Sara Valpione 🌻

The projected rise in global cancer deaths
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...

What if we could stop #Cancer before it even starts?

Prof. Sarah Blagden @oncology.ox.ac.uk & PPI contributor Anna Fry discuss novel cancer prevention research on the @oxfordsparks.bsky.social podcast.

🎧 www.oxfordsparks.ox.ac.uk/podcasts/cou...

@sarahblagden.bsky.social @medsci.ox.ac.uk

From Manchester for the world.

We are proud to launch our bold strategy to 2035. Together, we're redefining what a great civic University looks like for the 21st century.

Visit our webpage to explore our ambition in full: www.manchester.ac.uk/about/manche...

Levy on international students’ tuition fees not in best interest of UK, says leader of top university Duncan Ivison, president of Manchester University, says government’s 6% surcharge plan will ‘hurt the sector’

Levy on international students’ tuition fees not in best interest of UK, says @duncanivison.bsky.social, president and VC of @manchester.ac.uk
More from @theguardian.com
bit.ly/4r1save
#education #educationnews

Targeting the ac4C ‘Writer’ NAT10 enhances pancreatic cancer immunotherapy via dual modulation of CD8+ T cells and tumor cells - Cell Death & Disease Cell Death & Disease - Targeting the ac4C ‘Writer’ NAT10 enhances pancreatic cancer immunotherapy via dual modulation of CD8+ T cells and tumor cells

Targeting the ac4C ‘Writer’ NAT10 enhances #PancreaticCancer immunotherapy via dual modulation of CD8+ T cells and tumor cells 🔬 www.nature.com/articles/s41...

Neurogenic inducers inhibit the proliferation of pancreatic cancer by promoting tumor cell transdifferentiation - Journal of Experimental & Clinical Cancer Research Background Tumor cell differentiation is a critical determinant of malignancy and clinical treatment selection. Pancreatic ductal adenocarcinoma (PDAC), a poorly differentiated and highly aggressive t...

Neurogenic inducers inhibit the proliferation of #PancreaticCancer by promoting tumor cell transdifferentiation 🔬 jeccr.biomedcentral.com/articles/10....

⌛Just one week left to submit your applications for the Black Leaders in Cancer PhD programme in Scotland!

25 years ago, our scientists helped lay the groundwork for the HPV vaccine. Today, the world unites for the first official World Cervical Cancer Elimination Day. Together, we can achieve a world where almost nobody develops cervical cancer.

YouTube video by The Royal Society Why is biodiversity important - with Sir David Attenborough | The Royal Society

Global #biodiversity is under intense pressure from human activity. David Attenborough explains why biodiversity is so important to us, how biodiversity loss is impacting our world and how there is still time to change direction – if we act now: #COP30 https://www.youtube.com/watch?v=GlWNuzrqe7U

Now online in Cancer Discovery @aacrjournals.bsky.social: PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis - by Shuang Tang, Qian Zhou, Jean, Zhao, and colleagues doi.org/10.1158/2159... #FUSCC @danafarber.bsky.social

Ten days left to apply to be a @crick.ac.uk Early Career Group Leader

Closing date 27th November

www.crick.ac.uk/careers-stud...

Submit an abstract by December 1 for the AACR IO Conference on Discovery and Innovation in Cancer Immunology (February 18-21, 2026; Los Angeles), chaired by Nina Bhardwaj and Antoni Ribas. Learn more:
buff.ly/TUarANa
#AACRIO26

Postdoctoral Scientist- Kim and Abdus-Saboor Lab Primary Work Address: Dept of Molecular Biology, Princeton, NJ, 08544 Current HHMI Employees, click here to apply via your Workday account. The Kim Lab at Princeton University and Abdus-Saboor Lab at ...

Come do a joint postdoc with me and @tinakim-neuro.bsky.social, splitting your time between Princeton and Columbia. Come design new activity-dependent labeling enzymes and transcriptional reporters optimized for application in the peripheral nervous system.
hhmi.wd1.myworkdayjobs.com/en-US/Extern...

There's not long left for you to submit your abstract for Signalling Circuits in Cancer!

If your research falls into any of these categories, don't miss your opportunity to be included in this new conference topic.

eacr.org/conference/s...

Yang Y, et al. Remodeling of KRAS interactome induced by clinically relevant RAS inhibitors reveals convergent responses and a KRAS-mediated regulation of directional cell migration. bioRxiv posted 16 November 2025 doi:10.1101/2025.11.14.688534. www.biorxiv.org/content/10.1...

Also, here’s an accessible video intro:

🚀 Looking for a motivated postdoc in molecular biology! Apply for a Juan de la Cierva 2025 fellowship and join R'n'R lab in Madrid.
📅 PhD Jan'24–Dec'25
🔍 DNA replication & biotech #piMDA #WGA, bacterial genomics & defense
👉 rnrlab.github.io
#Postdoc #JdC2025
@iib.uam.es @uammedicina.bsky.social

Pollutants are also directly linked to some cancers, it really is a 360 degree health emergency

The role of ecoimmunology in tackling the emerging threats of climate change and the exposome Nature Immunology - Climate change creates a multitude of challenges over the human life-course, influencing our exposomes and shaping immune function — requiring researchers to consider...

Climate change poses multiple challenges to our health. Our new article coauthored with @kathelse.bsky.social considers the rise in infections and pollution combines with the impact of climate change on our immune system and what we need to do to better understand this 🧪 🧵#EcoImmunology

Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia - Nature Metabolism Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in mice.

www.linkedin.com/redir/redire...

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

www.nature.com/articles/s42...

Congrats @jourdainlab.bsky.social & team!!

🔐 Account Security Thread 🔐
We're seeing an increased number of phishing and social engineering attempts targeting Bluesky users. While we're working hard to protect you, here are essential steps YOU can take to secure your account and stay safe. 1/10
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Infographic

Interpreting liver blood test results can be challenging. How should clinicians interpret abnormal results?

New Education articles offers guidance and a visual summary
#BMJInfographic
www.bmj.com/content/391/...

Is AI making job recruitment less meritocratic? We're getting some v interesting research studies on this question now, and the news is... not good. @jburnmurdoch.ft.com & I dive in, in the latest edition of our newsletter The AI Shift www.ft.com/content/e5b7...

1/ New ‘fundamental’ study shows that neuronal migration depends on blood flow in the adult mammalian brain.
elifesciences.org/articles/995...

A tale of two distinct actin networks underlies the entire life cycle of focal adhesion Cell assembles focal adhesion (FA) to transmit the stress fiber (SF)-based actomyosin contraction onto the extracellular matrix (ECM) for mesenchymal migration, essential for many physiological proces...

Dong R, et al. A tale of two distinct actin networks underlies the entire life cycle of focal adhesion. bioRxiv posted 13 November 2025 doi:10.1101/2025.11.12.688129. www.biorxiv.org/content/10.1...

Data Scientist in Sutton | The Institute of Cancer Research View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 to £53,500 (Dependent on experience ) Reporting to: Professor Trevor Gra...

Calling cancer data scientists! 📊 💽 🧮
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...

2nd VHIO-BBVA Foundation Symposium on Cell-Based Therapies in Oncology DAY 2 YouTube video by Vall d'Hebron Institute of Oncology - VHIO

✨ Good morning from Barcelona!

We’re kicking off the second day of the 2nd VHIO –Fundacion @bbvaenespana.bsky.social Symposium on Cell-Based Therapies in Cancer.

Another round of innovation, science and brilliant minds ahead.

🎥 The event on YT: www.youtube.com/live/MlYp4S8...

#VHIOBBVASymposium

A cross-scale analysis for the determinants of bonding dynamics on the distributions of rolling velocities of cells in microvessels The interplay between subcellular adhesion dynamics and cellular-scale deformations under shear flow drives key physiological and pathological processes. Whereas both bond kinetics and fluid-cell…

Cells rolling in microvessels = like shopping carts with varying wheel grip. Yonggang Li et al. (2025) link molecular bond dynamics to how fast cells “roll” in blood flow. Tiny stickiness = big traffic effects!

Termination of the integrated stress response Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...

Termination of the integrated stress response | Science www.science.org/doi/10.1126/...