Edoardo Sozzi's Avatar

Edoardo Sozzi

@edo-sozzi.bsky.social

Postdoc @ethz.ch Barbara Treutlein Lab | PhD โ€ช@Lund university Malin Parmar Lab | Human brain development, single cell sequencing, cell replacement therapy ๐Ÿง ๐Ÿงซ๐Ÿงฌ

57 Followers  |  137 Following  |  4 Posts  |  Joined: 09.08.2025  |  1.4092

Latest posts by edo-sozzi.bsky.social on Bluesky

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Three-dimensional co-culturing reveals human stem cell-derived somatostatin interneurons with subclass expression Rylander and colleagues present a 3D co-culture model for successful generation and maturation of somatostatin interneurons from human embryonic stem cells. This system reveals previously uncharacteri...

Out now in Stem Cell Reports! โœจ

In this work we present a 3D co-culture system for the generation of human somatostatin (SST) interneurons ๐Ÿง 

๐Ÿ“„ Read the full paper here:
www.cell.com/stem-cell-re...

12.09.2025 16:18 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Nuclei Isolation Protocol for Single-Nucleus RNA Sequencing of Human Stem Cell-Derived Grafts Single-nucleus RNA sequencing enables high-resolution transcriptomic profiling of brain tissue, facilitating detailed analysis of cell identity in models of neurodegeneration and repair. Here, we desc...

๐Ÿš€ New preprint alert!
We developed a workflow to isolate nuclei from human stem cell-derived grafts in the rat brain for single-nucleus RNA-seq. This approach helps uncover how transplanted progenitors develop into mature neurons in vivo ๐ŸŒŸ
Check it out here: www.biorxiv.org/content/10.1...

08.09.2025 17:57 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Exciting news in Huntingtonโ€™s disease research! Transplanted human striatal progenitors can functionally integrate and modulate host brain circuits in a Huntingtonโ€™s disease animal model - a promising step toward cell based therapy!

Full story: lnkd.in/dzgNb3-R

26.08.2025 06:47 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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6 months ago I defended my PhD thesis, and looking back it feels both close and far away - so much has happened since then! Thanks to everyone who shared this journey with me, especially my supervisors Malin, Alessandro and Daniella, and also my opponent Gonรงalo.

Onwards!

18.08.2025 17:15 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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How can ventral midbrain #organoid derived from human pluripotent stem cells help to understand the #dopaminergic system and its pathologies?
@fiorenzano.bsky.social and collaborators review recent advances, remaining challenges, and emerging opportunities
www.embopress.org/doi/full/10....

02.07.2025 12:01 โ€” ๐Ÿ‘ 6    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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