Cameron McAlpine

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

www.nature.com/articles/s41...

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky

What happens in Vagus🎰... find out on July 29th at 10am when you join host Dr. Sarah Stanley as she welcomes University of Virginia's Dr. John Campbell @augcsoup.bsky.social to the #BrainBodyResearchInstitute Seminar Series @mountsinainyc.bsky.social. Register👉 mountsinai.zoom.us/webinar/regi...

Very much looking forward to having Tim as a colleague and lab neighbor! Many exciting collaborations to come!

Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia - Nature Immunology McGavern and colleagues identified a CD8+ T cell population that expresses GZMK in ʽtau-richʼ brains, where it may play a protective role against neurodegeneration.

Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia
www.nature.com/articles/s41...

We are proud to announce that five CVRI faculty members - Fil Swirski (@filswirski.bsky.social), Mandy van Leent, Cameron McAlpine (@mcalpinelab.bsky.social), Maria Noval, and Sikander Hayat - will be presenting their groundbreaking work at Atherosclerosis GRC this Friday, June 27th.

Check out our review on neural mechanisms in cardiovascular health and disease! 👇

A wonderful perspective that includes the idea of cardiovascular disease as a stressor that induces sleep.

We are looking for a scientist to join the growing Brain-Body Research Institute at Mount Sinai! Consider joining a dynamic fundamental and translational team investigating inter-organ physiology and communication between the brain and periphery. Feel free to reach out if you have any questions.

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...

Exciting news! 🎉

Matthias Nahrendorf, MD, PhD, has been named Editor-in-Chief of #JACCBTS! A leader in CV research, imaging & immunology, he brings a passion for collaboration & scientific excellence.

Please join us in welcoming him to this important role 👏👏 👏

📎: www.jacc.org/announcement...

Cold memories control whole-body thermoregulatory responses - Nature Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed betw...

Very excited to share part of my postdoctoral work from the @tjryan.bsky.social lab, out now in @nature.com. Here, my brilliant co-author @andreamunozz.bsky.social and I explored the link between memory engrams and whole-body metabolism.

A thread: 🧵

www.nature.com/articles/s41...

Myelopoiesis is temporally dynamic and is regulated by lifestyle to modify multiple sclerosis - Nature Communications Myeloid cells contribute to the etiology of multiple sclerosis (MS), but the dynamics of myelopoiesis during disease progression is still unclear. Here the authors show, in both mouse models and clini...

We are thrilled to share the latest from the lab! We demonstrate that multi-organ MCSF-dependent myelopoiesis is dynamic in MS and is manipulated by lifestyle to influence disease severity and neuroinflammation. Big congrats to the whole team!
www.nature.com/articles/s41...

Excited to announce an official scientific statement from the @americanheart.bsky.social!

"Multidimensional Sleep Health: Definitions and Implications for Cardiometabolic Health"

Special thanks to @m-pst-ongephd.bsky.social

www.ahajournals.org/doi/10.1161/...

A Huge Congratulations to @scottrussophd.bsky.social 👉 named Director of the NEW #BrainBody Research Institute. The Institute will focus on holistic approaches to science & medicine to gain a better understanding of how the brain & body interact in health & disease. Again, Congratulations Scott!👏💯

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social

Sleep and Long-Term Risk of Type 2 Diabetes in Women With Gestational Diabetes This cohort study assesses whether sleep duration and quality are associated with incidence of type 2 diabetes among women with a history of gestational diabetes who participated in the Nurses’ Health...

Sleep duration/timing and glucose regulation in over 1100 people with 14-day continuous glucose sensor
jamanetwork.com/journals/jam...

Impact of sleep deprivation on monocyte subclasses and function Abstract. The relationship between sleep deprivation, obesity, and systemic inflammation is a critical area of investigation due to its significant impact

Better sleep quality could reduce inflammation and improve health outcomes in obesity
doi.org/10.1093/jimm...
@jimmunol.bsky.social

A crucial role for the cortical amygdala in shaping social encounters - Nature The posterolateral cortical amygdala and other connected brain regions have a key role in mediating the transition from investigative to aggressive behaviour in male mice.

1/4 I am very pleased to share this new manuscript, “A crucial role for the cortical amygdala in
shaping social encounters”, led by 2 spectacular postdocs, Dr. Tony Aubry who is on the job market, and coauthor @neuromanonyc.bsky.social

Read it here: www.nature.com/articles/s41...

Check out this beautiful image called "Sleepy Aorta" from Jake, a student in the lab! This is an immunofluorescent image of atherosclerosis in the aortic root of a mouse with poor sleep. Give the post a ❤️ to vote for the #ArtoftheBrain contest! ❤️↔️🧠

Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

In medical school in the 1980s, we were taught that depression was an unpleasant and unwanted side effect of having a heart attack. But what if it is a healthy physiological response to help you heal by lowering demand on your heart? www.nature.com/articles/s41... | @natureportfolio.bsky.social

How sleep leads to healing after heart attack Scientists found that after heart injury, immune cells called monocytes travel to the brain and trigger a deep sleep that promotes recovery in both mice and people.

www.nih.gov/news-events/...

Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

Sleeping is one of my fav activities. Very excited that we got to share this study by @mcalpinelab.bsky.social showing that cardiac inflammation after a heart attack dictates sleep patterns and promotes healing/recovery.

www.nature.com/articles/s41...

Join us for this exciting seminar!

Join us for this exciting seminar!

PRESS RELEASE 👉 New research by the Icahn School of Medicine at Mount Sinai's Pacific Huynh, @mcalpinelab.bsky.social, et al. first to demo how heart & brain communicate w/ each other thru immune system to promote sleep & recovery after major cardiovascular event👉 www.mountsinai.org/about/newsro...

Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

Myocardial infarction augments sleep to limit cardiac inflammation and damage
- Pacific Huynh, Jan Hoffmann, Teresa Gerhardt, Panos Roussos, Filip Swirski, @mcalpinelab.bsky.social, et al.

OUT NOW in Nature | @natureportfolio.bsky.social
www.nature.com/articles/s41...

Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

We are delighted to share our latest findings in @natureportfolio.bsky.social! We describe cardiogenic regulation of sleep after cardiac injury.

www.nature.com/articles/s41...