ImmunoHorizons

Volume 9 Issue SI | ImmunoHorizons | Oxford Academic ImmunoHorizons is a fully open-access peer-reviewed journal committed to advancing the knowledge of immunology and immunology education.

#ICYMI ImmunoHorizons is excited to share a Special Collection focused on avian influenza, featuring 3 reviews on factors impacting emergence and spread #OneHealth, characteristics of current H5N1 strains, and a method for vaccine design. Read more: ow.ly/6HN550XSZop.

Rapid decline of SARS-CoV-2–specific salivary IgA antibody levels in people with hybrid immunity—data from the STOPCoV study Abstract. Hybrid immune individuals who experience an infection after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine series sh

When comparing salivary IgA antibody levels in those with vaccine-only vs vaccine-and-infection immunity, researchers found that IgA levels to spike and RBD are high in those with hybrid immunity but low in those with vaccine-only immunity. Read more: ow.ly/Xg8W50XNcci.

Are you passionate about immunology and ready to gain hands-on advocacy experience? The AAI PPFP 2026-27 is about more than understanding science policy—it's about making scientists heard. https://www.aai.org/Public-Affairs/PPFP?utm_source=bsky&utm_medium=social&utm_campaign=PPFP_2026#gsc.tab=0.

Exciting Breakthroughs in Pancreatic Cancer Research - Immunology Explained From vaccines that prevent pancreatic cancer entirely to treatments that shrink tumors and make surgery more successful, major breakthroughs are happening in pancreatic cancer research.

AAI Member Dr. Elizabeth Jaffee from Johns Hopkins Medicine shared with #ImmunologyExplained the powerful story of how her research is changing outcomes for patients with pancreatic cancer. Learn more and watch the video: ow.ly/mKx550XyhEC.

Detection of pre-existing immunity to bacterial Cas9 proteins in people with cystic fibrosis Abstract. Cystic fibrosis (CF) is caused by homozygous mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in multi

Researchers sought to determine if pre-existing immunity to Cas9 from S. aureus or S. pyogenes was present or augmented in people with cystic fibrosis (CF), as a cure for #CF will likely require a gene therapy approach. Learn more in ImmunoHorizons: ow.ly/9MUj50XsYlK.

Tumor cells upregulate CCL22 in a STING-dependent manner in response to paracrine factors released by STING-activated myeloid cells and type I interferons Abstract. Immunosuppressive elements within the tumor microenvironment include both regulatory T cells (Tregs) and M2 macrophages. A well-described mechani

Researchers found that exogenous type I interferons, a major downstream product of STING activation, also upregulate CCL22 in cancer cells via a STING-dependent mechanism and that exogenous IFN-β can directly activate STING. Learn more in ImmunoHorizons: ow.ly/C11i50Xmw7h

LIGHT in combination with IL-13 or IL-17 drives inflammatory transcriptional signatures in human pulmonary fibroblasts relevant for human lung disease Abstract. Fibroblasts are structural cells primarily involved in tissue remodeling, but recent single-cell RNA sequencing (RNA-seq) transcriptomic data hav

The synergistic activity of LIGHT with other classical cytokines was observed to regulate transcription in pulmonary fibroblasts and suggests the involvement of LIGHT in shaping fibroblast phenotypes observed in chronic lung disease.

🔗 ow.ly/pGOn50Xmwlq.

#OpenAccess

STING agonists differentially upregulate CCL22 and IFNβ. HeLa (A–D) and MCF7 cells (E–H) were treated with 30 μM of each indicated STING agonist or DMSO vehicle control (for diABZI) for 24 hours, then harvested in TRIzol for RNA purification and RT-qPCR using TaqMan assays for CCL22 or IFNβ. Error bars represent SDs of independent biological replicates. Statistical analyses were performed on log-transformed data using unpaired, 2-tailed t tests except for (C) and (G), which were analyzed with a one-way ANOVA and Šídák multiple comparisons test. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001; ns, not significant.

Researchers found that exogenous type I interferons, a major downstream product of STING activation, also upregulate CCL22 in cancer cells via a STING-dependent mechanism and that exogenous IFN-β can directly activate STING. Learn more in ImmunoHorizons: ow.ly/C11i50Xmw7h

🎃 Happy Halloween! Ever wondered what your immune cells would wear to a costume party?
🚑 Neutrophil as an EMT: First responder on duty!
🥷 Killer T-Cell as a K-Pop Demon Hunter: Eliminating threats with precision!
What do you think each immune cell would wear for Halloween?

Zombie Ants, Spider Bait, and a Sneaky Burrowing Worm: The 6 Spookiest Science Discoveries of the Past Year The natural world is full of discoveries that feel straight out of a Tim Burton fever dream.

#DYK We published one of the 6 spookiest discoveries of the year according to @zmescience.bsky.social? As a ghost passes through a wall, the parasitic work Schistosoma mansoni can pass through your skin without being detected. Read more: ow.ly/yIUS50Xl7h3.

📘 ow.ly/189i50Xl7h4

CHPE and metformin can modulate immune responses and improve gland function in mouse model of Sjögren’s disease via interaction with antigen-binding grooves of MHC Class II, with effectiveness varying by sex and age
academic.oup.com/immunohorizo... @immunohorizons.bsky.social

YouTube video by The American Association of Immunologists (AAI) Join us for IMMUNOLOGY2026™

Get ready for #IMMUNOLOGY2026™! We're heading to the vibrant city of Boston, MA. Prepare for groundbreaking science, incredible networking, and an unforgettable experience. Don't miss your chance to be part of the #immunology community! Learn more: immunology2026.aai.org/abstracts.

🚀 New from AAI: Immunology Explained — a hub for clear, evidence-based insights into how the immune system protects health.

Check it out: immunologyexplained.aai.org
Find and follow Immunology Explained on TikTok, Facebook, Instagram and YouTube
#ImmunologyExplained

Graphic reading AAI WEBINAR: How to Be the Reviewer You Want to Have featuring a headshot of Dr. Gail A. Bishop, EIC of The Journal of Immunology.

An essential conversation during #PeerReviewWeek! We hosted the webinar "How to Be the Reviewer You Want to Have," presented by Dr. Gail A. Bishop, EIC of @jimmunol.bsky.social.
It's a key topic for graduate students and post-docs. Watch now: ow.ly/mAXQ50WZ1kH #TBT #PeerReviewWeek

Boost your career with an AAI Travel Award! Open to AAI members, these awards provide funding to attend #IMMUNOLOGY2026™. Submit your abstract and apply for an AAI Travel Award by the October 15 deadline. Learn more: ow.ly/cBuc50WYhwq.

Joining us on Capitol Hill Sept 30? Meet our exciting lineup of speakers: Dr. James Allison, world-renowned oncology expert, Dr. Elizabeth Jaffee, and cancer survivor Alexis Browning. They will share their expertise and insights on the impact of immunotherapy. RSVP today: bit.ly/AAI-GA-Brief....

Review @immunohorizons.bsky.social
The cat’s out of the bag: Toxoplasma gondii provides further insight into myeloid-mediated host defense
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Dynamics of antimicrobial proteins’ expression and their bactericidal activity in mouse milk Abstract. Mother’s milk is considered as “complete edible immune system.” It contains macro- and micronutrients required to maintain infant growth and prov

New findings provide insight into the dynamics of various immune proteins present in breastmilk and highlight their pivotal roles in determining neonatal immune responses and microbial colonization at early stage. Read all about it: ow.ly/tGcu50W0eG3. #OpenAccess

🚨 IMMUNOLOGY2026™ abstract submissions are now open! Share your groundbreaking research with the global immunology community. Submit your abstract by October 15: immunology2026.aai.org/abstracts

The latest press release for @immunohorizons.bsky.social showcases new research that paves the way for more personalized veterinary care for dogs that could help dog owners make informed decisions that keep their pets healthier longer. Read it in #AAInews: ow.ly/imSg50WMatf.

Graphic of AAI Webinar that reads Biomarker Selection and Analysis in Clinical Trials with headshots of Allan D. Kirk and Katherine P. Liao.

🔬 Join us for a webinar on Biomarker Selection and Analysis in Clinical Trials on Sept 2, 4-5 PM ET! Featuring Drs. Allan D. Kirk (@dukehealth.bsky.social) and Katherine P. Liao (@harvardmed.bsky.social). Don't miss out and register now: ow.ly/zAOG50WHPy8 #AAIwebinar #clinicalimmunology #immunosky

Aberrant humoral immune responses and intestinal homeostasis in Cd38 Bst1 double knockout mice
@immunohorizons.bsky.social
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The countdown begins to #IMMUNOLOGY2026™ in Boston, MA! In less than two weeks, you can submit your abstract from September 3 – October 15. Start preparing your research today for a chance to present in Boston! immunology2026.aai.org

#immunology #scicomm

Is your lab at risk due to unexpected federal grant terminations? The AAI RESTORE Grants Program offers up to $100K to help you retain personnel & continue critical immunology research. Deadline Aug 28! Share with your colleagues today: ow.ly/4PWF50WxYt4.
#ScienceFundingCrisis #SupportResearchers

A parasitic worm suppresses neurons to evade detection. Researchers from @tulanemedicine.bsky.social say isolating the molecules responsible for the suppression could lead to new painkillers for humans. Read more in the latest press release on AAI News: ow.ly/Agot50WCM2E.

Researchers discovered B cell follicles in nurse shark pancreas and saw antigen-specific antibodies were produced in the pancreas following immunization providing insight into how immune surveillance may function in the absence of lymph nodes. Read more: ow.ly/oF6q50WCKbg

🚨 AAI is proud to announce the launch of the AAI RESTORE Grants Program, an $8M emergency funding initiative to support scientists whose immunology-focused federal research grants were abruptly terminated or frozen in 2025.

🔗 ow.ly/rwMU50Wy3Mp

#AAIRESTORE

Apply today to participate in the AAI Peer-Review Mentorship Program! This program is designed to provide mentorship from seasoned professionals to develop your skills as a peer reviewer of manuscripts submitted to AAI journals. Learn more: ow.ly/qLyn50WuPxA.

Characterization of extensive diversity in immunoglobulin light chain variable germline genes across biomedically important mouse strains
@immunohorizons.bsky.social
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Efficacy and safety of acalabrutinib with best supportive care versus best supportive care in patients with COVID-19 requiring hospitalization Abstract. The efficacy and safety of acalabrutinib, a Bruton tyrosine kinase (BTK) inhibitor, was evaluated in 2 phase 2 studies in hospitalized patients w

@astra-zeneca.bsky.social evaluated acalabrutinib with supportive care vs. supportive care alone in phase 2 clinical studies of hospitalized patients with #COVID19. No safety concerns and no significant benefit of adding acalabrutinib were reported. Read more in IH: ow.ly/gxE250Wa1fS.