Francesco Strati

Fungal cues, fibrotic consequences: Commensal sensing by alveolar macrophages promotes pulmonary fibrosis In a recent issue of Immunity, Qiu et al. uncover a pivotal role for commensal fungi in promoting lung fibrosis, showing that their interaction with alveolar macrophages triggers a profibrotic transcr...

Fungal cues, fibrotic consequences:

Highlight of @cp-immunity.bsky.social work uncovering role for commensal fungi in lung fibrosis, showing that their interaction w/alveolar macrophages triggers profibrotic transcriptional program through Dectin-1-Raf1 signaling axis
www.cell.com/cell-host-mi...

This is so cool, congrats @lozanzi.bsky.social and team! Important implications for infection and IBD

Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis @natimmunol.nature.com
www.nature.com/articles/s41...

📥 You have only until 24 June to submit your abstract for 'The human microbiome'❗

🔬💊 Explore cutting-edge breakthroughs in #microbiome research, from methodological innovations to integrative approaches and personalised therapeutics. Join #EESMicrobiome 🦠🔍

➡️ https://s.embl.org/ees25-08-bl

It was a great experience that gave me both feedback and confidence to move forward in my journey.

Don’t miss the chance to apply next year, this program is a true gem!

Hi Bluesky folks and mucosal immunology lovers!
I just want to shout out loud how fantastic the SMI’s @societymucosalimm.bsky.social Mentoring Program is!

I had the chance to present my science at KI and exchange ideas about career paths and research with the legendary @ejvillablanca.bsky.social

Postdoctoral position in Computational Biology open !

Our Lab is trying to understand the molecular and cellular mechanisms involved in establishing intestinal immune homeostasis and how a breakdown of these mechanisms may lead to diseases

More info 👇 :

lnkd.in/dQZq55nv

lnkd.in/d6sbw59P

Foxp3 confers long-term efficacy of CAR-T cells via metabolic reprogramming
www.cell.com/cell-metabol...

MESA
Ecology-inspired spatial analysis👹
Spatial+single-cell multiomic integration

Multiscale/Global/Local Diversity Index
Diversity Proximity Index

Cell ~Diversity ~Hot/Cold spot maps

Hot spot-focused spatial analysis⏫biological resolution

@natgenet.nature.com 2025
www.nature.com/articles/s41...

Diet outperforms microbial transplant to drive microbiome recovery in mice - Nature Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic interactions that occur only with specific dietary interventions.

Nature research paper: Diet outperforms microbial transplant to drive microbiome recovery in mice.

https://go.nature.com/42R2PJ5

A metabolite secreted by an intestinal fungus blunts metabolic disease @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

Cytotoxic cells, especially NK cells, have a particular dependence on glycosphingolipid synthesis to survive and maintain cellular function @cellcellpress.bsky.social www.cell.com/cell/fulltex...

Shaping the future of inflammatory bowel disease: a global research agenda for better management and public health response Nature Reviews Gastroenterology & Hepatology, Published online: 22 April 2025; doi:10.1038/s41575-025-01063-xInflammatory bowel disease (IBD) is an immune-mediated disease with substantial burden worldwide. In this Consensus Statement, a global multidisciplinary group of experts identify key priorities and recommendations to raise awareness and advance IBD care and research.

ICYMI: New online! Shaping the future of inflammatory bowel disease: a global research agenda for better management and public health response

The microbiota shapes the life trajectory of mucosal-associated invariant T cells Mucosal-associated invariant T (MAIT) cells are innate-like T cells predominantly located in barrier tissues such as the lung, liver, skin, and colon. These cells recognize metabolites derived from the riboflavin biosynthetic pathway, which can rapidly traverse epithelial barriers and be presented during MAIT cell differentiation in the thymus and maturation in peripheral tissues. Furthermore, microbial metabolites significantly influence MAIT cell functions in various conditions, including cancer. This review summarizes how the microbiota shapes the life trajectory of MAIT cells and their antitumor reactivity. Additionally, we discuss the therapeutic implications of manipulating the microbiota as a ‘bug-drug’ strategy to enhance MAIT cell antitumor immunity, particularly in mucosal cancers, while emphasizing challenges and future directions for integrating microbiota considerations into MAIT cell-based therapies.

The microbiota shapes the life trajectory of mucosal-associated invariant T cells

Microbial metabolite drives ageing-related clonal hematopoiesis via ALPK1 @nature.com
www.nature.com/articles/s41...
Congrats Dan Starczynowski @cincyresearch.bsky.social

Tumour interstitial fluid-enriched phosphoethanolamine suppresses T cell function - Nature Cell Biology Wang, Wilfahrt and colleagues show that phosphoethanolamine, a phospholipid intermediate, is enriched in tumour interstitial fluid and induces T cell dysfunction, in part by depleting diacylglycerol a...

Tumor interstitial fluid is enriched with metabolites like phosphoethanolamine that suppresses T cell function
@naturecellbiology.bsky.social @delgoffelab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

A host-pathogen metabolic synchrony that facilitates disease tolerance @natcomms.nature.com @sebariquelme.bsky.social
www.nature.com/articles/s41...

The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses @cp-cellreports.bsky.social
www.cell.com/cell-reports...

OPEN CALL for PhD positions in our lab through the semm_it program:

1️⃣ Microbiome signatures of early on-set colorectal cancer
2️⃣ High-resolution computational metagenomics for the study of human microbiome transmission

More info: www.semm.it/education/op...

Apply by June 9!

Multi-cohort analysis reveals colorectal cancer tumor location-associated fecal microbiota and their clinical impact Lin et al. reveal fecal microbial changes in proximal and distal colorectal cancer (CRC) and identify microbes associated with each tumor location. This study also demonstrates the diagnostic potentia...

Featured Article: Microbiota changes with CRC tumor location.
Fecal microbial changes in proximal vs distal CRC w/specific microbes linked to tumor location. Multi-cohort analysis demonstrates diagnostic potential of location-specific fecal bacteria in CRC
www.cell.com/cell-host-mi...

New @science.org
Discovery of a mechanism for cancer cachexia (components of severe apathy, depression) explained by a neuroimmune circuit
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

Dietary lipid overload creates a suppressive environment that impedes the antiviral functions of NK cells www.cell.com/iscience/ful...

The emerging landscape of engineered bacteria cancer therapies - Nature Biotechnology Our ability to use engineered bacteria for cancer therapy is rapidly expanding. A survey of preclinical, clinical and commercial efforts provides an overview of the state of the field, revealing trend...

Check out the state of the field of engineered bacteria for cancer therapy in this Comment in @naturebiotech.bsky.social www.nature.com/articles/s41...

Bifidobacteria support optimal infant vaccine responses - Nature Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probio...

Delighted our study (7+ years in the making) is out today in Nature. In a nutshell, 48 hours of antibiotics in week 1 led to impaired vaccine responses up to 15 months later in infants. We show (in-vivo) a probiotic can fix it #microbiome #science #immunology
www.nature.com/articles/s41...

Tumor cell heterogeneity drives spatial organization of the intratumoral immune response @jem.org
rupress.org/jem/article/...
@mreeves34.bsky.social

Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method - Nature Biotechnology Off-the-shelf CAR-NKT cells for cancer immunotherapy are advanced toward clinical translation.

Off-the-shelf CAR-NKT cells for cancer immunotherapy are advanced toward clinical translation go.nature.com/4akbFkj
rdcu.be/efeUJ

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social

In this N&V, B. Attema and F. Kuipers @unigroningen.bsky.social discuss the study by Schoonjans & colleagues that reveals the important role of secondary #BileAcid signaling in colon #MucosalHealing after injury.

👉 doi.org/10.1038/s443...
👉Related article: doi.org/10.1038/s443...

Spatial profiling show ILCs can contribute to IL-10 production during intestinal inflammation. These ILCs may also recruit interactions with macrophages by producing CCL26, the ligand for CX3CR1: www.mucosalimmunology.org/article/S193...