More broadly, they suggest that phase separation may serve as a sensing and actuation mechanism to ensure proper expression of developmental regulators under seasonally appropriate conditions.
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Additionally, we found that SUF4 condensates can colocalize with other known FLC regulators, including FRI and ELF7. Together, these findings support the hypothesis that SUF4 phase separation provides a physical mechanism for regulating FLC expression and flowering.
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By progressively altering SUF4’s phase behavior, we found that we could tune SUF4's ability to bind the FLC promoter, modulate FLC transcription, and ultimately flowering time.
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TL;DR: We show that the IDP SUF4 forms temperature-dependent nuclear condensates in plants that correlate with transcriptional activation of the floral repressor FLC.
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Happy New Year! Looking forward to doing some science with you all!
01.01.2025 13:43 — 👍 1 🔁 0 💬 0 📌 0
Reminder that if disordered proteins are your thing, this starter pack exists (and I try to update it as best I can as new folks reach out/I see them!) 🍝
go.bsky.app/J23B51L
02.12.2024 06:00 — 👍 66 🔁 20 💬 10 📌 1
Are you interested in the role of protein condensation in plant biology? Come work with me at Syracuse University!
01.12.2024 18:23 — 👍 8 🔁 5 💬 0 📌 0
Are you interested in the role of protein condensation in plant biology? Come work with me at Syracuse University!
01.12.2024 18:23 — 👍 8 🔁 5 💬 0 📌 0
Cell Press partners with scientists across all disciplines to publish and share work that will inspire future directions in research. #ScienceThatInspires
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Associate Professor @YaleNeuro • co-Director of Graduate Studies @Yale_INP • @YaleRNA • RNA Neurobiology • Neurodegenerative disease • Immigrant • 🐶 dad • Alum @WhiteheadInst @HopkinsNeuro @PKU1898 🏳️🌈
Biophotonics, Biophysics & Innovation
@KITkarlsruhe
Assistant Professor of Molecular Biology, Center for Alzheimer's and Neurodegenerative Diseases, UT Southwestern. My lab studies damaged things. Sometimes we fix them. Hiring! Write if interested in postdoc or tech position. https://www.davidwsanders.com
Phase separation and disordered proteins!
Mom, Scientist, Equestrian and Artist.
www.hehnlylab.com
Assistant Professor at UNC Biochemistry and Biophysics. Unraveling mysteries of disordered and dynamic proteins with NMR and biophysics. Views are my own.
www.berlowlab.org
Professor of Computational and Molecular Biophysics at Cambridge University. We work on multiscale modeling of chromatin and biomolecular condensates. From Mexico City 🇲🇽. Mum of two (She/Her)
Membraneless Organelles in Bacteria: Structure, Dynamics, Function, and Engineering. Assistant Professor @scripps.edu.
https://laskerlab.org/
(he/him/his) Biological chemist / enzymologist studying protein lipidation; ghrelin enthusiast; Father/Husband; Cubs Fan #FirstGen
Cell biologist interested in macromolecular assembly and transport, from molecules to organisms 🌊 🏊♂️
Assistant Professor at UTSW studying nuclear organization by nuclear condensates
What does it feel like in a cell? SciComm, Art, Mental Health ScienceSketches.org
Asst. prof at Northwestern ChBE
Interested in how molecules and processes are organized and regulated in living cells | physics, math, engineering, and computation (mostly) for biology
shrinivaslab.com
Postdoc in Miller lab @UoDundeeLifeSciences.
Previous: #MSCAFellow @MRC_LMB; PhD @YaleChem; CCME @PKU1898
IDP/IDRs, membrane traffic, protein dynamics, evolution.
https://scholar.google.com/citations?user=-kHbQqwAAAAJ&hl=en
Studying the cell nucleus in search of inspiration for future DNA computers. Systems Biology professor at Karlsruhe Institute of Technology, post opinions mine alone.
hilbertlab.org
Solid-state NMR, Zernike Institute, university of Groningen. Posts = personal. Spectroscopy, biochemistry, structural biology, amyloid &
condensates, Huntington disease, membrane biophysics, biomaterials etc
