Benoit Bruneau

A minor league hockey team had a wiener dog race. Zero thoughts, just vibes and absolute chaos. A thing of beauty

Oh yeah let’s get HEALTHY!

Susur, King St Toronto.

since these deletions are heterozygous de novo SV, dosage-sensitive organization of 3D chromatin is likely an important genomic mechanism for CHD and perhaps other developmental disorders. Comments welcome!

RNAseq showed that many local heart development genes were affected by the deletions, one SV as small as 68bp. Other genes related to the etiology of the patients had changed expression. Overall, we propose that machine learning can be used to streamline the detection of SV pathogenicity, and 4/x

SVs predicted to alter 3D chromatin were more often associated with CHD than controls. In our lab we engineered iPS cells to harbour 3 of these deletions, and Capture-HiC showed that the predictions were correct! Sorcery in my view! 3/x

graduate student Maureen Pittman used a version of @gfudenberg.bsky.social's Akita, later re-trained on cardiac diffs from our lab (now called CardioAkita) to predict structural variants in the genomes of patients with congenital heart disease that would alter 3D chromatin organization 2/x

latest preprint just dropped! From a fantastic collaboration between our lab and Katie Pollard's @gladstoneinst.bsky.social. @ucsanfrancisco.bsky.social graduate student Jodi Lee jodilee539.bsky.social and Gladstone postdoc Jingshing Wu led the project www.biorxiv.org/content/10.6... 1/x

I am presenting our CODA platform in its glorious versatility tomorrow at the Kavli NDI Center at 9 am Clark Hall 316, Johns Hopkins University.

I will talk about CODA applications in oncology, neuroscience, developmental biology.

CODA maps whole organs and organisms at single-cell resolution.

“I will be too tired. I am going back to bed.”

Toad went back into the house.

Yesterday was slow cooker butter chicken with rice vinegar pickled cubes. End result:

"it's not political speech, thank you for your input though". We are free to attend these rallies at our place, even encouraged

AAAAAAAAAAAAAAAAAAAAAAAHHHHHHHHH

ANGEL CRISIS, by Zora Jones 6 track album

wow this new Zora Jones album is something else! zorajones.bandcamp.com/album/angel-...

Amaizeing

Final week to apply!

PUMAS is designed specifically for community college students ready to gain hands-on research experience at Gladstone.

Don’t miss this opportunity to spend your summer in the lab learning from world-class scientists.

Apply now ➡️ https://bit.ly/2UVIaST

aspirational

Apply to become a Preprint Editor Development

We are inviting experienced researchers to apply to become Preprint Editors, a new type of editorial role responsible for handling our 'In preprints' articles and forging links with preprint literature. #prepints

Learn more and apply before 30 March 2026:
journals.biologists.com/dev/pages/pr...

AAAHHHHHHHHH

didn't expect the slamming on the oven ceiling

The lawn chair knocked over meme. Green lawn, white chair and table, one is knocked over. Text “the great Nebraska earthquake of 2026 we will rebuild”

We survived a 4.0+!

Column | What science says we’ve been getting wrong about exercise Doctors and physiologists point to studies that show tiny, regular bursts of effort — like climbing a few stairs — can capture many of the benefits of the gym.

I like this article because my house has 65 steps, from driveway to bedroom. Fifty from home office to the top. Often I forget my keys upstairs... back up I go! So maybe that's all I need: live at home, forget stuff, up for dinner, down and back up after. www.washingtonpost.com/health/2026/...

This is brilliant

That's right. Worse than Pointless
www.nytimes.com/2026/02/23/o...

"a striking departure from usual...", "highly unusual...", "against usual norms", "going against tradition": can there be a harder set of terms to not gloss over illegal and amoral behaviour by certain individuals?

explosion sounds around here. Anyone know what this is?

Sleepy owl found resting among items on a New York antique store shelf Shoppers in upstate New York month turned up a rare find while perusing a local antique store this month: a live owl resting peacefully among items on a shelf.

Who?

While we sit around to find out how bad exactly it all is, a bit of cheer: the best baguette of Paris competition was won by a Sri Lankan who appears to have started as a dish washer in restaurants and eventually trained as a Boulanger.

www.paris.fr/pages/la-mei...

I already need a change of subjects from politics so here it is, Clingy Dogs.

Tony