Mahsa Dadar

Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI https://www.medrxiv.org/content/10.1101/2024.05.15.24307354v1 Numerous research groups worldwide have focused on postmortem imaging to bridge the resolution gap b

Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI https://www.medrxiv.org/content/10.1101/2024.05.15.24307354v1

Postmortem MRI of Tissue Frozen at Autopsy https://www.biorxiv.org/content/10.1101/2024.01.20.576456v1 Introduction: Postmortem MRI provides insight into location of pathology within tissue blocks, enabl

Postmortem MRI of Tissue Frozen at Autopsy https://www.biorxiv.org/content/10.1101/2024.01.20.576456v1

Effects of Postmortem Intervals on Quantitative MRI in Unfixed and Fixed Swine Brain: Implications for Ex Vivo MRI Applications https://www.biorxiv.org/content/10.1101/2025.10.08.681281v1

Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II https://www.biorxiv.org/content/10.1101/2025.11.21.689744v1

Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease - Nature Medicine In cognitively normal older adults at risk for Alzheimer’s dementia, physical inactivity was associated with faster tau protein buildup and cognitive decline.

Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease www.nature.com/articles/s41... via @natmed.nature.com

#Alzheimers #dementia #publichealth #exercise #fitness #geriatrics #GeriSky

We are excited to launch The Data Quartet Challenge, recognizing student contributions to projects that integrate data from at least 2 of 4 FRQ supported Quebec Alzheimer’s and Aging cohorts (PREVENT-AD, CIMA-Q, NuAge, TRIAD), with 3 prizes of 5000$ tinyurl.com/3dy899xn

Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan | doi.org/10.1371/jour...

How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates @plosbiology.org ⤵️

Integrating and interpreting brain maps | doi.org/10.1016/j.ti...

Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️

Hey #AAIC25 !
Today I'll be sharing our research on the mediating effect of WMH on spontaneous brain activity during aging! 🧠
Join me on poster 430!
@ameliemetz.bsky.social @dadarmahsa.bsky.social @yasharneuro.bsky.social @roqamoqa.bsky.social

🧾 Poster #487
Data-Driven Characterization of Heterogeneous Brain Atrophy and White Matter Hyperintensity Progression in FTD (Amelie Metz @ameliemetz.bsky.social )
Tuesday, July 29

Honoured to have been awarded the Vanier Scholarship — pretty psyched about it. Big thanks to everyone who’s helped me get here!

In vivo and in silico alpha-synuclein propagation dynamics: The role of genotype, epicentre, and connectivity Synucleinopathies, like Parkinson's disease (PD) are characterized by progressive accumulation and spread of misfolded alpha-synuclein (aSyn) throughout the brain. To improve understanding of disease ...

Really excited to share this new preprint on the dynamics of alpha-synuclein spreading by Dr. Stephanie Tullo in our group. This was a long term labour of love spanning the pandemic, experimental work, and in silico modelling

www.biorxiv.org/content/10.1...

See more below ⬇️

REC Scholar Events at AAIC 2025 July 27, 2025, 12:15-2:00pmET: ADRC Early Career Networking Luncheon, Metro Toronto Convention Centre Room 808 July 30, 2025, 6:30-8:30pmET: ADRC REC Scholar Reception, Delta Hotel, Parkdale Room (3rd Floor)

The REC Steering Committee is excited to host multiple opportunities for early career researchers across the #NIAfundedADRC Program to gather at #AAIC2025!

RSVP to connect w/other scholars and leaders from #NIA, #NINDS, and the ADRC Program: uwashington.qualtrics.com/jfe/form/SV_...

In @ohbmossig.bsky.social's first Open Datasets Special Issue paper, Wearn et al. introduce the OHBM Time Machine, a freely accessible archive of Annual Meeting content on YouTube: doi.org/10.52294/001...

@alfiewearn.bsky.social @sitek.bsky.social @sofievalk.bsky.social @stephforkel.bsky.social

wonderful opportunity for junior faculty

🚨New preprint 🚨
TL;DR Supporting cerebrovascular and mental health, along with staying cognitively engaged, may help preserve brain function and delay cognitive decline and dementia.
@dzne.science

Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative e...

After 3 years of "just one more analysis", our work on WMH pathophysiology is finally out!

Building on previous post-mortem findings of non-vascular WMHs, we identified a specific signature of neurodegenerative WMHs in vivo using microstructural MRI and normative modeling

doi.org/10.1101/2025...

Sex Differences in Vulnerability to Tau Pathology: Impact on Cognitive Decline https://www.medrxiv.org/content/10.1101/2025.05.25.25328324v1

Gray matter microstructure from in-vivo diffusion MRI reflects post-mortem neuropathology severity and clinical progression of Alzheimer's disease https://www.medrxiv.org/content/10.1101/2025.05.30.25328630v1

Vascular risk factors mediate the relationship between education and white matter hyperintensities https://www.medrxiv.org/content/10.1101/2025.06.03.25328899v1

Thanks Mallar! :)

Happy to see my first first-author paper in Imaging Neuroscience (along with @fmrib-karla.bsky.social and @nichols.bsky.social):

Characterising ongoing brain aging and baseline effects from cross-sectional data

doi.org/10.1162/IMAG...

Parkinson's disease links to ultra-processed foods and pesticides
www.nytimes.com/2025/05/07/w...

www.nytimes.com/2025/05/07/w...

jamanetwork.com/journals/jam...

Chemical additives in plastics (phthalates) and cardiovascular mortality
www.thelancet.com/journals/ebi...

Our Department of Global and Public Health within McGill University School of Population and Global Health is recruiting an Assistant Professor (Tenure Track).

Apply now! 👇

mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Blood pressure reduction and all-cause dementia in people with uncontrolled hypertension: an open-label, blinded-endpoint, cluster-randomized trial - Nature Medicine In the CRHCP-3 cluster-randomized trial, blood pressure reduction lowered the risk of all-cause dementia by 15% in 33,995 individuals with hypertension.

Reducing the risk of all-cause dementia with intensive blood pressure control, the results of a cluster randomized trial in~34,000 participants. @naturemedicine.bsky.social
www.nature.com/articles/s41...

Hey #ADPD2025 , I'm happy to present our work on characterizing brain atrophy and cerebrovascular pathology in Frontotemporal Dementia subtypes!

Tomorrow, April 5, 9:40am, Hall F2, session: Mechanisms and Clinical Trials in FTD, ALS, and Neurodegeneration 02

There's a stream of excellent papers in @apertureohbm.bsky.social being published!

Check them out: apertureneuro.org

Submit your own
+code
+data
+open science
+imaging studies+

Quick turnaround, a devoted ed board, and lowest APC around.

And you'll support @ohbmofficial.bsky.social

share pls!

Metz et al. report that a study combining MRI brain atrophy and clinical data using machine learning achieved 89% accuracy in classifying frontotemporal dementia subtypes. Please read at:https://buff.ly/uGmX2fg @DadarMahsa @YasharZeighami @sylv_villeneuve @sducharme66

😋
@dadarmahsa.bsky.social @yasharneuro.bsky.social @sylviavilleneuve.bsky.social