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TGen

@tgenresearch.bsky.social

A nonprofit institute, translating genomic research into life changing results. TGen is part of City of Hope. Follows & likes are not an endorsement.

80 Followers  |  6 Following  |  40 Posts  |  Joined: 18.11.2024  |  1.7602

Latest posts by tgenresearch.bsky.social on Bluesky

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Congratulations to TGen - Part of City of Hope clinical professor, Vinodh Narayanan, M.D., on receiving the Roger and Mary Brumback Lifetime Achievement Award at the 2025 Child Neurology Society Meeting.

Photo credit: Keri Ramsey

28.10.2025 22:27 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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@tgenresearch.bsky.social partners to release new technology with @googleresearch.bsky.social and @ucscgenomics.bsky.social: DeepSomatic πŸ§‘πŸ½β€πŸ’» This #machinelearning method is a major leap forward for #cancer mutation #detection. More at bit.ly/4nYDDJY and lnkd.in/gQA4frVa
#Research #Genomics

23.10.2025 21:32 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1
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Great presentations from the lab this week at #ashg25.

17.10.2025 20:36 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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For #postdoc appreciation week, we sat down with Dr. Aya Kamzinain the Division of Early Detection and Prevention at TGen, to learn more about her work and role as a postdoc. Full blog at bit.ly/48jnkT6
#Science #Research #Impact #Thoughtleader #Genomics #foryoupage #fyp

16.09.2025 17:00 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Interesting @nebanovich.bsky.social @florisbarthel.bsky.social glad we just installed an @elembio.bsky.social Aviti24 @tgenresearch.bsky.social. @aphillippy.bsky.social is this with standard cloudbreak chemistry or the high accuracy ultraQ chemistry

06.09.2025 19:15 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Researchers have identified 2 proteins that could serve as new biomarkers for #pancreatic #cancer. These protein markers can help distinguish cancer from non-cancer and track how patients are responding to treatment. This offers a new direction for the early detection & monitoring. bit.ly/4mbboX0

08.09.2025 20:10 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Yesterday was the last day of @tgenresearch.bsky.social's summer internship supported by the Helios foundation. Bittersweet to say goodbye but happy to see them presenting their great work. Special congrats to Francesca, Lauren, and Yafnelt who were recognized for their outstanding presentations.

01.08.2025 21:38 β€” πŸ‘ 8    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Frontiers | NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer IntroductionImmune-based agents, especially Immune Checkpoint Inhibitors (ICI), are standard of care therapy in non-small cell lung cancers (NSCLC); however,...

Full journal article at bit.ly/4mdoljt

25.07.2025 15:24 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Breakthrough news in the fight against lung cancer! 🚨 A new study shows how molecules from a patient's own immune cells (natural killer cells) could reawaken the body's defenses to combat tough tumors for hard-to-treat lung cancers; harnessing the body's own natural killer cells to fight back.

25.07.2025 15:24 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Building the evidence base for engaging all populations in genomics research is key for Participant Engagement and Cancer Genome Sequencing Network (PE-CGS). The newest paper introduces a new framework & strategies for involving community members in #cancer #genomics #research. lnkd.in/gjj-WQ8n

11.07.2025 17:59 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

But not all mutations block all anti-BCMA therapies from binding and we at @tgenresearch.bsky.social and @cityofhope.bsky.social are integrating the known binding of these agents into our whole genome sequencing reports to ensure patients get the therapy that will work best for them at that point

03.07.2025 16:49 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Long-Term (β‰₯5-Year) Remission and Survival After Treatment With Ciltacabtagene Autoleucel in CARTITUDE-1 Patients With Relapsed/Refractory Multiple Myeloma CARTITUDE-1 evaluated ciltacabtagene autoleucel (cilta-cel) in patients with heavily pretreated relapsed/refractory multiple myeloma (RRMM). We describe overall survival (OS), β‰₯5-year progression-free...

ascopubs.org/doi/10.1200/... considering the patient population this is extremely impressive, 1/3 of patients progression free at 5 years, glad to have @cityofhope.bsky.social physician Dr. Myo Htut as one of the coauthors. I for one believe cures are possible in #myeloma @tgenresearch.bsky.social

07.06.2025 17:38 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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TGen scientists have found a new weakness in a rare ovarian cancer that might help us treat it better. This could mean new and improved treatments are on the way, even for cancers that were hard to treat before. More at www.tgen.org/news/study-r.... #OvarianCancer #Research

23.05.2025 16:11 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

2/2This study is a big step towards:
πŸ’‘ Understanding liver disease better, especially in people who might not seem at risk
πŸ” Catching problems earlier and helps prevent serious health problems in the future - Such as Liver Cancer, Liver Failure, Cirrhosis, and other related diseases like diabetes.

22.05.2025 20:42 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Liver disease can affect anyone, not just those who are overweight πŸ€” A Study found that even healthy-weight people can have fat in their liver, & it might be because of their genes. Learning about these genes can help doctors figure out who's at risk & improve care for everyone.
bit.ly/3YURmas

22.05.2025 20:42 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Where science meets business🀝An insider’s perspective on how today’s #biomedical research translates into tomorrow's treatments. Stephanie Pond, Ph.D., shared how her team works to identify gaps in current research tools, & help commercialize TGen’s research discoveries. Listen todayπŸŽ™οΈ bit.ly/3YYzjzU

19.05.2025 21:01 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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4️⃣ things #emerging #scientists should do as they prepare for a role in research. Ignazio S Piras, Ph.D., shares tips for preparing for a world in research, and how having a unique educational background has allowed him to participate in a wide variety of projects.
www.linkedin.com/.../world-wi...

12.05.2025 15:56 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Congratulations to Daniel D. Von Hoff, M.D., F.A.C.P., distinguished professor at TGen and @cityofhope.bsky.social, on being recognized at the #AACR25 Partners in Progress Reception for his immeasurable contributions to AACR, cancer research and patient care!

28.04.2025 17:19 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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🧬 Today is National DNA Day 🧬
We wouldn't be where we are today without the hard work of Friedrich Miescher (1869) and Rosalind Franklin, James Watson, and Francis Crick (1953). Thanks to their contributions, the foundation of genetics and genomic sciences is strong.

25.04.2025 15:59 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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TGen is proud to present at the 2025 @theaacr.bsky.social Annual Meeting.

Be sure to stop by the @cityofhope.bsky.social and TGen booth at the Exhibit Hall from April 27 - 30.

#AACR25 #Cancer #Research

23.04.2025 16:30 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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πŸ’‘Remarkable ResearchπŸ’‘The #MindCrowd mobile lab is a unique research project bringing the lab to the community. Research can be scary & hard to find the time to participate, so the MindCrowd team goes to communities allowing individuals to be a part of brain research. More at tgen.org/mindcrowd 🧠

18.04.2025 16:24 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Great work on whole genome assembly using @nanoporetech.com and @pacbio.bsky.social sequencing @tgenresearch.bsky.social part of @cityofhope.bsky.social

17.04.2025 03:05 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Navigating the Frontiers of Science: A Journey in Computational Biology with Heini Natri Author – TGen Heini M. Natri, Ph.

www.linkedin.com/pulse/naviga...

#Science #Research #Impact #Technology #ComputationalScientist #Genomics #Collaboration #TGen #CityofHope

14.04.2025 19:46 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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πŸ’‘ "Good researchers and leaders figure out the right questions to ask." πŸ’‘Meet Dr. @heinimnatri.bsky.social, Research Assistant Professor. She shares insights on team science, mentorship, & her recent breakthrough in glioblastoma researchβ€”helping pave the way for new clinical trials in CAR T therapy.

14.04.2025 19:46 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
The TGen Talks Podcast

#PulmonaryFibrosis #LungHealth #Research #TGenTalks #Podcast

11.04.2025 21:32 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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🫁 Pulmonary fibrosis is a devastating disease with no cureβ€”only a lung transplant. But new research from TGen, uncovers hidden disease markers in seemingly healthy lung tissue using advanced spatial transcriptomics.πŸŽ™οΈ TGen Talks w/@nebanovich.bsky.social breaks it down at www.tgen.org/tgen-talks/

11.04.2025 21:32 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Complete sequencing of ape genomes - Nature Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future evol...

FOXO3Bβ€”linked to longevityβ€”is nearly human-specific (only detected in gorilla otherwise). Its unique genomic context near regions tied to neurodevelopment disorders might hint at roles in our cognitive abilities and longevity. #Genomics #Longevity #FOXO3B #Science #fyp #ForYouPage

10.04.2025 16:46 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Complete sequencing of ape genomes - Nature Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future evol...

We’re uncovering clues about what makes us human!

In a recent Nature paper, TGen Drs. Nicholas Schork and Agnes Chan joined Germany’s Dr. Michael Hiller in a study that compared ~20K human genes with six ape genomes using T2T assemblies.

www.nature.com/articles/s41...

10.04.2025 16:46 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

New prepreint alert 🚨 Great work by all the collaborators and shoutout to TGen's @heinimnatri.bsky.social work on this!

03.04.2025 16:06 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Excited to share our new work exploring strategies to overcome resistance to CAR T cell therapy in solid tumors. Using scRNA-seq, mouse models, and functional studies, our work points to SPP1 signaling in the TME as a critical component of this resistance. www.biorxiv.org/content/10.1...

03.04.2025 14:15 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 1    πŸ“Œ 1

@tgenresearch is following 6 prominent accounts