Mohanad Al-Obaidi

Performance of Diagnostic Algorithms in Patients With Invasive Pulmonary Aspergillosis Invasive pulmonary aspergillosis (IPA), once limited to immunocompromised patients, is now a severe complication in critically ill ICU patients without classic risk factors.

Performance of Diagnostic Algorithms in Patients With Invasive Pulmonary Aspergillosis

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#idboardreview 60 M idiopathic pulmonary fibrosis s/p lung transplant 2wks ago( on antithymocyte globulin, tacro, azathioprine, pred) now w/ pleuritic chest pain, dyspnea. +emypema s/p drainage: pinpoint colonies. diagnosis? #medEd #idmedEd #idsky

Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine.

If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.

"Cocoa farmer David Kebu Jnr holding fermenting cocoa beans." "Photo taken by Irene Scott for AusAID. (13/2529)"

There are two fungi naturally found on seed pods:
1. Picha kudriavzevii (a unicellular yeast)
2. Geotrichum candidum (multicellular fungus)

Also present are lactic acid & acetic acid bacteria. Between them all they acidify & break down as much as 90% of the bitter polyphenols.

#Medsky🧪 #IDsky #Episky #neurosky #immunosky #publichealth @bmj.com Studies have shown that inflammatory alterations in the 🧠 caused by ( #Herpessimplexvirus 1 ) HSV infection are pivotal in #Alzheimersdisease development.

bmjopen.bmj.com/content/15/5...

journals.sagepub.com/doi/pdf/10.1...

Congratulations!

Figure. Hospital-Level Correlations Between Mortality Outcomes Among Patients With Sepsis

In this all-payer, multihospital cohort of patients with community-onset sepsis, the proportion of hospitalizations ending in death or hospice discharge was similar to 30-day mortality and substantially higher than in-hospital mortality alone. https://ja.ma/4kEpu2R

Candida vulturna, the Next Fungal Menace? A Narrative Review Introduction The yeast Candida vulturna is a member of the Candida haemulonii species complex, like its close relative Candida auris. Members of this species complex, including C. vulturna, often di...

Candida vulturna (member of Candida haemulonii species complex)can be misidentified with reduced azole and ampho susceptibilities. #MedMyco #IDSky

This ancient pathogen became deadlier when humans started wearing wool Ancient genomes reveal that a bacterial fever jumped from human-borne ticks to lice around the time wool textiles became common.

I never thought about wool as a possible route of infection.

www.nature.com/articles/d41...

#IDSky #MedSky

MSGERC is seeking fungal infection cases (common or unusual) for Case of the Month.

Do you have a case? Submit it to be featured on DrFungus.org!

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People
#IDSky #MedMyco #histoplasma

New! #Candidaauris meeting in Miami… join us #IDSky med.miami.edu/departments/...

#MedSky #IDSky #MedMyco

The Fourth International Consensus Guidelines on the... : Transplantation An abstract is unavailable.

Excited to share the fourth version of the international consensus guidelines on CMV management after a solid organ transplant, on behalf of all 50 contributors and @ttsorg.bsky.social journals.lww.com/transplantjo...

Longitudinal Assessment of the Effect of Invasive Fungal Infections on Transplant Success in Kidney Transplant Recipients Invasive fungal infections (IFIs) significantly impact morbidity and mortality in kidney transplant recipients (KTR), but their effect on allograft fu…

www.sciencedirect.com/science/arti...

#IDSKy #MedMyco #TxID

New post on gepotidacin (pronounced "JEP-oh-TIE-dah-SIN"), a new antibiotic for uncomplicated UTIs with a brand name that sounds like it should be nesting in the Costa Rican rainforest.
(I kind of went off the rails on this one.) #IDSky blogs.jwatch.org/hiv-id-obser...

Deadly fungi are becoming drug-resistant. A new compound could beat them A drug candidate with a new mechanism of action shows promise against several drug-resistant infections in mice

Another bit of hopeful news, from @kakape.bsky.social: www.science.org/content/arti...

Purified T cell transplant lowers risk of immune reaction for blood cancer patients, study shows A T-cell therapy developed by Orca Bio, a private biotech company, significantly reduced the risk of a debilitating immune reaction in patients with several types of blood cancer.

#TxID #MedSky
“In the study, which enrolled 187 patients with four different types of leukemia, the T cell therapy called Orca-T reduced the risk of chronic graft versus host disease (GVHD) by 74% compared to a conventional matched-donor, or allogeneic, stem-cell”
www.statnews.com/2025/03/17/o...

🔍 108 Coccidioides peptides identified for VF diagnosis. They re-activated CD4+ T-cells in infected individuals vs. controls, aiding in diagnostic assay development. 🦠💉

#idsky

Effects of cancer therapy on AMR

Cisplatin➡️cross-resistance to FQ (target bacterial DNA)

Methotrexate➡️dihydrofolate reductase mutations➡️co-select for β-lactams/AG/fosfo resistance

Anthracyclines➡️efflux pump expression

Etoposide➡️oxidative stress➡️gyrA mutations

doi.org/10.1016/j.la...

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The 2024-2025 COVID-19 Vaccine Show Limited Efficacy in Adults The interim results demonstrated a slightly better vaccine effectiveness in individuals who are immunocompetent vs immunocompromised individuals.

The interim results demonstrated a slightly better vaccine effectiveness in individuals who are immunocompetent vs immunocompromised individuals. #IDsky #Medsky

msgerc.wildapricot.org/event-6071071

Have you heard about Valley Fever occurring after/during the recent California fires? Wondering about how climate change might relate to Cocci? @msgerc.bsky.social has two experts ready to discuss in this FREE webinar. March 12 - will be interesting and useful!

Not sure why a link attached to my response. Please ignore the link.

Hello Pascalis, very interesting but unfortunately most places don’t have species/subspecies identification. Do you have molecular methods to identify Aspergillus species?

YouTube video by JAMA Network Valley fever, aka coccidioidomycosis, may be on the rise

🎥 Valley fever, aka coccidioidomycosis, may be on the rise.

Discover how climate change is raising the risk of coccidioidomycosis and why it's crucial for clinicians, patients, and health systems to be well-informed for better patient care.

➡️ ja.ma/3XjVYGl

#MedSky

If you know anything about #Texas it should be that a case of #Measles at Bucee’s is going to be bad…

NIH funding cuts could have ‘devastating impact’ on medical advancements, Chicago researchers say The National Institutes of Health under President Donald Trump announced this month that it was cutting payments covering overhead costs for research institutions that receive its grants.

Freezing out the NIH's funding means freezing out American innovation.

Research into curing cancer, Alzheimer's, and Parkinson's all delayed.

And ultimately it won't just cost us advancements in life-saving research, it will cost us lives.

#IDSky #InfectiousDiseases

Images in Clinical Medicine Pleural Paragonimiasis Panel A: A chest radiograph obtained during a routine assessment at an immigration clinic Panel B: A small number of parasite eggs seen in the pleural fluid (hematoxylin and eosin staining)

An asymptomatic 17-year-old boy who had emigrated from El Salvador was found to have a pleural effusion on a chest radiograph. A small number of parasite eggs were seen in the pleural fluid. Full case details from @stanfordmedicine.bsky.social: nej.md/3CGzRTg

#MedSky #PulmSky #IDSky