Brian Sheridan Lab

We gave Jay Bhattacharya an opportunity to clarify his vaccine stance: does he REALLY believe that the vaccine is worse than the disease? Instead, he launched into a defense of MAHA as the future of scientific inquiry, and never really gave us a straight answer...

@repauchincloss.bsky.social

Chimeric MHC class I and II-restricted non-self epitopes broaden anti-tumor T cell reactions. New study from Rongsheng Zhang, Tasuku Honjo, Kenji Chamoto and colleagues @ccii-kyoto.bsky.social: rupress.org/jem/article/...

#TumorImmunology

Review: Reaching maturity: Thymic γδ T cell differentiation in mice and humans
www.science.org/doi/10.1126/... @sciimmunology.bsky.social @bsilvasantos.bsky.social

Urs Mörbe, William Agace et al. characterize and spatially map the fibroblast landscape within human large and small intestinal gut-associated lymphoid tissues, including Peyer’s patches and isolated lymphoid follicles, during homeostasis and #Crohns disease. rupress.org/jem/article/...

#IBD

Support a New York State Biomedical Institute for a Healthier, More Affordable Future Can you spare a minute to help this campaign?

Always worth repeating: Every new medicine begins in an academic lab, and this publicly funded research is one of the strongest economic engines a state can support, making the proposed EBRI a win-win for everyone, so sign and share >>> c.org/nDnRNSsVcq

All my top music is from grant writing 😱

Hey friends. I’m looking for a postdoc interested in studying host-pathogen interactions and immunology of tuberculosis. Send me some good people! We have a great group here! Email me joanne@pitt.edu. Thanks!

Immunologists Push for State Biomedical Research Funding in New York - AAI News Dr. Shruti Naik is one of the immunologists in New York state behind NY-CURES, advocating for state investment in biomedical research.

Wondering why you should ✍ our petition? c.org/nDnRNSsVcq

In @aai.org, founder @drshrutinaik.bsky.social reveals why the coalition was formed, why NY needs a state-backed research institute, and how scientists should organize for systemic support — here and nationwide.
news.aai.org/2025/11/20/n...

David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS Nature - The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.

David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS

The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.

Why we have to continue with animal testing for medical research | Letters Letters: Dr Robin Lovell-Badge and Prof Emma Robinson respond to an editorial on using new technologies to reduce the reliance on animal experiments

Key points on the need for continued animal use in scientific research. www.theguardian.com/science/2025...

Sign the Petition Support a New York State Biomedical Institute for a Healthier, More Affordable Future

Run a lab? Work in a lab? Wondering where your future research funding will come from?

New York has an unprecedented opportunity on the table — a bold proposal to supercharge biomedical research and innovation across the state.

👉 Sign the petition & share to help make it happen.: c.org/TDMy2H9JTW

Human lung CD8+ tissue-resident memory T cell-derived interferon-γ orchestrates subset-specific antiviral programming in airway epithelial cells Mattingly et al. use human lung cells to show that virus-specific CD8+ tissue-resident memory T cells trigger epithelial antiviral defenses via IFNγ. This early protective response varies by epithelial subset, restricts influenza infection, and highlights the importance of Trm-epithelial cell crosstalk in mediating respiratory virus control.

Online now: Human lung CD8+ tissue-resident memory T cell-derived interferon-γ orchestrates subset-specific antiviral programming in airway epithelial cells

Excited to share our new paper in
@jem.org! 🎉
We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (#Trm) amplify antiviral protection during reinfection. #immuno
🧵👇1/6

From MRI to Ozempic: breakthroughs that show why fundamental research must be protected In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake

go.nature.com/47zrzYZ

Enjoyed sharing my home brew 'Cyto-hops-ic IE-ale' with everyone at our departmental Oktoberfest. Unfortunately, only my lab and a select few understood the reference.

Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...

www.nejm.org/doi/10.1056/...

Science is pretty amazing! The amount of basic science that leads to these clinical breakthroughs is staggering and often not appreciated by the politicians that decide funding levels

I'll take #gdTcells for $500

US senators poised to reject Trump’s proposed massive science cuts Committee gives first hint that policymakers might preserve, rather than slash, funding for US National Science Foundation and other agencies.

A key US Senate committee has indicated that it will reject the huge budget cuts that President Donald Trump proposed for some science agencies, including the US National Science Foundation and NASA.

go.nature.com/40H0XST

As NIH budget deliberations continue, prepare to hear Bhattacharya deflect substantial questions about the negative effects of his funding policies with “I’m an economist.”

He’s not a very good one if he’s unable to assess the impact of funding decisions at the agency he directs.

Macrophages: sentinels, warriors, and healers Abstract. Macrophages are versatile innate immune cells that act as sentinels, warriors, and healers in virtually every tissue. This review synthesizes cur

Our latest review on macrophages Macrophages: sentinels, warriors, and healers url:https://academic.oup.com/hmg/article-abstract/doi/10.1093/hmg/ddaf087/8158008

academic.oup.com/hmg/advance-...

This is a great idea! I really enjoy the JI Pillar articles

Listen to our newest Immunology faculty @priyadevarajan.bsky.social discussing her new lab @stonybrookmedicine.bsky.social and the benefit of @societymucosalimm.bsky.social mentorship program to her career development!

Plot of life expectancy after Type 1 diabetes diagnosis, 1850-2025. After the discovery of insulin in 1921, life expectancies go gradually from zero to seventy years.

These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.

It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.

Government | Harvard University Browse the latest Government courses from Harvard University.

Proud of Harvard for pushing back, exercising some creativity, and, maybe, helping folks get some needed education.

Harvard is making many of their online government courses FREE.

I just signed up for "Citizen Politics in America".

They even asked me my Gender.

pll.harvard.edu/subject/gove...

Metabolic reprogramming of IL-17 producing gd T cells promotes de novo lipogenesis under psoriasis conditions

NEW: We (mostly @noamross.net) launched a website to shine a brighter light on terminated NIH and NSF grants.

grant-watch.us

It links to our NIH & NSF trackers, grant info submission forms, and other info. We'll also add new analyses soon.

Check it out and let us know what else you'd like to see.

Biomedical Research: Keeping America’s Edge in Innovation | United States Senate Committee on Appropriations United States Senate Committee on Appropriations

www.appropriations.senate.gov/hearings/bio...

Check out this cool new study from a colleague at @stonybrookmedicine.bsky.social. Congrats to Charles and his team! Mtb-reactive CD8a expressing NK cells in humans!

Another great study from the @khannakm.bsky.social lab! Disease tolerance to limit Pathology in mucosal tissues