Alan Parker

Great to have this out as a preprint - a fantastic collaborative effort led ably by the dream team of Rosie and Kasim....have a look, the structures are amazing!

Great to have this out as a preprint - a fantastic collaborative effort led ably by the dream team of Rosie and Kasim....have a look, the structures are amazing!

Potential @gw4biomeddtp.bsky.social 4 year PhD project for Oct 2026 start adopting machine learning to develop precision virotherapies - co-supervisors Yukun Lai, @mariekedoesscience.bsky.social, Kerry Wadey & Julian Fischer. Come, make some smart viruses with us!

gw4biomed.ac.uk/developing-p...

next meeting Friday 5th September 1-2.30pm at Cancer Genetics Building, University Hospital of Wales, Cardiff CF14 4XN

Make sure you don't miss our next #Advancedtherapies MDRG on Friday.

Hear from Dr Michael Chapman -'CAR-T therapy in haematological malignancy' and Professor Andrew Sewell 'How T-Cells clear cancer'

Virtual option available

#Research

@alanlparker.bsky.social @lifesciencescymru.bsky.social

An αvβ6-specific virotherapy expressing bispecific immune cell activators induces immune cell activation to mediate tumor cell death Virotherapies can deliver anti-cancer therapeutics directly to tumors. Bayliss and colleagues develop a precision virotherapy expressing bispecific immunotherapies from tumor cells resulting in immune...

Very excited our paper describing the development of a precision Virotherapy directly delivering bispecific molecules to tumour cells is in it's final polished form!
www.cell.com/molecular-th...

Eisteddfod sign on the maes

Image of paper virus templates, and materials used for building

Image of our build a virus stand

Am Sdeddfod wych!! Diolch o galon i bawb ddaeth i'n gweld ni ym mhabell @prifysgolcdydd.bsky.social, i ddysgu mwy am ein gwaith yn Uned firoleg gymhwysol Cymru Wales Applied Virology Unit (WAVU). Braf odd cal gweld y "firysau" oddachi wedi ei greu o gwmpas y maes!

Doh! 🤦🏻‍♂️. Thanks for seconding anyway 😂👍🏻

If you’re visiting #Eisteddfodd today, do speak to the awesome @lunedbadder.bsky.social representing @cardiffunilib.bsky.social, the VITAL lab & HCRW Wales Applied Virology Unit (WAVU), explaining how we develop “#SmartViruses” to treat #Cancer. You can even make a designer virus of your own!

Congratulations to @gw4biomeddtp.bsky.social @atwales.bsky.social funded PhD student Rosie Mundy, presenting her groundbreaking structural and transcriptomic analysis of Ad10 today at the International Adenovirus Meeting at @cardiffunilib.bsky.social centre for student life.

Big moment for the youngest, collecting his first cap for @glamcricket.bsky.social U13 yesterday. Two terrific matches against a strong Gloucestershire U13 but showed their class securing back to back T20 wins. Exciting times ahead! 👏👏🏏 💥

Thanks for inviting me to be an honorary @pharmacycu.bsky.social member for and to talk "how to train your virus" at the ever wonderful @pintofscience.uk event at Tiny Rebel, Cardiff! A great evening talking about crossing the "Valley of Death" and into the clinic with our "smart viruses".

A photograph of Alan Parker next to text describing his talk on "How to train your virus" for Pint of Science 2025

Looking forward to my favourite #PublicEngagement event @pintofscience! I'll talk "how to train your virus" at @TinyRebelCdff on 20/05, discussing how we turned a disease causing "nasty" into a clinical stage anticancer medicine. Grab a pint, pop along! pintofscience.co.uk/event/from-b...

Health and Care Research Wales announces appointments of Senior Research Leaders

Thrilled and honoured to be announced as a Health and Care Research Wales Senior Research Leader. Looking forward to contributing towards accelerating translational research, shaping policy and mentoring the next generation of researchers in Wales.

healthandcareresearchwales.org/about/news/h...

Reposting the job link!

krb-sjobs.brassring.com/TGnewUI/Sear...

Join our new Wales Applied Virology Unit as a Lecturer in Infectious Disease Epidemiology / Behavioural Science!

See the advert here:

krb-sjobs.brassring.com/TGnewUI/Search…

And contact WAVU co-director David Gillespie for informal enquiries.

#NewPI #Lecturer #GroupLeader #Job #Opportunity

Well, this is exciting, and has been a long time in the making. Many thanks to the many, many exceptional authors for their expert contributions. Would make a lovely Easter gift....(who needs chocolate eggs, right...?)

Fantastic talk from Prof Stephanie Schorge - discussing the path to translation for taking a lentiviral therapy for epilepsy from preclinical to clinical translation! A rollercoaster of a journey many of us can relate to!

Great to be over in London today UCL institute for child heath for what promises to be an awesome day of #AdvancedTherapies #UCL2025AdvTx . Thanks @atwales.bsky.social for funding my trip over! Looking forward to a great day!

Fantastic to have you there representing us today @alanlparker.bsky.social

#AdvancedTherapies

Thanks Lindsay, glad you liked the video! Hopefully I’ll catch you at some point to say hello…

Huge congrats 🥂 to our latest virus tinkerer fledgling Dr Adam Naskretski MD! What a journey it’s been but my goodness you have deserved it! Many thanks to fabulous viva panel Fiona Errington-Mais, Mererid Evans and @alextonks.bsky.social for chairing! 👏🎉👍🏻🥳🦠

Investigating endothelial cell transduction and hexon:PF4 binding of ChAdOx1 in the context of VITT Background: Vaccines against SARS-CoV2 have been essential in controlling COVID-19 related mortality and have saved millions of lives. Adenoviral (Ad) based vaccines have played an integral part in th...

Scientists found that the AstraZeneca COVID-19 vaccine can infect endothelial cells but doesn’t activate them, suggesting it’s not a direct cause of VITT.

The vaccine’s hexon protein binds PF4, supporting a role in triggering the immune response.

www.biorxiv.org/content/10.1...

Investigating endothelial cell transduction and hexon:PF4 binding of ChAdOx1 in the context of VITT Background: Vaccines against SARS-CoV2 have been essential in controlling COVID-19 related mortality and have saved millions of lives. Adenoviral (Ad) based vaccines have played an integral part in th...

Preprint klaxon: Investigating endothelial cell transduction and hexon:PF4 binding of ChAdOx1 in the context of VITT.

Providing evidence of direct PF4 binding to purified hexon protein, & efficient, CAR independent transduction (but not activation) of ECs by ChAdOx1

www.biorxiv.org/content/10.1...

Investigating endothelial cell transduction and hexon:PF4 binding of ChAdOx1 in the context of VITT https://www.biorxiv.org/content/10.1101/2025.03.09.642192v1

Investigating endothelial cell transduction and hexon:PF4 binding of ChAdOx1 in the context of VITT https://www.biorxiv.org/content/10.1101/2025.03.09.642192v1

Our virus tinkerers are out today at the Sbarc/Spark building for “be a scientist” day! If you’re looking for an interactive event to inspire the kids this half term, why not come down and build a virus - and learn all about how we are making “smart viruses” to treat disease! 🦠

Indeed. Very sad it has come to this....

whoops sorry! Your silhouette bears a passing resemblance to the relevant person with the same name! Apologies! :)

If you were at the Ty Dewi Sant building, you obviously missed the security presence. They were just outside the lecture theatre just in the underpass outside. I remember being shocked to see their presence.