Tom Grossmann

Stabilizing Proteins by Chemical Cross-Linking: Insights into Conformation, Unfolding, and Aggregation Using Native Ion Mobility Mass Spectrometry The function and stability of proteins depend on their three-dimensional structure, which includes conformational dynamics and potential self-assembly. Protein structural organization is particularly ...

Stabilizing Proteins by Chemical Cross-Linking: Insights into Conformation, Unfolding, and Aggregation Using Native Ion Mobility Mass Spectrometry #AC pubs.acs.org/doi/10.1021/...

After a decade @vuamsterdam.bsky.social I’m excited to share that I’m starting @uni-goettingen.de‬

I’m incredibly grateful for my supportive colleagues at the VU and looking now forward to the opportunities ahead. Big THANKS to everyone in the group who supported our research over the years!

Greetings from the GRC on Artificial Molecular Switches and Motors! It’s exciting to see how the field has grown and is moving toward everyday applications—think photoswitchable tattoos!

Great to see our Highlight Review on TAV2b-derived RNA modulators online at Chemistry Letters doi.org/10.1093/chem...

Congrats to first author Marvin Albers! Read more about our RNA-targeting strategies also here:
-> doi.org/10.1002/anie...
-> doi.org/10.1093/nar/...
-> doi.org/10.1002/chem...

Now that our new @jacs.acspublications.org paper is printed, let me show you what's so cool about the group B [FeFe]-hydrogenase from Thermosediminibacter oceani (ToHydA) 😎
doi.org/10.1021/jacs...

Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes Phosphodiester groups occur ubiquitously in nature, e.g. in nucleic acids or in cyclic (di-)nucleotides important for signal transduction. Proteins often use polar or positively charged amino acids t...

You thought Glu/Asp don't like RNA or DNA? Maybe you even introduced them into your protein to stop such interactions?
😱🧪
Think again! New paper @angewandtechemie.bsky.social with Wöhnert lab shows structural context matters for phosphodiester interactions!
onlinelibrary.wiley.com/doi/10.1002/...

Insights into the surface chemistry of N-heterocyclic carbenes N-heterocyclic carbenes (NHCs) have emerged as a versatile and powerful class of ligands in surface chemistry, offering remarkable stability and tunability when bound to surfaces, including metals, me...

🚨 Hot off the press in @ChemSocRev!
A must-read tutorial review on N-heterocyclic carbenes (NHCs) on surfaces.
📄 "Insights into the surface chemistry of NHCs"
👇 Dive in: pubs.rsc.org/en/content/a...
#SurfaceChemistry 👩‍🔬✨

Great to see our paper on helicity-dependent peptide cyclizations online at the Journal of Peptide Science doi.org/10.1002/psc.... (open access)

Congrats to all authors!! #peptidomimetics

Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa–Burkholderia cenocepacia Infections: A Biophysical Study Chronic lung infections caused by Pseudomonas aeruginosa and Burkholderia cenocepacia pose a severe threat to immunocompromised patients, particularly those with cystic fibrosis. These pathogens often...

Happy to share our latest #glycotime work with Sarah, Annabelle and @mariofares.bsky.social Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa–Burkholderia cenocepacia Infections @pubs.acs.org |Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...

Peptide catalysis: Trends and opportunities Peptides are highly selective organocatalysts, with intrinsic modularity allowing precise control over structure and function. Advances in peptide synthesis, biotechnology, and cheminformatics will en...

🎉 Big day for our group: our first publication is out!
Tom did a fantastic job highlighting current trends & opportunities in peptide catalysis — now published in Chem Catalysis (open access). Huge congrats, Tom!
www.cell.com/chem-catalys...

NMR-Based Measurements of Site-Specific Electrostatic Potentials of Histone Tails in Nucleosome Core Particles Electrostatics play a dominant role in guiding many biological processes. This is especially the case in the context of chromatin, where charge interactions modulate diverse activities such as DNA rep...

Check out Nick & @roesslph.bsky.social work on nucleosome electrostatics! More to come shortly 👀

#NMRchat

Structure of the ATP-driven methyl-coenzyme M reductase activation complex - Nature The structure and function of the MCR activation complex from Methanococcus maripaludis were revealed, demonstrating its ATP-dependent ability to activate MCR and form methane while uncovering a uniqu...

One of the largest open questions in anaerobic metabolism solved. The best work of my lab yet, performed by the incredible hard working, talented and motivated coworkers: @fidelormz.bsky.social , @sophia-pa.bsky.social and @rnfr2d2.bsky.social. I am a proud PI today!
www.nature.com/articles/s41...

Hi! Our lab has moved to Bluesky! We will discontinue our Twitter presence in the near future, so please watch out our news here!

Did you enjoy the amazing #ABPP2025 meeting? Or were you sad that you could not attend?

If so, we are happy to announce that the next iteration of the meeting will happen in beautiful Leiden in The Netherlands in 2027. Keep an eye on this space, to be the first one to learn more. (1/2)

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning - Nature Neuroscience Researchers developed DELTA, a method for brain-wide measurement of synaptic protein turnover with single-synapse resolution, providing a powerful tool to localize and study mechanisms underlying syna...

Honored to help enable two back-to-back papers in @natureneuro.bsky.social; first DELTA www.nature.com/articles/s41... with collaborators at @hhmijanelia.bsky.social and then EPSILON www.nature.com/articles/s41... with @adamezracohen.bsky.social; @dyerfulchymist.bsky.social is always in the mix!

What a superb and inspiring day, discussing highly diverse aspects of #Bioinspiration - A big thank to all the speakers, chairpersons, and the attendance. As well as the people involved in the organization...

Advances in Bioinspirations

@inserm.fr - @cea.fr - @cnrs.fr

#BMSV

Make sure not to miss our latest paper out now in #JACS - presenting eSylites - small, peptide-based probes for precise mapping of neurons, etc.!

Microscale thermophoresis (MST) played a huge part in optimizing the probes structure and sequence for binding affinity.

#ChemicalBiology #Synapse

Axonal RNA localization is essential for long-term memory - Nature Communications Axonal transcriptomes have been characterized, but their regulation and role in neuronal circuits remain unclear. Here authors uncover activity-dependent RNA localization in axons important for memory...

From the Besse's lab.
#RNAbiology #RNAlocalization #spatialbiology

www.nature.com/articles/s41...

Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern Bispecific antibodies incorporating a cross-reactive NTD-specific antibody are resilient to SARS-CoV-2 variants of concern.

Wow, major breakthrough in the development of broadly neutralizing bispecific antibody therapeutics against SARS-CoV-2, led by @stanford-chemh.bsky.social institute scholar @cobarnes27.bsky.social 😃

www.science.org/doi/10.1126/...

Beyond excited to announce our in-person symposium to celebrate the 25th anniversary of ChemBioChem/ChemPhysChem!

Advances in Structural Analysis of Biomolecules
From Subcellular Imaging to Drug Design

October 23-24, 2025, Berlin

Please like and share: cbc-cpc2025.org

Induced proximity pushes beyond protein degraders, as first RIPTAC moves into the clinic Halda Therapeutics has started a clinical trial of its first-in-modality RIPTAC drug HLD-0915 in prostate cancer, to see if bifunctional drugs can provide tissue-specific activity.

www.nature.com/articles/d41... #RIPTACs

DNA Mimic Foldamer Recognition of a Chromosomal Protein Biomolecular mimics are intended to outperform their natural counterparts. However, B-DNA surface mimicry to target DNA-binding proteins has long remained underdeveloped. We have introduced helical a...

Please check out our Angew. communication on DNA mimic foldamers that can outcompete DNA itself in the binding of proteins! 🧬

onlinelibrary.wiley.com/doi/full/10....

I'm pleased to share our latest paper with our wonderful collaborators in the Lombardi lab on a biocatalyst for selective CO2 reduction: pubs.rsc.org/en/content/a...

Follow all your favorite @rsc.org journals now on Bluesky! Let the posting begin! 🥳🧪 #chemsky go.bsky.app/QAaTTZ3

It's out!
Beautiful work led by Loreto Oyarte Gálvez & @cbisot.bsky.social!
Do you want to learn more about how Mycorrhizal fungi extraordinary networks form and function? Read the open-access publication! Link below 👇

Congrats @dianamelis.bsky.social for her article in @chemicalscience.rsc.org. We describe the 1st use of bioorthogonal click chemistry with 188Re for radiolabelling of an anti-c-Met VHH Nanobody®. Great collaboration with the Opsomer/Ooms group
@chimieparistechpsl.bsky.social
doi.org/10.1039/D4SC...

Halda Therapeutics Announces First Patient Dosed in Phase 1/2 Clinical Trial Evaluating HLD-0915 in Metastatic Castration-Resistant Prostate Cancer - Halda Therapeutics First-in-human clinical trial to evaluate safety and tolerability of a new class of small molecule medicines for the treatment of cancer, RIPTAC™ therapeutics NEW HAVEN, CT, February 24, 2025 – Halda ...

First RIPTAC dosed in humans! #RIPTACs #prostatecancer
haldatx.com/halda-therap...

A nucleosome switch primes hepatitis B virus infection A reconstituted cccDNA platform facilitated the discovery of an early chromatinization event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene. The use of a small-molecule c...

I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social

From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵

www.cell.com/cell/fulltex...

Reaction development: a student's checklist So you’ve discovered a reaction. But how do you turn this new discovery into a fully-fledged program that maximises the potential of your novel transformation? Herein, we provide a student's checklist...

Scholarly review written by @DirkTrauner and @GloriusGroup:

Reaction development: a student's checklist📜☑️😀

Published in Chem. Soc. Rev.
doi.org/10.1039/d4cs...

Last week, we ran again the SciX program at #UNSW! Fantastic enthusiasm by 150 senior high school students diving into the world of #science and #engineering. Shoutout to all involved who made this possible and a success!
#SciX25 #3DBioprinting @UNSWScience @UNSWEngineering @UNSWChemEng