Kurianlab

jobs.lever.co/arcadiascien...

Cryo-EM structures of Egl–BicD–RNA complexes reveal how diverse mRNAs are selected for subcellular localization Localization of mRNAs is a widespread mechanism for controlling where proteins operate in cells and underpins many fundamental processes, from embryonic patterning to synaptic plasticity. This spatial...

www.biorxiv.org/content/10.1...

Very cool

For early career scientists/ group leaders, to transition to professorship:

hector-fellow-academy.de/en/career-de...

Faculty Position in Life Science Engineering The School of Life Sciences at EPFL invites applications for a faculty position in life science engineering. Appointments will be at Tenure Track Assistant Professor or at Associate Professor level. W...

Outstanding Faculty opportunity in the broad area of 'life sciences engineering' @EPFL School of Life Sciences, open to both junior and senior researchers. We may prefer metabolism-centric applications but remain open to outstanding applications across domains:
www.epfl.ch/about/workin...

A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies - Nature Communications Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a wide variety of cell and ti...

*Djuranoviclab recently developed RAPPL:

www.nature.com/articles/s41...

*Seminar Alert*

Prof. Sergej Djuranovic, PhD
Brown University, USA

Date: 02.09.2025. 15:00

Venue: Faculty of Medicine, Goethe University, Seminar room 4, Haus 23 (S23-4)

@djuranoviclab.bsky.social
@cpi-exstra.bsky.social
@scale-cluster-ffm.bsky.social
@goetheuni.bsky.social

A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

www.nature.com/articles/s41...

RNA triggers chronic stress during neuronal aging Neurodegenerative diseases are linked with dysregulation of the integrated stress response (ISR), which coordinates cellular homeostasis during and after stress events. Cellular stress can arise from ...

www.biorxiv.org/content/10.1...

Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines - Nature Methods The analysis presented in this Brief Communication shows that, despite their complexity, current deep learning models do not outperform linear baselines in predicting gene perturbation effects, thus e...

Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines

www.nature.com/articles/s41...

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...

www.nature.com/articles/s41...

Check this fantatsic paper about fast, label free, effecient isolation of intact ribosomes: RAPPL

Congtrats Slavica and Sergej!!

Pathway to Independence – an interview with Joaquín Navajas Acedo Joaquín Navajas Acedo is a Postdoc in the lab of Dr Alexander Schier in Biozentrum at the University of Basel, Switzerland. He is interested in how the nervous system evolves and develops at the singl...

In case you've ever wondered, I talked with @amjeve.bsky.social about science, myself, and the future of #DevBio as part of the Pathway to Independence Fellowship @biologists.bsky.social 🧪 journals.biologists.com/dev/article/...

Iterative recombinase technologies for efficient and precise genome engineering across kilobase to megabase scales Genome editing technologies face challenges in achieving precise, large-scale DNA manipulations in higher organisms, including inefficiency, limited e…

www.sciencedirect.com/science/arti...

Check this: A scar-free strategy enables seamless editing of multi MB regions without residual sequences

Brief summary of our lab work and mission! So much more to do!

Escherichia coli with a 57-codon genetic code The near-universal genetic code uses 64 codons to encode the 20 canonical amino acids and protein synthesis. Here we designed and generated Escherichia coli with a 4 Mb synthetic genome in which we re...

www.science.org/doi/10.1126/...

👆

I’m happy that research and development in Germany 🇩🇪 are striving - still so many things to do adopt an open and inclusive culture at German universities.

Ribo-ITP expands the translatome of limited input samples In the last decade, an unexpectedly large number of translated regions (translons) have been discovered using ribosome profiling and proteomics. Translons can regulate mRNA translation and encode micr...

www.biorxiv.org/content/10.1...

From Can Cenik lab

Congrats Guille!

Ageing-associated endothelial decorin induction and the impact of non-glycanated decorin on cardiac inflammation AbstractAims. Cardiovascular disease is the leading cause of death in the European Union and aging is one of its major risk factors resulting in the progre

That's how I like to start the summer! Our story identifying decorin as a novel player in cardiovascular ageing just got published in #CardiovascularResearch 💃🏻💃🏻 Congratulations to all authors and thanks to @ekfstiftung.bsky.social that made this study possible academic.oup.com/cardiovascre...

🎉 To mark the fourth extension of the CPI, we celebrated our success at the @mpi-hlr.bsky.social 🥳 We are delighted about the renewed funding and would like to thank everyone who made this step possible! Read more in the latest issue of "Synapse": www.unimedizin-ffm.de/fileadmin/re...

Structure-Guided Design of a Bioactive Covalent Small Molecule Targeting a Riboswitch Small molecule ligands targeting structured RNA elements hold promise for modulating RNA function, serving as chemical probes and potential therapeutics. In this study, the characterization of phenylg...

www.biorxiv.org/content/10.1...

Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial Membrane-anchored HIV envelope trimer mRNA vaccines elicited high response rates of serum autologous tier 2 neutralizing antibodies in humans.

Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial
www.science.org/doi/10.1126/...

Postdoctoral fellow

📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline August 31: www.ugent.be/en/work/scie...

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

www.nature.com/articles/s41...

☝🏽

Design of highly functional genome editors by modelling CRISPR–Cas sequences - Nature Gene editors designed using artificial intelligence can undertake precision editing of the human genome.

www.nature.com/articles/s41...

We developed MouseMapper AI, a deep learning ensemble for the analysis of whole-body systems, including the nervous and immune systems, to map disease/drug perturbations tissue by tissue, organ by organ, at the cellular level in 3D.
biorxiv.org/content/10.1...

Identification of conserved RNA regulatory switches in living cells using RNA secondary structure ensemble mapping and covariation analysis - Nature Biotechnology Transcriptome-scale maps of RNA secondary structure ensembles in living cells detect candidate RNA structural switches.

I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in
@natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)

:)

A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.

www.nature.com/articles/s41...