Rene Sugar

Autoantibodies against type I IFNs in patients with life-threatening COVID-19 In a large immunological and genomics study of COVID-19 patients, autoantibodies to type 1 interferons correlated with outcomes.

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

science.sciencemag.org/content/370/...

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 A large immunological and genomics study of COVID-19 patients reveals excess mutations in the type I IFN pathway.

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

pmc.ncbi.nlm.nih.gov/articles/PMC...

Autoantibodies against type I interferons correlate with low CD169/SIGLEC1 and severe non-viral infections in ER patients - PubMed Neutralizing autoantibodies against type I interferons are a risk factor for multiple severe viral diseases. The timely detection of these autoantibodies remains an unmet need. We hypothesized that paradoxically low expression of type I IFN-induced CD169/SIGLEC1 expression analyzed by flow cytometry …

Autoantibodies against type I interferons correlate with low CD169/SIGLEC1 and severe non-viral infections in ER patients

pubmed.ncbi.nlm.nih.gov/41329209/

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"This is a unique example of convergent evolution resulting in enhanced immune evasion of important pathogens via utilization of a “superevasion site.”"

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Binding via this site not only mimics the glycosaminoglycans of the host cells, but also enhances function of FH on the microbial surfaces via the novel mechanism of tripartite complex formation."

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"In this study we reveal that seven microbes representing different phyla utilize a common binding site on the domain 20 of FH for complement evasion."

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Surprisingly, the microbial proteins enhanced binding of FH19-20 to C3b and down-regulation of complement activation."

"We show that this is caused by formation of a tripartite complex between the microbial protein, FH, and C3b."

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Binding of FH to the microbial proteins was inhibited with heparin showing that the common microbial binding site overlaps with the heparin site needed for efficient binding of FH to host cells."

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"We show that all studied microbes use the same binding region located on one side of domain 20."

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"and whole microbes (Haemophilus influenzae, Bordetella pertussis, Pseudomonas aeruginosa, Streptococcus pneumonia, Candida albicans, Borrelia burgdorferi, and Borrelia hermsii)."

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"We used a selection of FH19-20 point mutants to reveal the binding sites of several microbial proteins"

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Many pathogenic microbes protect themselves from complement by recruiting host FH."

"We analyzed how and why different microbes bind FH via domains 19–20 (FH19-20)."

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"FH binds simultaneously to host cell surface structures such as heparin or glycosaminoglycans via domain 20 and to the main complement opsonin C3b via domain 19."

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"It can attack all kinds of targets and is tightly controlled in plasma and on host cells by plasma complement regulator factor H (FH)."

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement."

Microbes Bind Complement Inhibitor Factor H via a Common Site To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in ...

Microbes Bind Complement Inhibitor Factor H via a Common Site #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...

Altered increase in STAT1 expression and phosphorylation in severe COVID‐19 Anomalous upregulation of STAT1 and IRF9 (key components of IFN signaling) in B and T cells and monocytes from patients with severe COVID-19, with absence of pSTAT1 upregulation upon IFN restimulatio....

Altered increase in STAT1 expression and phosphorylation in severe COVID-19

onlinelibrary.wiley.com/doi/10.1002/...

"Both Siglec-1 and STAT1 were lower among severely affected COVID-19 patients compared to mildly affected COVID-19 patients"

Type I and II Interferon Signature Quantitation in Monocytes by Flow Cytometry
T1A2MP

www.testmenu.com/nationwidech...

CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Activation of the type I interferon pathway rapidly increases the expression of CD169 on the surface of monocytes and macrophages."

CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against ...

CD169/SIGLEC1 is expressed on circulating monocytes in #COVID19 and expression levels are associated with disease severity #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...

Researchers praise ‘stunning’ results of new prostate cancer treatment Early trials of the drug VIR-5500 showed it shrinking tumours in some patients

I have this cancer in remission (nearly 20 years now). I'm convinced the only reason I'm still alive is because I was (for a neuro knock-on catastrophe) treated with immunoglobulin donated by strangers. Their antibodies taught mine, got me out of a wheelchair.

www.theguardian.com/society/2026...

The image shows a brain scan of a patient with multiple sclerosis on the left. On the right is an illustration of a hand wearing a red laboratory glove. The hand is holding three test tubes containing blue liquid in a rack.

New diagnostic markers for multiple sclerosis discovered in cerebrospinal fluid!

❕ Publication: www.sciencedirect.com/science/arti...
❕ Press release: www.biochem.mpg.de/new-diagnost...

@mannlab.bsky.social @cellpress.bsky.social @tum.de
#ms #CSF #diagnosticmarker #markerproteins

Treatment of HTLV-I-Associated Myelopathy / Tropical Spastic Paraparesis: Towards Rational Targeted Therapy An official website of the United States government

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Differentiating HAM/TSP from primary progressive MS is occasionally a diagnostic challenge, since the two are clinically indistinguishable and the mere presence of positive HTLV-I serology does not always lead to neurological disease."

Treatment of HTLV-I-Associated Myelopathy / Tropical Spastic Paraparesis: Towards Rational Targeted Therapy An official website of the United States government

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Some have reported higher prevalence of positive HTLV-I serology in patients with Sjogren syndrome, and the findings of some elements of Sjogren syndrome may not be mutually exclusive with the diagnosis of HAM/TSP."

Treatment of HTLV-I-Associated Myelopathy / Tropical Spastic Paraparesis: Towards Rational Targeted Therapy An official website of the United States government

Treatment of HTLV-I-Associated Myelopathy / Tropical Spastic Paraparesis: Towards Rational Targeted Therapy #HTLV1 #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...

LitCovid LitCovid is a curated literature hub for tracking up-to-date scientific information about the 2019 novel Coronavirus.

#LongCovid papers

Post-COVID conditions and sequelae

www.ncbi.nlm.nih.gov/research/cor...

Across Barriers: Blood–Brain and Gut Barrier Signaling in Psychiatric Disorders

pmc.ncbi.nlm.nih.gov/articles/PMC...

Matrix Dynamics and Microbiome Crosstalk: Matrix Metalloproteinases as Key Players in Disease and Therapy #MECFS #LongCovid

www.mdpi.com/1422-0067/26...

Dual roles of lactate and lactylation modification in the nervous system: neuroprotection and neuroinjury #MECFS #LongCovid

www.frontiersin.org/journals/agi...

The Bedside Cold Agglutinin Test is underused in outpatients with M. pneumoniae infections

A woman with dry cough and breathlessness

www.bmj.com/content/385/...

"The Bedside Cold Agglutinin Test is underused in outpatients with M. pneumoniae infections"

"Cold agglutinin titer is reported to be elevated in 50%-75% of patients with M. pneumoniae."