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Kelly Nguyen

@kellythd-nguyen.bsky.social

Group Leader @MRC_LMB /Structural Biologist/Biochemist. Amateur baker in free time #RNAworld #spliceosome #telomerase #telomeres #cryoEM #Xraycrystallography

873 Followers  |  432 Following  |  43 Posts  |  Joined: 23.11.2024  |  2.1234

Latest posts by kellythd-nguyen.bsky.social on Bluesky

Ana Tufegdžić Vidaković at a lab bench

Ana Tufegdžić Vidaković at a lab bench

Congratulations to @anatv.bsky.social, Group Leader in the LMB’s PNAC Division, who has joined @embo.org’s Young Investigator Programme!
Read more about the programme and Ana’s research here: www2.mrc-lmb.cam.ac.uk/ana-tufegdzi...
#LMBNews

02.12.2025 13:05 — 👍 18    🔁 3    💬 1    📌 0
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AI RNA Design for Developing Antiviral Solutions in Sugar Beet (Plant BioDesign JIC project) at University of York on FindAPhD.com PhD Project - AI RNA Design for Developing Antiviral Solutions in Sugar Beet (Plant BioDesign JIC project) at University of York, listed on FindAPhD.com

New PhD opportunity available in my lab, in collaboration with Betty Chung (Cambridge), focusing on plant RNA viruses and AI-driven design. www.findaphd.com/phds/project...

28.11.2025 23:36 — 👍 3    🔁 9    💬 0    📌 0
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Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social

www.biorxiv.org/content/10.1...

18.11.2025 22:43 — 👍 58    🔁 20    💬 1    📌 1
HMS - Postdoctoral Fellow in BCMP, Brown Lab We invite applicants for a postdoctoral fellow position in the Brown lab at Harvard Medical School in Boston, Massachusetts. The Brown lab uses structural, biophysical, and biochemical approaches to d...

Our lab is seeking a Postdoctoral Fellow. The position is intentionally broad, as we are looking for outstanding researchers from diverse scientific backgrounds to advance our understanding of cilia and ciliopathies: academicpositions.harvard.edu/postings/15526

18.11.2025 20:05 — 👍 19    🔁 19    💬 0    📌 1
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Structural basis of herpesvirus helicase-primase inhibition by pritelivir and amenamevir Structural studies of HSV-1 helicase-primase revealed how pritelivir and amenamevir bind and block its helicase activity.

New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development.
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social

10.11.2025 00:14 — 👍 34    🔁 13    💬 1    📌 1
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An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

07.11.2025 10:44 — 👍 385    🔁 171    💬 10    📌 22
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Phosphorylation-dependent tuning of mRNA deadenylation rates - Nature Structural & Molecular Biology Stowell et al. show that the intrinsically disordered region (IDR) of Puf3 binds the Ccr4–Not deadenylase complex using an extended interface. Phosphorylation of the IDR regulates the interaction to t...

The latest from our group (@lapassmore.bsky.social)! Congrats to James and the rest of the authors!

Phosphorylation-dependent tuning of mRNA deadenylation rates

www.nature.com/articles/s41...

03.11.2025 12:45 — 👍 13    🔁 4    💬 0    📌 0
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Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs

06.11.2025 15:46 — 👍 27    🔁 23    💬 1    📌 0
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Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...

04.11.2025 17:19 — 👍 35    🔁 39    💬 1    📌 1

Congratulations 🎊!

04.11.2025 21:38 — 👍 1    🔁 0    💬 0    📌 0
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Wilkinson Lab We discover and study reverse transcriptases

The Wilkinson Lab is open for science! @mskcancercenter.bsky.social

🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬

annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)

31.10.2025 19:00 — 👍 93    🔁 45    💬 5    📌 3

Definitely one to watch. Girish’s love for science is just infectious for those around him.

31.10.2025 09:06 — 👍 4    🔁 0    💬 0    📌 0

Excited to see this cool discovery out in its final form. Congratulations CJ and team!

31.10.2025 06:58 — 👍 7    🔁 0    💬 1    📌 0
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Researchers Link Mutations in RPA Protein to Cancer, Other Diseases Researchers in the Lim Lab reveal that dysfunction in a protein essential to maintaining stability in our chromosomes may be responsible for serious diseases.

Research from Professor Ci Ji Lim's (@cijilim.bsky.social) lab, published today in @science.org, could provide patients and doctors with new protein mutations to test for certain cancers and bone marrow diseases. Read more: biochem.wisc.edu/2025/10/30/r...

30.10.2025 19:35 — 👍 12    🔁 3    💬 0    📌 0
Quick Check Needed

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.

mrc.tal.net/vx/appcentre...

29.10.2025 09:17 — 👍 64    🔁 57    💬 2    📌 2
Cryo-EM maps and atomic models of the biotin-containing 3-methylcrotonyl-CoA carboxylase (MCC) complex and long-chain acyl-CoA carboxylase (LCC) complex

Cryo-EM maps and atomic models of the biotin-containing 3-methylcrotonyl-CoA carboxylase (MCC) complex and long-chain acyl-CoA carboxylase (LCC) complex

New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz

30.10.2025 03:21 — 👍 82    🔁 29    💬 3    📌 1
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In Memoriam: William Scott The longtime professor of chemistry and biochemistry is remembered by family, friends, and colleagues for his immense intellect, generosity, and contributions to advance scientific research

The LMB was saddened to hear of the death of #LMBAlumni Bill Scott, who was a postdoc at the LMB working with Aaron Klug from 1993-1996. During this time he won the LMB’s postdoctoral prize for outstanding research.
Read more about Bill from @ucsantacruz.bsky.social: news.ucsc.edu/2025/10/in-m...

30.10.2025 10:07 — 👍 9    🔁 4    💬 0    📌 0
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📢 Excited to share that our study has just been published in Nature Communications! We uncover how CRL4-DCAF12 regulates the cellular levels of MCMBP, a chaperone essential for assembling nascent MCM2-7 complexes, to ensure accurate and error-free genome duplication.

28.10.2025 15:04 — 👍 20    🔁 8    💬 4    📌 0

Exciting findings by the Sternberg lab! Very cool!

17.10.2025 18:46 — 👍 4    🔁 0    💬 0    📌 0
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Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...

16.10.2025 19:17 — 👍 178    🔁 56    💬 9    📌 5
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Hijacking a bacterial ABC transporter for genetic code expansion - Nature Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...

🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...

it all started years ago with a failed experiment
🧵👇 1/9

16.10.2025 14:06 — 👍 210    🔁 59    💬 20    📌 14
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Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...

New paper out now in Science! Check it out!
www.science.org/doi/10.1126/...

16.10.2025 18:17 — 👍 37    🔁 8    💬 2    📌 1
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Postdoctoral Research Assistant - MCDB - UOD2016 Closing date: Thursday 6 November 2025, 23:59

Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.

www.dundee.ac.uk/work-for-us/...

15.10.2025 12:53 — 👍 38    🔁 35    💬 0    📌 3
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Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

06.10.2025 13:36 — 👍 42    🔁 19    💬 1    📌 4
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Postdoc - Telomere and Genome Maintenance | Werken bij AVL The research group of Jacqueline Jacobs at the division of Oncogenomics aims to identify new factors and molecular mechanisms that are critical in telomere and genome maintenance through appropriate D...

Are you a postdoc looking for a new challenge and do you match the profile? Apply to join us! Especially, if you have experience with addressing the mechanisms underlying telomere maintenance, DNA replication or DNA repair. www.werkenbijavl.nl/vacatures/po...

06.10.2025 13:25 — 👍 7    🔁 6    💬 0    📌 1
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The mechanistic basis of cargo selection during Golgi maturation Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

06.10.2025 11:39 — 👍 53    🔁 22    💬 0    📌 1
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ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...

02.10.2025 22:55 — 👍 88    🔁 35    💬 4    📌 0

Congratulations Camille!

03.10.2025 18:22 — 👍 1    🔁 0    💬 0    📌 0
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Technician III - Department of Microbiology Position Summary This position will be in the lab of Dr. Joseph E. Peters in the Department of Microbiology. Research in the Peters’ lab broadly involves deciphering mechanisms in genome stability and...

The Peters lab is looking for a new team member! The role transposons play in evolution, basic mechanisms regulating transposition, and applying transposons as tools for genome modification with a special focus on guide RNA-directed transposition. cornell.wd1.myworkdayjobs.com/CornellCaree...

03.10.2025 13:01 — 👍 27    🔁 21    💬 2    📌 0
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Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

29.09.2025 19:09 — 👍 93    🔁 25    💬 8    📌 5

@kellythd-nguyen is following 20 prominent accounts