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Kelly Nguyen

@kellythd-nguyen.bsky.social

Group Leader @MRC_LMB /Structural Biologist/Biochemist. Amateur baker in free time #RNAworld #spliceosome #telomerase #telomeres #cryoEM #Xraycrystallography

955 Followers  |  466 Following  |  55 Posts  |  Joined: 23.11.2024
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Posts by Kelly Nguyen (@kellythd-nguyen.bsky.social)

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RNA Splicing Lab - JOIN US Are you interested in investigating basic mechanisms in splicing regulation and gene expression? Our research group was launched in September 2024 and is hosted at the Institute of Molecular Infection...

We have an open position for a #PhD student (last week to apply!) & a lab technician/TA. For more information see: www.beuschlab.org/join-us
Interested in understanding post-transcriptional regulation and how #RNA #splicing decisions are made? Then take a look or share with people who might be! πŸ§ͺ🧫

02.03.2026 15:44 β€” πŸ‘ 12    πŸ” 12    πŸ’¬ 0    πŸ“Œ 0
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Fantastic news! πŸ™Œ The Perutz is excited to welcome Danny Nedialkova as a new group leader starting this April! πŸŽ‰ She will strengthen the institute's research on the fundamental mechanisms that shape cellular physiology and disease ➑️ www.maxperutzlabs.ac.at/research/res...

02.03.2026 14:27 β€” πŸ‘ 57    πŸ” 11    πŸ’¬ 1    πŸ“Œ 4

Exciting opportunity to work with an amazing scientist at the cutting edge of DNA repair and telomere biology.

02.03.2026 19:35 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Thank you Noe!

28.02.2026 18:37 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Laboratory Technician (Ding Group) | John Innes Centre An exciting opportunity has arisen for a Laboratory Technician to join the Cell & Developmental Biology Department, to support the cutting-edge science of the John Innes Centre.

VACANCY - We’re looking for a Laboratory Technician to join the @yiliangding.bsky.social group, investigating the role of #RNA structure in the post-transcriptional regulation of gene expression.

www.jic.ac.uk/vacancies/la...

Closing date - 17 March
Contract - 36 months, Full-time

25.02.2026 07:37 β€” πŸ‘ 8    πŸ” 9    πŸ’¬ 0    πŸ“Œ 0

I am so grateful to the Blavatnik Family Foundation and the New York Academy of Sciences for this honor. Can’t wait to be back to the lab and celebrate with lab members on this special recognition of their hard work.

25.02.2026 19:58 β€” πŸ‘ 81    πŸ” 11    πŸ’¬ 5    πŸ“Œ 2
Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.

Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme?
Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues.
Apply by 16 MAR
www.nature.com/naturecareer...

24.02.2026 09:45 β€” πŸ‘ 36    πŸ” 48    πŸ’¬ 0    πŸ“Œ 2
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. πŸ₯³

mrc.tal.net/vx/mobile-0/...

16.02.2026 12:09 β€” πŸ‘ 83    πŸ” 102    πŸ’¬ 1    πŸ“Œ 2
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A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
1/n

13.02.2026 11:42 β€” πŸ‘ 497    πŸ” 209    πŸ’¬ 10    πŸ“Œ 28

Congratulations Brenda! You are yourself an RNA hero for me and many others.

15.02.2026 03:27 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Postdoc Research Group Schur The Schur lab at the Institute of Science and Technology Austria (ISTA) has an open postdoc position for a highly motivated candidate to be part of our ERC-funded project ActinID. Our Group ...

Open Postdoc position in our lab!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.

ista.ac.at/en/job/postd...

Please share and feel free to reach out if there are questions!

13.02.2026 15:50 β€” πŸ‘ 32    πŸ” 19    πŸ’¬ 1    πŸ“Œ 2
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Antiparallel stacking of Csu pili drives Acinetobacter baumannii 3D biofilm assembly - PubMed Many Gram-negative nosocomial pathogens rely on adhesive filaments, known as archaic chaperone-usher pili, to establish stress- and drug-resistant, multi-layered biofilms. Here, we uncover the mechanism by which these pili build three-dimensional (3D) biofilm architectures. In situ analyses of Acine …

A. baumannii is one of the most notorious multidrug-resistant pathogens, capable of forming drug-tolerant biofilms that make infections exceptionally difficult to treat. But how are these complex microbial fortresses built? Just published in Nat Comms. pubmed.ncbi.nlm.nih.gov/41654547/

12.02.2026 13:27 β€” πŸ‘ 19    πŸ” 5    πŸ’¬ 1    πŸ“Œ 2
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Stories from the scientist who changed how we visualize proteins - Nature Reviews Chemistry Ahead of her 85th birthday, Jane Richardson, Professor of Biochemistry at Duke University, discussed her life in science from making her own telescope to developing the ribbon diagrams for the 3D stru...

Stories from #WomenInScience who changed how we visualize #proteins: Ahead of her 85th birthday, Jane Richardson (Duke Univ, @biophysicalsoc.bsky.social president 2012-13) discussed her life from making a telescope to developing ribbon diagrams for 3D protein structure www.nature.com/articles/s41...

11.02.2026 10:46 β€” πŸ‘ 27    πŸ” 10    πŸ’¬ 0    πŸ“Œ 1

Honored to be a finalist for the 2026 Blavanik Awards in the UK in Life Sciences. I’m grateful to past and present lab members, collaborators, colleagues and mentors, who made it possible. It’s even better to share this from
Vietnam while celebrating the Tet holidays with family.

10.02.2026 10:19 β€” πŸ‘ 84    πŸ” 10    πŸ’¬ 12    πŸ“Œ 0

Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!

06.02.2026 11:20 β€” πŸ‘ 84    πŸ” 29    πŸ’¬ 8    πŸ“Œ 3
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Programmable genome editing in human cells using RNA-guided bridge recombinases Site-specific insertion of gene-sized DNA fragments remains an unmet need in the genome editing field. IS110-family serine recombinases have recently been shown to mediate programmable DNA recombinati...

πŸ§¬πŸŒ‰Online @science.org Programmable genome editing in human cells using RNA-guided bridge recombinases | Science www.science.org/doi/10.1126/...

06.02.2026 00:12 β€” πŸ‘ 38    πŸ” 13    πŸ’¬ 1    πŸ“Œ 0

Congratulations on the well-deserved honor Karolin!

02.02.2026 20:05 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Here is the official announcement. Now more than ever, acknowledging the contributions of immigrants is so important. Thank you @vilcekfoundation.bsky.social, and congrats to my fellow awardees. Can't wait to meet you all.

02.02.2026 18:37 β€” πŸ‘ 62    πŸ” 15    πŸ’¬ 3    πŸ“Œ 1
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Hallmarks of cancerβ€”Then and now, and beyond Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilities, enabling traits, microenvironmental players, and systemic interactions converge to drive tumorigenesis and proposes that mechanism-guided co-targeting of hallmarks may offer promising therapeutic strategies.

Now online! Hallmarks of cancerβ€”Then and now, and beyond

30.01.2026 23:38 β€” πŸ‘ 10    πŸ” 6    πŸ’¬ 0    πŸ“Œ 1
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Second PhDone from our lab. Congrats Seb! What a start to 2026, a paper out, a successful PhD defense, two new members and two visits from our collaborators Michael Stone and @janovictom.bsky.social! Can’t be more grateful but time for a short break with family in Vietnam πŸ‡»πŸ‡³.

30.01.2026 09:19 β€” πŸ‘ 33    πŸ” 1    πŸ’¬ 2    πŸ“Œ 0
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New pre-print from the lab! Lead by Mariia Mikhova and in collaboration with Kefei Yu’s lab @msumgi.bsky.social we dug into the molecular mechanism of class switch recombination in B cells using simultaneous RNA and protein single-molecule imaging. 1/n
www.biorxiv.org/content/10.6...

23.01.2026 14:48 β€” πŸ‘ 7    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0

Thank you very much Pleasantine!

23.01.2026 21:18 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle - Nature Communications To maintain genome stability, the specialised reverse transcriptase telomerase processively adds telomeric DNA repeats to chromosome ends. Here the authors reported structures of human telomerase at t...

Excited to share our latest work on dissecting the mechanism of processive telomeric DNA synthesis by telomerase. Led by amazing PhD student Sebastian Balch in collaboration with lab members,@automnenine.bsky.social @rachael-kretsch.bsky.social,@rdaslab.bsky.social.
www.nature.com/articles/s41...

23.01.2026 06:57 β€” πŸ‘ 51    πŸ” 15    πŸ’¬ 2    πŸ“Œ 2

Tom Cech on RNA research in Davos (video): www.weforum.org/meetings/wor...

21.01.2026 21:24 β€” πŸ‘ 16    πŸ” 9    πŸ’¬ 0    πŸ“Œ 1

Congratulations Dawid! Very excited for you!

21.01.2026 13:30 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)

06.01.2026 15:16 β€” πŸ‘ 89    πŸ” 29    πŸ’¬ 2    πŸ“Œ 4

🚨 Interdisciplinary PhD opportunity for graduates interested in DNA replication, chromatin biology, and cancer research. Please share with potential candidates.

31.12.2025 09:52 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

We have an opening for a research support officer. Come and join us! Please share.

22.12.2025 12:09 β€” πŸ‘ 17    πŸ” 22    πŸ’¬ 0    πŸ“Œ 0
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PhD Studentship: Understanding How Centromere Replication Fails in Cancer Imperial College London & The Institute of Cancer Research (CRUK Convergence Science Centre) at Institute of Cancer Research o... PhD Project - PhD Studentship: Understanding How Centromere Replication Fails in Cancer Imperial College London & The Institute of Cancer Research (CRUK Convergence Science Centre) at Institute of...

We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) β€” a major driver of tumour evolution and therapy resistance.

tiny.cc/vilw001

#PhD #CancerResearch #GenomeStability #Chromatin

18.12.2025 15:46 β€” πŸ‘ 8    πŸ” 6    πŸ’¬ 1    πŸ“Œ 2
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Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...

16.12.2025 16:29 β€” πŸ‘ 83    πŸ” 23    πŸ’¬ 2    πŸ“Œ 1