Anush Chiappino-Pepe

Excited to release BoltzGen which brings SOTA folding performance to binder design! The best part of this project is collaborating with a broad network of leading wetlabs that test BoltzGen at an unprecedented scale, showing success on many novel targets and pushing the model to its limits!

Empathy and kindness are becoming rather rare traits these days. There is nothing more important than treating each other like the finite mortal short-lived nociceptive beings we are. A life lived in apathy feels so much shorter and far too cold.

Try to love more while you live.

Congratulations, Johannes!!! So happy to see your amazing work out! 🎉

(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!

Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵

Controlled colonization of the human gut with a genetically engineered microbial therapeutic Precision microbiome programming for therapeutic applications is limited by challenges in achieving reproducible colonic colonization. Previously, we created an exclusive niche that we used to engraft...

Important work for engineered microbial therapeutics @science.org

"Controlled colonization of the human gut with a genetically engineered microbial therapeutic"

"a therapeutic candidate that reduced hyperoxaluria, a cause of kidney stones"

www.science.org/doi/10.1126/...

It is the child of an ant and a beetle!

Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind

This is wild!
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Amazing! Congratulations to Kristala! I hope you are all enjoying the meeting.

We're one step closer to recreating the brain’s immune system in a dish thanks to researchers at @wyssinstitute.bsky.social & @harvardmed.bsky.social!🧫

Dr. George Church's (@geochurch.bsky.social) lab created #microglia from #iPSCs that resemble microglia from humans: bit.ly/4jPxYTJ

At Columbia, dismay among chemical scientists Some have already lost grants, while others fear for students and future funding

I was among a few people at Columbia interviewed by Chemical and Engineering News (this is one of my faculty colleagues on the cover):
cen.acs.org/policy/resea...

The Importance of Science The United States has been the preeminent force in the world economy for the past 50 years because it has been the leader in technology innovation. The abrupt changes in government funding for scienti...

The US has been a preeminent force in the global economy for the past 50 years, mainly due to its leadership in technological innovation. The abrupt changes in government funding for scientific research can stop this innovation engine. Hear more from our community about the importance of science.

In similar situations, my son later says: do you want a hug? 😂❤️

Directed evolution of aminoacyl-tRNA synthetases through in vivo hypermutation - Nature Communications Genetic code expansion (GCE) enables the incorporation of new amino acids into proteins. Here, authors demonstrate the rapid OrthoRep-driven evolution of aminoacyl-tRNA synthetases for GCE, increasing...

Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to Yuichi Furuhata, a true master bioengineer, on leading this excellent work! www.nature.com/articles/s41...

A lot is happening, but science keeps me excited and energized. This is how much we scientists care about discovery and making a positive impact on society. Thank you to everyone who supports us.

Harvard today, your institution tomorrow.

It's all part of the Project 2025 plan to destroy high education in America.

All leading US universities depend on federal funding and tuition dollars from international students. They severely curtailed the former. Now they're eliminating the latter.

A photograph of Louis Bamberger, seated on the right, wearing a mustache and bowler hat, and his sister Caroline Bamberger Fuld, standing on the left, wearing a fur hat and shawl

Let's talk about these two department store owners: brother and sister Louis Bamberger and Caroline Bamberger Fuld. From Newark, New Jersey.

They are random people, basically. But in the late 1920s, with fascism taking over Europe, they made a choice that profoundly changed the world: 🧵

I am very sorry Prof Baym :(

Bioremediation of complex organic pollutants by engineered Vibrio natriegens - Nature A synthetic biology approach was used to engineer Vibrio natriegens into a strain capable of bioremediating complex organic pollutants in saline wastewater and soils, thereby addressing notable threat...

Vibrio natriegens has been engineered for bioremediation of complex organic pollutants - biphenyl, phenol, naphthalene, dibenzofuran and toluene - in saline wastewater and soils

🧪

www.nature.com/articles/s41...

😢

Elizabeth Hann on Using Microbes to Save the Earth The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and be...

Elizabeth Hann imagines a future where food production is more sustainable. She's developing microbes that produce commodities more sustainably. Learn more about Elizabeth & her work in this month’s #HOWyss.

Congratulations!! Very nice!

Zero-shot design of drug-binding proteins via neural selection-expansion Computational design of molecular recognition remains challenging despite advances in deep learning. The design of proteins that bind to small molecules has been particularly difficult because it requ...

Super excited to share a new preprint from our lab on design of small-molecule binding proteins using neural networks! The paper has a bit of everything. A new graph neural network, new design algorithms, and experimental validation. www.biorxiv.org/content/10.1...
🧵🧪

I am a bit traumatized. I first read „mass deportation“ 🫣

i'm just a senior postdoc, standing in front of a career that i have worked really hard for, asking higher education in the united states to not completely implode in front of my eyes before i even get a chance to say the words 'my lab studies'

Huge opportunity for postdocs gearing up for an academic job search, hosted by @stanford-chemh.bsky.social @berkeleymcb.bsky.social and UCSF!

NIH cancels its first and largest study centered on women The Women’s Health Initiative has produced numerous influential findings

This is very sad and wasteful. A lot of the value comes from longitudinal data. Stopping early wastes all of the startup costs. NIH cancels its first and largest study centered on women | Science | AAAS www.science.org/content/arti...

YouTube video by Association of American Universities Facilities and Administrative (F&A) Costs Explainer

AAU updates their excellent explainer about indirect costs to cover the current attacks...

www.youtube.com/watch?v=NtqK...

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Our Health ROI Explore how your tax dollars fund life‑saving medical research.

Ever wonder how many lives have been saved by NIH-funded research - including your own? Enter any medical condition and instantly see how your tax dollars transformed science into survival.

www.ourhealthroi.com

PlasmidScope: a comprehensive plasmid database with rich annotations and online analytical tools Abstract. Plasmids are extrachromosomal genetic molecules that replicate independent of chromosomes in bacteria, archaea, and eukaryotic organisms. They co

A huge, new resource for plasmid research - PlasmidScope is a database of 852,000 #plasmid sequences with a rich set of annotations, automated online analysis and interactive visualisation academic.oup.com/nar/article/...