Julien GIRAUD

Many congratulations again ☺️🥳

Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors Martinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity genes whose protein products neutralize toxins secreted by competitors. These arrays, often linked to Xer pass...

Happy to share the last work of @jmartinkus.bsky.social, led by @dukasju.bsky.social
Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social
Kudos !!
www.cell.com/current-biol...

Fantastic work from the fantastic @maellepllt.bsky.social 😍

What if even the core of bacterial nanomachines wasn’t static?

We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.

🔗 www.nature.com/articles/s41...

@kit.edu @t3sss.bsky.social

Rosalind Franklin and the damage of gender harassment Spurred by a recent report on sexual harassment in academia, our columnist revisits a historical case and reflects on what has changed—and what hasn’t

Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...

Very proud to be part of an amazing organising committee, huge thanks to @maellepllt.bsky.social @cascaleslab.bsky.social @thicoz.bsky.social and Romé Voulhoux

Amazing science at the 2nd edition of the Secretion Days in Marseille 🌞 ! Huge thanks to all participants and to @archaellum.bsky.social for an outstanding opening talk. Looking forward to the next edition!

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...

Extremely happy to share the fruit of a beautiful collaborative research study.

France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺

Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇

doi.org/10.1101/2025...

Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins Bacterial polymorphic toxins are modular weapons that mediate inter-microbial competition and host interactions by delivering diverse cytotoxic domains through specialized secretion systems. Here, we ...

Happy to share our work on a T6SS effector with ADP ribose cyclase activity, published in JBC @asbmbjournals.bsky.social
Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social
www.jbc.org/article/S002...

Grateful to my PIs, team, collaborators, and colleagues for their support. Excited to share our paper from my PhD journey!

Open position !!
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...

We recently described how T3SS effectors reach the injectisome with a shuttle system. But what about their chaperones? With live microscopy, proximity labeling and functional assays, @keithpint.bsky.social showed the Yersinia chaperone SycH already hands over its cargo in the cytosol. bit.ly/47hq6rM

🚨🔥 Happy to share our latest Preprint! 🔥🚨

We describe some very simple experimental approaches employed in our group to assess CRISPRi effectiveness in Mycobacteria 🧬 🦠 🧫

Project co-led by Vanessa, Wafaa, Janïs & Eliana - Our Fantastic 4 Female Scientists💫🙌🧨

www.biorxiv.org/cgi/content/...

We have an open engineer position to work on type IX secretion (T9SS), under the supervision of @doan_thierry (collab with HP Fierobe & A. Tolonen). 1-year contract, renewable up to 3.5 years. Please apply here or forward to anyone potentially interested:

emploi.cnrs.fr/Offres/CDD/U...

Kicking off the week with exciting news:

🧐 There is still time to register and submit your abstract until 30th May for the 2nd edition of "Secretion Days" (October 2-3, Marseille).

💻Registration:
docs.google.com/forms/d/e/1FAI…

📩 More info: secretion@imm.cnrs.fr

@maellepllt.bsky.social; @cascaleslab.bsky.social; @thicoz.bsky.social @lcbofficiel.bsky.social @univ-amu.fr

Journées Sécrétion 2025 Contact: secretion@imm.cnrs.fr

👉Reminder : ONE WEEK LEFT👈
📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊
🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social
🆓 Free, spot are limited !
📥 Registration is open until May 20 via the following link: docs.google.com/forms/d/e/1F...

Journées Sécrétion 2025 Contact: secretion@imm.cnrs.fr

👉Don’t forget👈
📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊
🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social
🆓 Free, spot are limited !
📥 Registration is open until May 15 via the following link:
🔗 docs.google.com/forms/d/e/1F...

Hate de suivre ton périple instanbuliote…🌞

You are a young researcher working on the bacterial cell envelope ? Don't miss this opportunity !!

Thrilled and honored to join the organizing committee of the 2nd edition of the Journées Sécrétion!

We look forward to seeing you there, in Marseille🌞, reconnecting, and discovering exciting new research. See you soon!

The Journées Sécrétion are back!

2nd and 3rd October in Marseille

Keynote lecture by: @archaellum.bsky.social

Registration is open until May 15: forms.gle/2qxHntTktoxw...

Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social

Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌

@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social

We have an open PhD position to work on bacterial secretion systems. Please RT, write us or apply through the CNRS job portal:
t.co/HxX23Od1oa

Raconte-moi ta thèse #22 | L'invention des aventurières. Sociabilités, récits de soi et mobilités au féminin dans l'Europe du XVIIIe siècle, par Maxence Joscht | EHESS Alumni | Votre communauté ... Maxence Joscht est doctorant à l'EHESS au sein du Centre de recherche sur les circulations, les liens et les échanges (CeRCLEs - EHESS), sous la direction dEleonora Canepari....

Une médecin marchande d'esclaves, de fausses princesses, des voyageuses travesties parcourant l'Europe du XVIIIe siècle... Il est question de tout cela dans ce "Raconte-moi ta thèse" consacré à mes travaux de recherches au sein de l'EHESS.

À découvrir ici :

alumni-ehess.fr/fr/article/r...