Rene Sugar

Viral Diversity Influences T Cell Responses to Enteric Human Adenoviruses F40 and F41 Background Human enteric species F adenoviruses are a leading cause of diarrhoea-associated paediatric morbidity and mortality worldwide. The cellular immune response (antigen-specific cytotoxic T cel...

I'm pleased to share a preprint today, paper 2/3 of a trilogy (you'll have to wait for the Return of the Jedi). In 2021-22, lots of countries saw unprecedented transmission of enteric adenovirus F41 in children. There were lots of hypotheses about what caused this.
www.biorxiv.org/content/10.1...

ZNFX1: a multifunctional modulator of the innate immune response #MECFS #LongCovid

bsky.app/profile/rene...

ZNFX1: a multifunctional modulator of the innate immune response Recent research has identified ZNFX1 as a critical modulator of the innate immune response. Individuals with loss of function mutations in ZNFX1 have chronic inflammation and increased susceptibility ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"These disease manifestations often start early in childhood and exhibit a high mortality rate."

"Recently, ZNFX1 deficiency has also been associated with increased susceptibility to mycobacterial diseases."

ZNFX1: a multifunctional modulator of the innate immune response Recent research has identified ZNFX1 as a critical modulator of the innate immune response. Individuals with loss of function mutations in ZNFX1 have chronic inflammation and increased susceptibility ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Such patients have predisposition to viral infections and severe multisystem inflammatory diseases including cytopenia, hepatitis, seizures, renal and lung disease."

ZNFX1: a multifunctional modulator of the innate immune response Recent research has identified ZNFX1 as a critical modulator of the innate immune response. Individuals with loss of function mutations in ZNFX1 have chronic inflammation and increased susceptibility ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"To date, all patients have carried either homozygous or trans compound heterozygous pathogenic variants of the ZNFX1 gene, leading to a loss of ZNFX1 expression."

"Individuals with ZNFX1 deficiency suffer from altered immune regulation."

ZNFX1: a multifunctional modulator of the innate immune response Recent research has identified ZNFX1 as a critical modulator of the innate immune response. Individuals with loss of function mutations in ZNFX1 have chronic inflammation and increased susceptibility ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"In recent years, an understudied protein known as NFX-1 type zinc finger-containing protein 1 ( #ZNFX1) has been implicated as an important immunomodulator of the innate immune system."

"ZNFX1 deficiency is an autosomal recessive disorder."

ZNFX1: a multifunctional modulator of the innate immune response Recent research has identified ZNFX1 as a critical modulator of the innate immune response. Individuals with loss of function mutations in ZNFX1 have chronic inflammation and increased susceptibility ...

ZNFX1: a multifunctional modulator of the innate immune response #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...

Key Functions Summary: (cont)

DNA Repair & Cell Cycle: MMS22L, CSE1L, DDX27

Cell Adhesion & Signaling: PCDH8, VSIG10, ANKRD45, OLFM4

Key Functions Summary:

Mitochondrial Function: DARS2, PRDX6, SLC17A1, CA10, KLHL20, FBXL4

Immune System: BTN2A2, BTN3A3, TNFSF4, TRIM38, SERPINC1, PTGIS

Cellular Metabolism: ARFGEF2, RABGAP1L, B4GALT5, GPR52, PEBP1, HFE

Gene Expression Regulation: RC3H1, SUDS3, HMGN4, ZNF322, ZBTB97, STAU1

We're Losing The Internet. But It's Not Too Late Governments are conducting a sneak attack on the internet and we’re about to lose what we didn’t even know we had.

The real goal of internet age verification is to de-anonymize the internet so that your data - and your opinions - can more easily be collected and sold to whatever corporations (or governments) are interested in them.
www.donotpanic.news/p/were-losin...

The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...

Initial findings from the @decodemestudy.bsky.social genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome #MECFS

www.research.ed.ac.uk/en/publicati...

eg.

- FBXL4 (MITOCHONDRIAL DNA DEPLETION SYNDROME 13)
- ZNFX1 (IMMUNODEFICIENCY 91 AND HYPERINFLAMMATION)

eg. FBXL4 mutations seen in DecodeME study can cause heart problems and others.

FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion Syndrome

www.ncbi.nlm.nih.gov/books/NBK425...

FBXL4 mutations seen in NHS cases:

panelapp.genomicsengland.co.uk/panels/entit...

bsky.app/profile/deco...

Post on X from Daniel Missailidis reads: "One of the genes is FBXL4, critical for mitophagy. This is the process by which our mitochondria are recycled, whether due to damage or other reasons. Mitophagy’s been slept on in ME/CFS research and could explain a lot of what’s going wrong at a cell level. Let’s get to work.🫶" Shows a DecodeME slide with the words: "DecodeME the results: Eight genetic signals have been identified. As DNA doesn't change with ME/CFS onset, these findings reflect causes rather than effects of ME/CFS."

From @danielmissailidis.bsky.social on X:

"One of the genes is FBXL4, critical for mitophagy. This is the process by which our mitochondria are recycled, whether due to damage or other reasons.
Mitophagy’s been slept on in ME/CFS research and could explain a lot of what’s going wrong..." #decodeME

Novel Organism Verification and Analysis (NOVA) study: identification of 35 clinical isolates representing potentially novel bacterial taxa using a pipeline based on whole genome sequencing - BMC Micr... Background Reliable species identification of cultured isolates is essential in clinical bacteriology. We established a new study algorithm named NOVA – Novel Organism Verification and Analysis to sys...

Novel Organism Verification and Analysis (NOVA) study: identification of 35 clinical isolates representing potentially novel bacterial taxa using a pipeline based on whole genome sequencing

bmcmicrobiol.biomedcentral.com/articles/10....

Gotcha! Whole-genome sequencing discovers seven unidentified bacteria of clinical relevance 35 new bacterial strains have been identified by whole-genome sequencing, seven of which are clinically relevant.

www.biotechniques.com/computationa...

"An ongoing research project at the University of Basel (Switzerland) has identified more than 30 new strains of bacteria, collected from patients at the University Hospital Basel, using a whole-genome sequencing approach."

Gotcha! Whole-genome sequencing discovers seven unidentified bacteria of clinical relevance 35 new bacterial strains have been identified by whole-genome sequencing, seven of which are clinically relevant.

Gotcha! Whole-genome sequencing discovers seven unidentified bacteria of clinical relevance #MECFS #LongCovid

www.biotechniques.com/computationa...

Graphic 1 of 4. DecodeME: The Results graphic. At the top in bold lettering, it says ‘Main Findings’. Beneath this it says ‘Your genes contribute to your chances of developing ME/CFS. Other key findings are on the following slides.

Graphic 2 of 4. DecodeME: The Results graphic. The slide says ‘People with an ME/CFS diagnosis have significant genetic differences in their DNA compared to the general population’. Beneath this is an image of a DNA helix and a magnifying glass.

Graphic 3 of 4. DecodeME: The Results graphic. The slide says ‘These lie in many places across the genome, and do not impact just one gene’. Beneath this is an image of a DNA helix and graphs.

Graphic 4 of 4. DecodeME: The Results graphic. The slide says ‘Eight genetic signals have been identified. As DNA doesn’t change with ME/CFS onset, these findings reflect causes rather than effects of ME/CFS’. Beneath this is a blue magnifying glass with a DNA helix.

(1/2) Key genetic differences found in people with ME/CFS > Swipe to find out more.

These findings reflect the lived experience of thousands of #pwME.

Thanks to all our participants & supporters who made this possible!

Read a summary of our results: shorturl.at/pgsjk

Lithium deficiency and the onset of Alzheimer’s disease - Nature Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.

New @nature.com
The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depletion impedes amyloid clearance, and repletion in humans could be achieved with low doses
nature.com/articles/s41...

Multiple Sclerosis and #MitoQ: A Personal Perspective #EBV #MECFS #LongCovid

bsky.app/profile/rene...

MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation Mitochondrial perturbations are the major culprit of the inflammatory response during the initial phase of cerebral ischemia. The present study explor…

www.sciencedirect.com/science/arti...

"Reversal of hippocampal function by MitoQ was accompanied by improved cognitive function and hippocampal morphological aberrations."

MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation Mitochondrial perturbations are the major culprit of the inflammatory response during the initial phase of cerebral ischemia. The present study explor…

www.sciencedirect.com/science/arti...

"In addition, MitoQ alleviated the inflammatory mediators, TNF-α, IL-18, and IL-1β and dampened GFAB immunoexpression along with downregulation of cleaved caspase-3 expression."

MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation Mitochondrial perturbations are the major culprit of the inflammatory response during the initial phase of cerebral ischemia. The present study explor…

www.sciencedirect.com/science/arti...

"Pretreatment with MitoQ markedly potentiated SIRT6, modulated mitochondrial oxidative status and restored mitochondrial biogenesis and function."

MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation Mitochondrial perturbations are the major culprit of the inflammatory response during the initial phase of cerebral ischemia. The present study explor…

www.sciencedirect.com/science/arti...

"- Alleviation of hippocampal mitochondrial aberration, inflammation, and apoptosis by MitoQ might be associated with restoring SIRT6 levels"

MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation Mitochondrial perturbations are the major culprit of the inflammatory response during the initial phase of cerebral ischemia. The present study explor…

www.sciencedirect.com/science/arti...

"- Cerebral I/R associated with various pathophysiological consequences including apoptosis, inflammation, and mitochondrial dysfunction
- MitoQ exhibited remarkable neuroprotection in cerebral I/R-induced hippocampal injury in rats."

MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation Mitochondrial perturbations are the major culprit of the inflammatory response during the initial phase of cerebral ischemia. The present study explor…

MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation #MECFS #LongCovid

www.sciencedirect.com/science/arti...

Bacteria-based cancer therapy achieves tumor eradication without immune cells A joint research team led by Professor Eijiro Miyako of the Japan Advanced Institute of Science and Technology (JAIST), in collaboration with Daiichi Sankyo Co., Ltd. and University of Tsukuba, has de...

Bacteria-based cancer therapy achieves tumor eradication without immune cells

flip.it/XJYSqh

Dark blue background with image of DNA helix. At the top of the DecodeME ‘the results’ logo. Two spotlights shine on a speech bubble that says ‘Initial DNA results’. To the right of this is an image of a research paper. At the bottom of the graphic it says ‘Wednesday 7pm BST’.

The initial DNA results from DecodeME are coming this week! We will release them on our website on Wednesday 6th August at 7pm (approx).

We're letting you know the timing in advance so you can pace beforehand.

Thank you to our participants & supporters.

Now online in Cancer Discovery @aacrjournals.bsky.social: Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling - by Hsi-wen Yeh, Nicole Del Gaudio, Kivanç Birsoy, and colleagues doi.org/10.1158/2159... @rockefelleruniv.bsky.social

CARv3-TEAM-E T Cells in Glioblastoma

clinicaltrials.gov/study/NCT056...