Mariah Lelos

Check out our latest paper: PET and MR imaging of human stem cell derived dopamine grafts. Relationship between PET and different types of behaviour, evidence of glial remodeling in distal areas, and more!

shorturl.at/j9z4r

Join us online on World Parkinson's Day (Friday) to hear from leading scientists in informative sessions & panel discussions🧠🙌

Dr Dayne Beccano-Kelly, Dr @riahlelos.bsky.social & Prof Caleb Webber share their latest research into Parkinson's.

⏰ 11:15 - 15:15 on Friday 11 April 👉 buff.ly/5wlA3dx

www.thebrainrepairgroup.com. Check out our new website! Designed and made by a very talented PhD student in the lab, Phoebe Linehan

👋 Greetings from the Brain Repair Group in Cardiff, UK 👋

Amazing news Alan - huge congratulations!!

Cell therapies are in clinical trial for Parkinson's disease, epilepsy and other CNS indications. Here we show that glucose deprivation causes rapid cell death, more so than oxygen deprivation. Improving access to glucose in grafts could improve graft survival

pubmed.ncbi.nlm.nih.gov/39788838/

Interesting:
New research reports in vivo evidence that cholinergic degeneration represents a principle pathological correlate of cortical hypometabolism underlying cognitive impairment in #Parkinsons (N=95 PD participants)
www.nature.com/articles/s41...

Yes please! 👋

Glad you've started this one! Please can I be added? 👋

🚀Thrilled to announce #inTRACKtive: a web-based tool for exploring massive cell-tracking datasets, no software installation required! Open your browser and dive into terabytes of developmental biology data 🐭🪰🪱🪲🐠

Preprint:
biorxiv.org/content/10.1...

Repository:
github.com/royerlab/inT...

🧵1/n

*Highly recommend* a simple plug in called Color Oracle: colororacle.org It’s a free color blindness simulator. Just one click, it shows you in real time what people with common color vision impairments will see on your screen. I use it to doublecheck everything! #microscopy #figures #academicsky

@mjafreeman.bsky.social's BlueSky starter packs for 'mechanistic' biologists

Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras

Complete with collective nouns

I’ve been tracking these but now can’t keep up

Hope it’s helpful

2/2

docs.google.com/spreadsheets...

Wow! Please post when the paper comes out from this experiment. I'd love to see the striatal transcriptomic data

Thanks for creating this! I'd love to be added if there is still space 🧠🔬🧬🧪

Please could I be added? This is exactly what I do. Thanks! 🧠

Thank you!

Yes please 👋 studying Parkinson's and Huntington's 🧠

Epigenetic memory of Lateral Ganglionic Eminence derived hiPSCs cannot overcome barriers in authentic MSN differentiation Induced pluripotent stem cells (iPSCs) have previously been shown to retain some of the epigenetic features associated with the tissues from which they were derived, which in turn can help the iPSCs t...

For all those stem cells biologists differentiating hPSCs to neurons, want to know how the epigenetic memory of the donor tissue affects subsequent differentiation? We explore this in our recent paper 👇
shorturl.at/m23WC

Come join us from a post-doctoral research position studying immune signalling changes in motor neuron disease. Microglia, chimeras and human brain tissue will be used to tackle these exciting questions 🧠 shorturl.at/GCUSy

Yes please!

Yes please!