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Harrison Specht

@harrisons.bsky.social

Exploring biology with mass spectrometry

900 Followers  |  522 Following  |  85 Posts  |  Joined: 05.10.2023
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Posts by Harrison Specht (@harrisons.bsky.social)

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Pioneer and Altimeter: Fast Analysis of DIA Proteomics Data Optimized for Narrow Isolation Windows www.biorxiv.org/cont...

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#proteomics #prot-preprint

19.02.2026 10:20 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Spatial Proteomics Workshop for Protists

(see more in thread below)

Registration
Early Bird Monday 22nd June 2026.
Regular Monday 10th August 2026.
There will be a conference dinner on day 1. To register visit protistology.org.uk/autumn-meeti...

06.02.2026 18:11 β€” πŸ‘ 25    πŸ” 17    πŸ’¬ 1    πŸ“Œ 0

Agreed on both.

04.02.2026 19:41 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Aside from the whisper network, how are #teammassspec finding out how much certain instrument models are down for (service delays, backordered parts, things breaking all the time, etc)?

03.02.2026 08:46 β€” πŸ‘ 9    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0
May Institute – Computation and statistics for mass spectrometry and proteomics

Applications are now open for @olgavitek.bsky.social 's May Intitute on computation and statistics for mass spectrometry and proteomics at @northeasternu.bsky.social !

--> computationalproteomics.khoury.northeastern.edu

20.01.2026 23:26 β€” πŸ‘ 20    πŸ” 13    πŸ’¬ 1    πŸ“Œ 0
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#AminoAcidAdvent Day 6: Cysteine (Cys; C)

Like Mork & Mindy, these stinky residues love to bond! Jerks like us break these bonds, with chemoproteomics trying to map, probe, and manipulate them. Leftovers stuck to S-S is a fun field but I love them for their antioxidant and metal binding abilities.

09.12.2025 13:41 β€” πŸ‘ 15    πŸ” 4    πŸ’¬ 1    πŸ“Œ 1
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Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park!
β€œSpecialized gas-exchange endothelium of the zebrafish gill” β€”

www.biorxiv.org/content/10.6...

Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)

02.12.2025 22:48 β€” πŸ‘ 2220    πŸ” 327    πŸ’¬ 35    πŸ“Œ 21
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The 2026 Chemistry Faculty Jobs List

The 2026 Chemistry Faculty Jobs List has 330 tenure-track positions and 47 teaching-only positions: docs.google.com/spreadsheets... #facultychemjobs #chemsky #chemchat βš—οΈπŸ§ͺ

25.11.2025 19:56 β€” πŸ‘ 16    πŸ” 10    πŸ’¬ 1    πŸ“Œ 0

one of the coolest things about ChatGPT is how you can actually just never use it. you can fill your whole entire life with simply not once using it. it's incredible.

25.11.2025 16:15 β€” πŸ‘ 23061    πŸ” 6615    πŸ’¬ 249    πŸ“Œ 285

So which AI peer review tool can tell me authors gave all the Code to make their Figures? πŸ§ͺ

βœ… Code uses right functions for plot type in Figure?

βœ… Is there a 1:1 correspondence between Code and Figures?

❌ Automated reanalysis --> IMO this requires expert knowledge to know the data wasn't hacked

21.11.2025 15:29 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Proteomics + an elegant mechanism! I cannot wait to read in full! #proteomics #TeamMassSpec πŸ§ͺ

17.11.2025 14:54 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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No one is immune to aging but what exactly happens to our immune system as it ages? @thibaultcolombani.bsky.social takes a molecular dive into the immune system and talks about understanding age-induced immune altercations through single-cell proteomics.

www.youtube.com/watch?v=WUU1...

13.11.2025 19:02 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Barcodes and the future of measuring proteins - PTI - Parallel Squared Technology Institute Increasing the rate at which we measure proteins increases the rate at which we can discover new biology and solve disease.

Check out our new blog post on barcodes and the future of quickly measuring proteins for biomedical research! πŸ§ͺ

www.parallelsq.org/blog/barcode...

12.11.2025 15:14 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Koina: Democratizing machine learning for proteomics research - Nature Communications Koina is an open-source, online platform that simplifies access to machine learning models in proteomics, enabling easier integration into analysis tools and helping researchers adopt and reuse ML mod...

Exited to share our latest work! Out now in @natcomms.nature.com

Koina aims to transform how #proteomics uses machine learning. You no longer need to be a tech wizard to use ML and now can easily run #ML models. Integrated with FragPipe, Skyline and EncyclopeDIA!

www.nature.com/articles/s41...

11.11.2025 20:06 β€” πŸ‘ 36    πŸ” 15    πŸ’¬ 0    πŸ“Œ 1

May Institute on Computation & Statistics for MS and Proteomics is taking great shape. Fantastic new and repeat instructors and lots of new content. We are grateful to our sponsors Fragmatics and Biognosys. Keep an eye on the website computationalproteomics.khoury.northeastern.edu

10.11.2025 16:39 β€” πŸ‘ 24    πŸ” 10    πŸ’¬ 0    πŸ“Œ 0

πŸ§ͺ Two of my favorite sci-things!

Already run q.e.d on my latest bioRxiv submissions :)

07.11.2025 12:57 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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R/Bioconductor for Mass Spectrometry and Proteomics Dates 17-19 November 2025 To foster international participation, this course will be held online

πŸŽ“ Upcoming Online Course: R/Bioconductor for Mass Spectrometry & Proteomics

πŸ“… November 17–19, 2025

Join Dr Laurent Gatto for a hands-on course on mass spectrometry–based proteomics analysis using R and Bioconductor.

πŸ‘‰ Register & learn more: www.physalia-courses.org/courses-work...

06.11.2025 10:00 β€” πŸ‘ 14    πŸ” 8    πŸ’¬ 0    πŸ“Œ 1

Thanks!

Not yet, but I wouldn't expect huge benefits over the default LF models unless you are trying some exotic chromatography, collision energies or additives.

04.11.2025 18:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Fantastic Proteins and Where to Find Them - PTI - Parallel Squared Technology Institute Here, we will offer a tutorial for how to build instrument-specific spectral library predictions for PSMtag modified peptides using DIA-NN 2.3.0. This will allow users to do more accurate proteome-wid...

#Proteomics Tutorial drop!

Had fun writing this, ping me if interested in other search engines. #TeamMassSpec

www.parallelsq.org/blog/fantast...

04.11.2025 16:46 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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How to design 1000-plex mass tags using the differential mass defect Multiplexing samples in mass spectrometry-based proteomics has long been accomplished by isotopologues of small molecules. These chemically-identical "mass tags" conjugate to peptides to encode sample...

A bit dense, but the important message is dead simple:

We got to cite the E = mcΒ² paper!

Kidding :)

The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.

Here's how: www.biorxiv.org/content/10.1...

#TeamMassSpec #Proteomics πŸ§ͺ

24.10.2025 14:08 β€” πŸ‘ 20    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1

πŸ§ͺπŸ”₯πŸ”₯πŸ”₯

22.10.2025 18:56 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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AlphaDIA enables DIA transfer learning for feature-free proteomics - Nature Biotechnology An open-source platform for data-independent acquisition proteomics adapts predicted libraries to experimental settings.

AlphaDIA enables DIA transfer learning for feature-free proteomics - @mannlab.bsky.social @jalew188.bsky.social go.nature.com/4qmEQMM

21.10.2025 16:53 β€” πŸ‘ 21    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

πŸ§ͺ I tried it and I'm happily surprised!

As long as it doesn't boil the oceans, I would run it on all new papers I read for:

🌎 Mapping the interrelatedness of claims -- papers are so complex now!

πŸ”¬ Calling out potential gaps -- so that I can know the experiments were properly controlled.

20.10.2025 21:37 β€” πŸ‘ 12    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
Jmod: Joint modeling of mass spectra for empowering mulitplexed DIA proteomics | Kevin McDonnell
YouTube video by Parallel Squared Technology Institute Jmod: Joint modeling of mass spectra for empowering mulitplexed DIA proteomics | Kevin McDonnell

And, we are back with another presentation from this year's Research Fest. PTI's Senior Computational Scientist, Kevin McDonnell, talks about developing joint modeling (aka JMod) of mass spectra for empowering multiplexed DIA proteomics.

www.youtube.com/watch?v=plK4...

16.10.2025 18:49 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Yes! This 100x over.

15.10.2025 18:57 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Well color me curious... and perfect choice of portrait πŸ˜‚

15.10.2025 13:47 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Good read, I learned a few new facts!

Where's the paragraph explaining WHY AI will not replace scientists ? πŸ§ͺ

The general audience would benefit from this.

14.10.2025 22:28 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

πŸ§ͺ

14.10.2025 16:28 β€” πŸ‘ 11    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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a teddy bear is standing in front of a blue door ALT: a teddy bear is standing in front of a blue door

Increasingly in favour of the Marie Kondo approach to collaborations in science. Does your collaborator spark joy? If not βž‘οΈβ™»οΈπŸ—‘οΈ

No one's skills or knowledge are so unique or indispensable that they get to make your day miserable with every interaction. πŸ§ͺπŸ”­

14.10.2025 17:27 β€” πŸ‘ 71    πŸ” 8    πŸ’¬ 2    πŸ“Œ 0

Parquet fans unite!

10.10.2025 18:40 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0