Elizabeth Rideout

Screenshot of the FlyCyc page at https://biocyc.org.

We have recently updated FlyCyc biocyc.org/DMEL/organis..., the pathway-genome database representing Drosophila metabolism, to include enzymatic complexes as well as further improvements to enzyme annotations. #FlyCyc is now classed as a ‘Tier 1 Highly Curated Organism Database’.

Now published as version of record at @elife.bsky.social !

Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️)

elifesciences.org/articles/107...
shop.vbc.ac.at/vdrc_store/d...

#Drosophila #IDsky #SymbioSky #Infection #Immunology

✨A gut feeling you’ll love this one 🐛 The anterior midgut of a Drosophila melanogaster 🪰larva puts on a confocal glow show! 🟢 Adult midgut progenitors 🔴 Actin 🔵 Nuclei 📸Image by Sapna Krishnakumar #FluorescenceFriday #Microscopy #DevBio

Islet Biologists in 🇨🇦 🏆 @cirtn.bsky.social

FlyBase secures funding for year, but future still uncertain The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.

🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off.

Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2

tinyurl.com/FlyBase

📣Tomorrow is International #DayoftheGirl
& 30 years since the Beijing Declaration on advancing equity, development & peace for all women & girls

📈We must scale investment in girls — including through research, health, education & empowerment-

-a commitment we make in our lab

#GenerationEquality

Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling Burgmer et al. show that the pattern recognition receptors (PRRs) PGRP-LC and PGRP-LE repress key metabolic functions in the Drosophila midgut. These regulations occur independently of canonical immun...

Burgmer, S., Meyer Zu Altenschildesche, F., Gyenis, A., Lee, H., Vilchez, D., Giavalisco, P., Fichant, A., Uhlirova, M., Storelli, G. (2025). Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling. Cell Rep, 44(6):115811 www.cell.com/cell-reports...

Another amazing achievement from the fly community 🤩

Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.

💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF

🪰 More than 750 scientists from 40+ countries gathered in Alicante for the XXVIII European Drosophila Research Conference #EDRC2025.
For 4 days, the fruit fly took center stage as a model to study health, aging, and disease👏
@edrc2025.bsky.social
@csic.es @dicv.csic.es @umh.es

Thank you to all #EDRC2025 participants and a big applause to the organizing committee for this great #Drosophila meeting! See you all in Bonn for #EDRC2027

#edrc2025 European #drosophila Society meeting announces the 2029 meeting location : see you all in Szeged (and Bonn in 2027 of course)!

Beautiful location, fabulous science, and wonderful people 🤩 Thanks to the organizers for all your hard work in bringing us together!

What causes endometriosis? Scientists are closer to finding out : Short Wave Since the age of nine or ten, Katie Burns has had debilitating pain from endometriosis, a condition where tissue resembling the uterine lining grows outside the uterus. For years, Katie was in the dar...

Interesting episode of short wave about the origin of endometriosis. I really appreciate that they end with how uncertainty in NIH funding affects the future of their work.

www.npr.org/2025/09/26/n...

Not going to lie…I have gotten very distracted by this feature before 😂

Graphical summary of the paper, showin several plots from the manuscript, including a phylogenetic tree of bivalves.

2nd paper outta my PhD is NOW PUBLISHED😭

🧬🖥️ 🦑Here we show how comparative #genomics 🧬 is a powerful tool to detect putative #SexDetermination genes: Dmrt1L & SoxH from #bivalves 🦪 share evolutionary patterns with Sry from #mammals 🐗 but not with genes from
#drosophila 🪰

doi.org/10.1111/mec....

Tropical fish aquarium at Vancouver airport.

Taking in my favorite part of Vancouver airport on the way to EDRC in Alicante - excited to see folks there for all things Drosophila!

Thank you!!

Thank you!!

Dear JEDIs, the #EDRC meeting is coming soon! Who is joining? Looking forward to meeting everyone next week!

α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion α cells can generate and secrete both glucagon and GLP-1 with distinct processing enzymes to control metabolism.

Studies of prohormone convertase knockouts in mouse islets reveal plasticity in proglucagon processing to support intra-islet α cell-to-β cell communication, normally dominated by glucagon secretion www.science.org/doi/10.1126/...

Feeling fortunate to have contributed data to this effort led by Dr Soumitra Pal, Dr Teresa Przytycka, Dr Brian Oliver, along with Dr George Vogler and Dr Frank Schnorrer. Puja in the lab also produced data on fat body cell counts.

Cell type specific allometry controls sex-differences in Drosophila body size Species and sex-specific differences in organ size are fundamental features of animal biology, yet the mechanisms that drive these differences remain debated. Adult female Drosophila are larger than m...

Very proud of Celena Cherian in the lab, who contributed data to www.biorxiv.org/content/10.1... Briefly, Celena showed female fat body cells have higher ribosomal protein expression and more protein synthesis than males. This difference persists even after cell size is accounted for!

Gut hormone signaling drives sex differences in metabolism and behavior Males and females have different physiological and reproductive demands, and consequently exhibit widespread differences in metabolism and behavior. One of the most consistent differences across anima...

Supporting and extending these data, Dr Kim Rewitz’s lab has posted a beautiful paper on this topic www.biorxiv.org/content/10.1... We were fortunate to have lots of great discussions about these data!

There are lots of interesting questions left from this work, but we were excited to report such a strong sex difference in these cells.

Puja’s data suggests that Tachykinin and Allatostatin C act on neurons to mediate this effect on fat storage. However, the subset of neurons upon which they act is unclear (but was not the insulin- or Akh-producing cells).

Because these hormones affect behavior and physiology, Puja tested whether this female biss in hormone production affected fat storage. She found Tachykinin and Allatostatin C contribute to greater fat storage in female flies with no effect in males.

Briefly, Puja saw a strong female bias in mRNA levels of hormones produced by gut enteroendocrine cells. This sex bias was not caused by sex determination gene transformer.

Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage in Drosophila females Enteroendocrine (EE) cells in the Drosophila gut produce and release multiple factors, including Allatostatin A (AstA), Allatostatin C (AstC), neuropeptide F (NPF), tachykinin (Tk), Diuretic hormone 3...

The next paper from @pujabiswas.bsky.social PhD has been posted! www.biorxiv.org/content/10.1... Puja found a sex difference in levels of hormones produced by gut enteroendocrine cells.

I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.