Bach Nguyen

Radical S-Adenosyl-l-Methionine Oxygenase DarE Forms Ether Bond via a Partially Delocalized Tryptophan Cβ Radical Darobactins are ribosomally synthesized and post-translationally modified peptides (RiPPs) with potent activity against Gram-negative pathogens. Their antibiotic function depends on a distinctive β-st...

My second JACS paper from my PhD is now published! In collaboration with @melissabollmeyer.bsky.social in Dave Britt’s lab at UC Davis and Smirnov lab at NC State, we trapped a radical intermediate in radical SAM oxygenase DarE during darobactin biosynthesis.

pubs.acs.org/doi/10.1021/...