Jürg Bähler

Someone requested #GoldenBraid Assembly, now it's live on #OpenCloning. Still missing the omega Level 1 assembly (coming very soon).

For GoldenBraid reference: goldenbraidpro.com and pmc.ncbi.nlm.nih.gov/articles/PMC...

#OpenCloning is shaping up to be a really useful tool, and the new Assembler is powerful for defining and using Golden Gate syntaxes. Give it a try!

Pombase gene page with an arrow pointing at the link to OpenCloning

🚀 Update from @pombase.bsky.social!

Gene pages now link to OpenCloning. Load the gene region instantly and design primers + cloning strategies in one click 🧬🧪✨

To get started with OpenCloning, check the docs: docs.opencloning.org

and this one, with @jbahler.bsky.social:

www.trees-dla.ac.uk/projects/evo...

For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org/doi/full/10....

Here's an important and topical perspective from Nektarios Tavernarakis. Wise words!

PomBase introduces two new interactive views for GO-CAM pathway models: Summary Maps (high-level, visual overview) and Mega-Models (connected models). Check them out here: lnkd.in/gfxNRdua

Psilocybin treatment extends cellular lifespan and improves survival of aged mice - npj Aging npj Aging - Psilocybin treatment extends cellular lifespan and improves survival of aged mice

Well this is interesting: Psilocybin treatment extends cellular lifespan and improves survival of aged mice

Guess all of us older adults need to stock up on mushrooms!!!

www.nature.com/articles/s41...

The adaptive molecular landscape of reprogrammed telomeric sequences Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequen...

Superhappy to share the last paper from my PhD in @litinice.bsky.social lab. We evolved yeasts with humanized telomeric repeats and discovered that they adapt through amplification of telomere-binding proteins and inactivation of the DNA damage response.

www.biorxiv.org/content/10.1...

After 25 years, it was wonderful to reunite with all members of our original research group!

FlyBase needs your help!

Because of recent changes to government funding, the NIH grant that supported FlyBase has been "terminated." flybase.org

Header with images of cultured cells and a Drosophila brain. Text below reads: We are excited to be recruiting our team of 3 post-doctoral research fellows to study the mechanisms underlying ageing-dependent glial cell dysfunction and its effects on neurodegeneration! This is a three-year Medical Research Council-funded cross-disciplinary, multi-partner project with one post-doctoral fellow at each site: Edinburgh Napier, University of Glasgow, and UCL. If you are interested in glial cell biology/neurodegeneration, functional genomics and bioinformatics please get in touch or apply below: Astrocyte ageing & Bioinformatics: Fiona Kerr, ENU (f.kerr@napier.ac.uk): Apply here: Closing Date: https://jobs.napier.ac.uk/mthrprod_webrecruitment/wrd/run/etrec179gf.open?WVID=150547JMmr&LANG=USA Tuesday 24th June 2025 Microglial Ageing & Bioinformatics: Dervis Salih, UCL (dervis.salih@ucl.ac.uk): Apply here: https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details?jobId=35013&jobTitle=Research+Fellow Closing Date: Thursday 26th June 2025 Drosophila models of neurodegeneration: Nathan Woodling, University of Glasgow (nathan.woodling@glasgow.ac.uk): Apply here: https://www.jobs.gla.ac.uk/job/research-associate-49?source=gla.ac.uk Closing Date: Wednesday 25th June 2025

We are excited to be recruiting 3 post-doctoral researchers to study glial cell dysfunction in #agingresearch and #neurodegeneration, including one position using #Drosophila models! If you are interested, please read more below to get in touch or apply (links in thread).

New drug cocktail makes mice live 30% longer – Andrew Steele Rapamycin + anti-cancer drug trametinib does better than rapa on its own!

We found a new way to make mice live 30% longer! 🧪 #aging #longevity #rapamycin

A combination of classic longevity drug rapamycin with cancer drug trametinib was more effective than either on its own.

Read more about the exciting results here:

We will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers.

As well as ambitious proposals for R&I in the next EU budget.

We will also offer the best and brightest the right incentives to come to Europe ↓

The Economist cover 👀

So, essentially it can’t be just a coincidence…

A periodic reminder to cite your resources. Although no @pombase.bsky.social update in this issue, we did sneak onto the cover illustration.

I spent a very nice couple of days at the "Hidden Cell, Dark Genome" conference in Edinburgh last week ... and even got to win a supercute eukaryotic cell 🙂 Thanks to the organisers for arranging the meeting!

You can now ✅ verify your #OpenCloning sequences using sequencing data 🧬 (Sanger or Nanopore). Just load your files 📂 and see where they align! 🎯

#OpenCloning is free & Open Source, and supports most cloning methods! 🔬🛠️

👉 Try it here: opencloning.org
🎞️ Demo video: youtu.be/n0hedzvpW88?...

Science under siege: protecting scientific progress in turbulent times As Editors-in-Chief of The Company of Biologists' journals, we have been watching with growing concern the policy changes in the United States of America (USA) and the challenges that these are creati...

Together with fellow @biologists.bsky.social EiCs we've written about the unprecedented cuts & policy changes to research in the US

We stand with our US colleagues during this challenging time

Science transcends borders—setbacks in one nation affect us all

journals.biologists.com/dev/article/...

Digital sovereignty – Huber Group @ EMBL The US is now a mafia-style extortionist you want to stay away from

It's time for individuals and organizations in Europe and other democratic countries to move mission- or life-critical IT services and infrastructure outside the reach of the US government; noting that US tech companies have already largely subordinated themselves.

www.huber.embl.de/group/posts/...

Text: EMBO is on Bluesky. Butterfly icon with text: @embo.org

Hello everyone on Bluesky! 🧪

We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond.

Read more: www.embo.org/about-embo/m...

Grant rejections got you feeling low?

BSRA research grants have success rates between 35-67%! We offer our members
- Small Research Grants
- Travel Grants
- Summer Studentships

Next deadline 1st March. Know the perfect person? Tag them below!

bsra.org.uk/bsra-open-gr...

'Many of us...have a feeling that we are living in a country where fanatics, hooligans and eccentrics have got the upper hand.'

British Ambassador to Berlin, 1933.

UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

You can apply to our postdoc position until 12 Jan:

We are looking for a Postdoc in Functional Genomics to examine the roles of conserved yet unstudied proteins, focusing on cellular quiescence and ageing.

www.ucl.ac.uk/work-at-ucl/...

Global Biodata Coalition on LinkedIn: Thank you to leading scientists around the world for signing the GBC’s… Thank you to leading scientists around the world for signing the GBC’s Open Letter calling for support to sustain global biodata resources. If you haven’t…

www.linkedin.com/posts/global...

Second PhD project now online, co-supervised by @jbahler.bsky.social. Join us to work on the genetic architecture of environmental responses in fission yeast. Tons of existing data and resources (wild strains, MA lines, evolved populations...) to dig into.

www.trees-dla.ac.uk/projects/evo...

Joao Pedro de Magalhaes on LinkedIn: DrugAge Database of Anti-Ageing Drugs A new version of the DrugAge database of ageing-related drugs is now available online. It features 1,046 longevity drugs/compounds and >3,000 entries in…

www.linkedin.com/posts/joaope...

EASTBIO: Harnessing Transposon Mutagenesis to Dissect Antifungal Drug Resistance in the Fungal “Superbug” Candidozyma auris at University of Aberdeen on FindAPhD.com PhD Project - EASTBIO: Harnessing Transposon Mutagenesis to Dissect Antifungal Drug Resistance in the Fungal “Superbug” Candidozyma auris at University of Aberdeen , listed on FindAPhD.com

There is competitive #PhD funding for 4 years (eligibility criteria apply) to do a project on the human pathogen Candidozyma (Candida) auris dissecting the genetic basis of its antimicrobial resistance #AMR www.findaphd.com/phds/project... - pls repost

OK Pinterest, I see where you are coming from

Please add me to the Aging Pack.