Brian Plosky

Custom lab bench Lego set with Arc Institute logo

And, if you’re lucky enough to already have custom lego sets with your institutes logo, you could probably swap them right in! @arcinstitute.org

This is very cool. I’m a bit worried about the use of “cookie elements” for what might be petri dishes. Maybe a lab safety problem?!?!?🙃

Biological Laboratory | LEGO® Ideas This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...

Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease A nutrigenomics framework identifies genetic diseases amenable to vitamin B2 and B3 therapies. This approach nominates vitamin B3 as a therapy for NAXD deficiency, a lethal neurodevelopmental disorder...

🚨 🚨 NEW PUBLICATION 🚨 🚨 "Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease"

@arcinstitute.org
@ishahjain.bsky.social
@cp-cell.bsky.social

Most drug discovery starts with a disease & searches for a cure. New research out in Cell from Arc investigator Isha Jain’s lab flips this model, starting with a potential cure (vitamins) & systematically identifying which diseases it could treat.

Arc AIxBio Fellows Program for Undergrads | Arc Institute Arc Institute is a independent nonprofit research organization headquartered in Palo Alto, California.

A reminder that applications close Friday, Feb 27 for the Arc AIxBio Fellows Program.

Undergrads: propose and run your own AI + biology research project over 6–12 months, with mentorship from Arc scientists. Apply solo or as a team of 2–3.

arcinstitute.org/programs/aix...

People living at high altitude have better glucose tolerance & lower diabetes risk, but the mechanism behind why has remained a mystery. New research out in Cell Metabolism from Isha Jain's lab reveals an unexpected answer—red blood cells.

Most genetic interaction studies measure gene relationships in one condition, but environment can reshape which genes depend on each other.

Today in Molecular Cell, Luke Gilbert & team deliver the first systematic, multi-condition map of genetic rewiring in human cells.

Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.

Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.

Amazing collaboration with the Jain lab! The impact of systemic hypoxia on cancer!

In this Molecular Cell Voices piece, @genophoria.bsky.social comments on how he thinks about bridging bench and computational work: www.cell.com/molecular-ce...

An amazing day for science at the 2nd Annual Arc Symposium!

Thank you to everyone who joined us from our labs, technology centers, partner universities, and beyond. We are so grateful that you're part of our community.

Today I’m happy to release cyto, a tool I’ve developed at @arcinstitute.org to dramatically increase our computational throughput with 10x-flex single-cell processing by more than 16X!

A new paper from Jeffrey Wang, @genophoria.bsky.social, and team describes orphan non-coding RNAs, known as "oncRNAs," as cancer-emergent molecules with important roles in tumor identity and progression, and clinical monitoring across human cancers: www.cell.com/cell-reports...

In a new review published in @cp-neuron.bsky.social, @christophthaiss.bsky.social and team synthesize emerging research on intestinal interoception, highlighting how signals from the gut shape communication between the environment, the body, and the brain to maintain human health.

Predicting cell state in previously unseen conditions has typically required retraining for each new biological context. Today, Arc is releasing Stack, a foundation model that learns to simulate cell state under novel conditions directly at inference time, no fine-tuning required.

Today, we welcome Megan van Overbeek as our first Chief Scientific Officer.

At Arc, she'll drive the discovery of novel therapeutic strategies for complex diseases, bringing expertise that bridges fundamental research with therapeutic development.

Christmas card with a green background and a Zoom meeting screenshot with 12 members of the openRxiv team (top to bottom, left to right the name tags say: Tracy Teal, Olaya, Sam Hindle, Richard Sever, Gumdrop - Master Elf, Ted Roeder, Sol, Joanne McFadden, John Inglis, Martina, Josh Sinanan, Sanchari Ghosh). The text says "Happy Holidays from the openRxiv team."

The @openRxiv.bsky.social team wishes all of our authors, readers, Affiliates and community members a very happy holiday season and turn of the year!
Please excuse any delays in processing your submissions while our staff also enjoy some well-deserved time off ☃️
#preprints #biorxiv #medrxiv

And what happens when a formerly trusted repository is no longer reliable?

This brings up the dilemma of “what defines a trusted repository?”

Don’t miss this opportunity! Please share with recent PhD grads or students who will soon graduate

So, there was a goal of trying to get away from relying on the print/PDF format. Unfortunately, execution of the original vision was limited.

Overall, I agree that it is time to move past all of this so that data associated with a paper are presented in the most useable manner.

The original intent (~15 yrs ago) was for a 1:1 correspondence with main figs. This is the unintended consequence of that and a specific “feature” at Cell where sup figs display in the HTML with the corresponding main fig. Other CP journals often let this slide b/c they only have sup figs in PDF.

I’ll let you go on “blave” since it is a fictional word

Sunday, Dec 14th New York Time Spelling Bee puzzle rejecting the word “inviable” as a potential answer despite it being both a real word and a perfect pangram for today’s puzzle.

@nytimes.com why not?

Impressive! Clever approach.

Congrats to the winners!

I had an inside view of how the Arc team managed this competition since June. They were super-responsive to the competitors, handling questions and concerns in a transparent manner as they arose.while also doing their “day jobs”.

a sign that says we 're hiring in orange on a white background ALT: a sign that says we 're hiring in orange on a white background

Nature Methods is hiring! We are looking for candidates with expertise in genetics, genomics and/or molecular biology to join our editorial team in the US (NYC/Jersey City) or China (Shanghai/Beijing). Apply by December 12!

springernature.wd3.myworkdayjobs.com/SpringerNatu...

In Memoriam: Bert W. O'Malley, M.D. In Memoriam: Bert W. O'Malley, M.D....

A true legend.
www.bcm.edu/about-us/lea...

Work published today in @natbiotech.nature.com from Arc’s Luke Gilbert and Patrick Hsu labs presents a new way to insert large DNA sequences into the genome using engineered recombinases that don’t require DNA cutting or rely on the cell's repair machinery.