Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understanding the accompanying mechanisms could pave the way for early-stage biomarkers.

Nature research paper: Intestinal macrophages modulate synucleinopathy along the gut–brain axis

go.nature.com/4rg6DOI

04.02.2026 07:48 — 👍 28    🔁 9    💬 0    📌 1

Thanks for sharing @mucosalimmunol.bsky.social. This work was led by @lizihegarty.bsky.social during her PhD @edinuni-irr.bsky.social funded by @wellcometrust.bsky.social. Now being continued after our relocation to @uofgsii.bsky.social.

Might be of interest to @emds2025.bsky.social attendees!

27.11.2025 08:52 — 👍 16    🔁 8    💬 0    📌 0

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair in this work from @lizihegarty.bsky.social, @bainlab.bsky.social, and colleagues: www.mucosalimmunology.org/article/S193...

26.11.2025 16:02 — 👍 22    🔁 8    💬 0    📌 2

Had a great time at #EMIG. Big thanks to the organizers for giving me the opportunity to present my work and for the travel award! Looking forward to the next in Prague!!

24.07.2025 12:46 — 👍 1    🔁 0    💬 0    📌 0