Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis - Nature Immunology Rathmell and colleagues show that metabolic reprograming of regulatory T cells is associated with severity of critical illness in patients with and without sepsis.

How does sepsis alter T-cell function? Terrific new paper led by Matt Stier and colleagues @VUMC explores this using complementary single-cell methods www.nature.com/articles/s41...

Vanderbilt Transplant Center nation’s largest after performing record number of solid organ transplants in 2025 The Vanderbilt Transplant Center performed 960 solid organ transplants in 2025, the most ever done by a single center in one year.

This is an incredible accomplishment by the amazing transplant teams at VUMC - 149 lungs transplants (and a few more in dual-organ) in 2025.

news.vumc.org/2026/01/14/v...

Denoising image-based spatial transcriptomics data with DenoIST Image-based spatial transcriptomics (IST) technologies provide unprecedented resolution of gene expression in tissue sections, but suffer from contamination of cells' gene expression profiles due to i...

Great new work led by Aaron Kwok from @davisjmcc.bsky.social’s group. A tool to “denoise” contaminating transcripts from image based spatial data.

www.biorxiv.org/content/10.1...

A show of bipartisan support for NIH. Basically flat except for ARPA-H.

The President’s budget proposal basically ignored (as it should have been).

A spatial transcriptomic atlas of acute neonatal lung injury across development and disease severity | American Journal of Physiology-Lung Cellular and Molecular Physiology | American Physiological So... A molecular understanding of lung organogenesis requires delineation of the timing and regulation of the cellular transitions that ultimately form and support a surface capable of gas exchange. While ...

So excited to share @saahimall.bsky.social just had her her first 1st author publication published in AJP lung! Huge accomplishment!!! This study wouldn't have been possible without the amazing @jensucre.bsky.social!

journals.physiology.org/doi/abs/10.1...

Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!

Congrats to @saahimall.bsky.social on her first study from her PhD! Also, science is always more fun when done with friends. Great to work as always with @jensucre.bsky.social and @jkropski.bsky.social!

New spatial paper from Saahi and VUMC/TGen LungMAP team with SCRI colleagues! @nebanovich.bsky.social @jensucre.bsky.social

Single-cell profiling demonstrates the combined effect of wheeze phenotype and infant viral infection on airway epithelial development Airway epithelial cells from children with wheeze are characterized by altered development and susceptibility to RSV infection.

Congratulations to Serges, Dawn, Tina and team! Single-cell insights into how early life RSV infection contributes to asthma risk.

www.science.org/doi/10.1126/...

Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules | NEJM Each year, millions of pulmonary nodules are identified incidentally or through lung cancer screening, and many involve biopsy to distinguish cancer from benign processes. Both navigational broncho...

Congratulations to our amazing IP colleagues - really important paper addressing approach to diagnosis of pulmonary nodules out in NEJM- www.nejm.org/doi/full/10....

This is definitely worth a read... This is what conscience and courage look like...

www.atsjournals.org/doi/10.1513/...

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So excited that our study made the cover of Nature Genetics this month!

the yield on NIH research for economic activity

How to get 146% return on investment?
The NIH. That's just the economic benefit.
Biomedical research promotes human health.

ROI on NIH funded research has been consistently calculated at $2-3 per dollar of grant awards - NIH support for biomedical research is both highly impactful for scientific progress and a high-yield investment

Great to see this out - and thanks also due to our reviewers - this paper is much improved from preprint version thanks to their feedback - great work Annika, Ruqian and rest of team!