Tom Brett

A little time off the grid….

James Harrison, whose blood donations saved over 2 million babies, has died Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.

Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.

George was a great guy. I vividly remember meeting him at a mixer at the IUCr meeting in Seattle in '97 when I was a grad student. We had an hour long conversation about SHELX and crystallography and other things over beers. Both a deep thinker and down to earth guy. He leaves a big impact.

Fun fact about George Sheldrick: he wrote a paper on his SHELX software (that everyone uses for small molecule crystallography) in Acta Cryst A which caused the journal to go from Impact Factor 2 to an IF = 50. Spawned discussion on the relevance of IFs. Huge impact.

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular Neurodegeneration TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee...

Mapping Trem2 ligand interactions by the group who brought us the first Trem2 crystal structure @tombrettlab.bsky.social

Right about now wondering how many Trump voters work at Universities in:
Facilities Management
Environmental Services
Construction/renovation projects (including steel workers, HVAC, electrical, plumbing, painters)
Large equipment installation or repair
Security
IT
Need I go on…..

One of the joys of mentoring is getting a glimpse into your students “outside the lab” life. Got to see the amazing #LNYF25 performance including our amazing undergrad researcher Cynthia Zhi!

Beautiful day for a snow hike with @jablab3.bsky.social ! Really amazing out there today!

Almost all the work done by undergrads! Thanks to #AlzheimersAssociation and #BrightFocus and #NIH #NIA for support! #EndAlz !

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular Neurodegeneration TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee...

I am so thrilled to share our latest collab with @jablab3.bsky.social ! Structural mapping of #TREM2 ligand interactions by #BLI. Led by Jessica Greven; thanks to big contributions by Josh Wydra, Cynthia Zhi,...
molecularneurodegeneration.biomedcentral.com/articles/10....

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular Neurodegeneration TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee...

Check out the latest from our groups on TREM2, driven by rockstar postbac Jess Greven and @tombrettlab.bsky.social!
@washumedicine.bsky.social

doi.org/10.1186/s130...

As a Minnesota native, I can’t pass up the opportunity for a snow run! Nice storm out there!

Fuck yes! Go Vikes!

Drake preference meme - new year, new me vs new year new memes

Right, fun’s over, back to our regularly scheduled programming.

Mug-ception

a person is typing on a keyboard with the words deleting delete intensifies ALT: a person is typing on a keyboard with the words deleting delete intensifies

You know how the emails pile up over the holidays, and when you clean your inbox out by quick screen/delete, you hope you didn't get rid of something important? Just found out we @jablab3.bsky.social had a big paper accepted a week ago because the notice got deleted. Happy discoveries!

Achievement unlocked! Chestnuts roasted on an open fire! Happy New Year to all!

Had the opportunity tonight to say Hi to my ‘baby blue’

Photo credit in image, I NEED to see this bird that is reportedly in the area.

Happy Christmas!🎄

Harnessing Mesenchymal Stem Cells for Improving Lung Transplant Outcomes

Ok, finally a science post for BlueSky: Check out our latest editorial in @TheJHLT, strong work as always from Ghandi (@Ghandi_Hassan_ on X)
www.sciencedirect.com/science/arti...

Jim Manley trumpet at Jazz STL

Tomorrow night. Let it SKOL.

#WinterWhiteout ❄️

You, sir, are a truely great American.

could you include me/ thanks

Brain endothelial GSDMD activation mediates inflammatory BBB breakdown - Nature Lipopolysaccharide-induced breakdown of the blood–brain barrier requires activation of GSDMD-mediated plasma membrane permeabilization and pyroptosis in brain endothelial cells.

www.nature.com/articles/s41...

He doesn’t get it. That’s ok. Fellow karaoke enthusiasts IYKYK ❤️ 🎤

👀!!!