identified, including patterns resembling the salience (SN), central executive (CEN), visual (VN), default mode (DMN), and somatomotor (SMN) networks. Following ketamine, TRD patients showed decreased FT for the VN (p=7.4E-04) and increased FT for the CEN state (p=1.9E-03). For TP metrics, SN-CEN increased (p=5.8E-04) and SN-VN decreased (p=3.6E-03). Decreased FT for the SN associated with improved rumination (p=1.9E-03). At baseline, lower FT for CEN (p=5.70E-04) and TP for SN-CEN (p=0.016) and higher TP for SN-VN (p=2.60E-03) distinguished TRD from HCs. CAP metrics remained stable over time in a subsample of HCs (n=18). These findings suggest ketamine modulates brain network dynamics between SN, CEN and VN in TRD, which may normalize dynamic patterns seen in TRD at baseline towards patterns seen in controls. Changes in SN state dynamics may correspond to improvements in ruminative symptoms following ketamine therapy.

New from Brandon Taraku 🧠: Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression url: direct.mit.edu/imag/article...

We're a month further into the job market - how are things looking? The good news is that the market does seem to have been delayed: ~150 new listings have appeared since my last post. The bad news is that the total is still substantially lower than what it was during the covid dip.

@theabcdstudy.bsky.social

Want to learn more about the Adolescent Brain Cognitive Development study?👀 Check out the ABCD-ReproNim course! The Fall 2025 course is going on NOW✨ Students may have the opportunity to participate in the 2026 hackathon in Miami🏝️ For more info: abcd-repronim.org 🎉

Thanks for the figure @bttyeo.bsky.social 🙂🧠🙏🏽!

NIH awarded 37 percent fewer neuroscience-related grants in 2025 than in past years But the agency has spent nearly its entire budget for this fiscal year, which ends tomorrow.

www.thetransmitter.org/funding/nih-...

Figure from paper showing "The Brain is ..." at the top and answers in a 2D embedding space at the bottom.

Complete this sentence, "The brain is ...".
What's your favorite answer? I'm team cluster 17/18.

Taken from this delightful paper by Taylor Bolt and @lucinauddin.bsky.social; results of text in >4 million peer-reviewed articles + text analytic tools.

pubmed.ncbi.nlm.nih.gov/39798046/

Federal judge orders Trump to restore $500 million in frozen UCLA medical research grants A San Francisco-based federal judge on Monday ordered the Trump administration to restore all National Institutes of Health grants to UCLA, roughly $500 million, that the government suspended in July.

BREAKING: A federal judge has ordered Trump to restore $500 million in frozen UCLA NIH grants. The same judge, Rita F. Lin, previously ordered all UCLA NSF grants reinstated. Lin has now nearly entirely reversed Trump's July de-funding of UCLA research: www.latimes.com/california/s...

Check out the new release from @themindwanders.bsky.social 🧠🌎 @ohbmofficial.bsky.social @ohbmtrainees.bsky.social @ohbmenvironment.bsky.social

UC employees, not waiting on leaders, sue Trump for 'financial coercion' over UCLA cuts University of California faculty, students and staff on Tuesday sued President Trump over a $1.2-million penalty against UCLA and federal demands over campus changes. They argued that the actions camp...

Facing a proposed $1.2-billion fine and severe medical research grant cuts at UCLA, the University of California has not gone head-to-head with Trump in court.

So on Tuesday, groups representing more than 100,000 of its employees did.

www.latimes.com/california/s...

International scientific collaboration is more necessary—yet more challenging—than ever These partnerships accelerate neuroscience by enabling researchers to share resources and expertise, as well as generate more relevant and reproducible results. But new federal funding restrictions in...

International collaborations enable the sharing of resources and expertise, as well as more broadly applicable and reproducible results. But new U.S. federal funding restrictions are putting them in jeopardy, writes @lucinauddin.bsky.social.

#neuroskyence

www.thetransmitter.org/funding/inte...

That’s a wrap! Thanks for a great #Flux2025 meeting, Dublin 🧠 @fluxsociety.bsky.social

The APC at @imagingneurosci.bsky.social is now only $1400! Keep the great submissions coming 🧠 @ohbmofficial.bsky.social @ohbmtrainees.bsky.social

See you in Noosa! 🧠

Amazing first day at #Flux2025 featuring an all-star team discussing the last 10 years (and future 10 years!) of ABCD & an inspiring conversation about bridging the lab and real life 🧠🤩

@lucinauddin.bsky.social @dbarch.bsky.social @tervoclemmensb.bsky.social @fluxsociety.bsky.social

Go on the job market early and often

This one is for @bttyeo.bsky.social 🙂

All @imagingneurosci.bsky.social papers are now on PubMed! 🧠

Trump administration must restore hundreds of UCLA research grants, federal judge rules A federal judge on Tuesday ordered Trump administration to restore hundreds of frozen National Science Foundation research grants to UCLA.

BREAKING: A San Francisco-based judge has ordered the Trump administration to restore hundreds of science research grants to UCLA, more than a third of the $584 million in funds the government has cut: www.latimes.com/california/s...

‘A whole body of health-equity research is being disappeared’ — why I resigned from the NIH As federal support vanishes for research addressing the root causes of health disparities in the United States, we are left with a dangerous void and an urgent need to rethink science funding.

As federal support vanishes for research addressing the root causes of health disparities in the United States, we are left with a dangerous void and an urgent need to rethink science funding, says Vani Pariyadath

go.nature.com/4mlvEGo

Stand Up for UC We must stand together to protect our students, staff, faculty and our mission.

Let’s do this www.universityofcalifornia.edu/get-involved...

The bear has been poked

JOB ALERT: Computational Cognitive Neuroscience Postdoc position in Osaka, Japan! Possible start in October 2025 (contact me ASAP), or from April 2026. PLEASE REPOST! #postdocjobs #neuroskyence #neuroscience #psychscisky #compneurosky #neurojobs 1/

Request for Information on Maximizing Research Funds by Limiting Allowable Publishing Costs
grants.nih.gov/grants/guide...

NSF and NIH suspend grants to UCLA | Science | AAAS www.science.org/content/arti...

We back on this again

Looking for @theabcdstudy.bsky.social fMRI timeseries data?It's all in the 6.0 data release, thanks to @drdamienfair.bsky.social and team at ABCC 🧠: docs.abcdstudy.org/latest/docum...

Am I the only one who doesn’t do lab meetings over the summer?!

fMRI Course Instructors

Online #fMRI course coming up August 6-8!
3-day intensive with lectures and hands-on analysis for all skill levels. #SPM, #ICA, #DataScience with @vcalhoun.bsky.social and Kent Kiehl. We love teaching this course and meeting students from all areas! Info+Reg here:
sites.google.com/dartmouth.ed...

Ireland launches global talent fund! www.researchireland.ie/funding/glob...
If you're a neuroscience professor (assistant/associate/full) and would consider relocating to the vibrant and booming city of Dublin, please get in touch!