Matt Cooperberg

Re: Rajal B. Shah, Gladell P. Paner, Liang Cheng, et al. Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer: Call for a ...

When #prostatecancer just ain’t cancer.

👀 👇

www.sciencedirect.com/science/arti... Re: Rajal B. Shah et al. Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer: doi.org/10.1016/j.eu...

@dr-coops.bsky.social

Good concise article on the status of Active Surveillance for Prostate Cancer. As treatment/surveillance becomes more precise, Screening becomes more palatable for Primary Care.
via @dr-coops.bsky.social #MensHealth
cuaj.ca/index.php/jo...

Not that I’ve seen nationally. We have a paper from UCSF network hopefully coming soon… our local rates are up quite a bit but still low esp among younger men

Great Q. I’m optimistic. % of low risk disease at dx has fallen to ~20%, and rates of AS for low risk are rising. We’re increasingly able to define—and even implement—smarter screening.

Cancer Statistics 2025 are out! #prostatecancer incidence still on the rise, mortality basically flat. Get screened so you can get treatment _when needed_. #pcsm
acsjournals.onlinelibrary.wiley.com/doi/epdf/10....

Actually, mele kalikimanukkah!

Mele kalikimaka :)

Figure. Time Trends in the Initial Selection of Active Surveillance and Watchful Waiting Among Individuals With Intermediate-Risk Prostate Cancer

Initial active surveillance and watchful waiting significantly increased for intermediate–risk prostate cancer between 2010 and 2020.

https://ja.ma/4042hPZ

Negative Predictive Value of Multiparametric Magnetic Resonance Imaging in the Detection of Clinically Significant Prostate Cancer in the Prostate Imaging Reporting and Data System Era: A Systematic R... : Prebiopsy multiparametric magnetic resonance imaging (mpMRI) is increasingly used in prostate cancer diagnosis. The reported negative predictive val…

I was going by this one:

www.sciencedirect.com/science/arti...

But totally agree 90 is generous in real life

Felix Feng, MD

It is with great sadness that we mourn our cherished friend and colleague Felix Feng, MD. Felix was a distinguished physician-scientist and beloved at @ucsfhealth.bsky.social. His vision, dedication, and commitment inspired colleagues, peers everywhere, and patients. cancer.ucsf.edu/in-memoriam-...

Totally agree. NPV for MRI over many studies is consistently more like ~90% — when read by high volume experts.

MRI pre-biopsy is super helpful, but for a reflex test to r/o bx altogether we have better options that are also (in the US and only in the US) a lot less expensive.

Spotted outside the UMich reception at #SUO24 — thx to Dallas for customizing your neon for the Urology meeting 🤣

After a shocking shooting, Americans vent feelings about health insurance — NPR The death of UnitedHealthcare CEO Brian Thompson triggered a deluge of painful stories about health care denials on social media.

Brian Thompson’s assassination is a horrifying and tragic. But maybe something good will come of this renewed conversation about an industry whose _entire_ business model has been based for decades on profiting at the expense of patients and providers.

apple.news/ASy_o_WGXRI6...

Great updates from Patrick Hensley and Mark Tyson on the huge and growing array of options for non-muscle-invasive #bladdercancer #SUO24

Active Surveillance or Watchful Waiting for Intermediate-Risk Prostate Cancer This cross-sectional study evaluates trends and factors associated with selecting active surveillance or watchful waiting among individuals with intermediate-risk prostate cancer.

How often is AS/WW used in int risk prostate cancer? Leapman et al @yalecancer.bsky.social report in JAMA that AS/WW use increased from 5 - 12.3% from 2010-20, most in GG1 dz. Treat high-risk disease early, but offer AS/WW for low + some int risk cancers. jamanetwork.com/journals/jam...

When is prostate cancer really cancer? - PubMed Prostate cancer (PC) is a major cause of cancer-related deaths worldwide, with far more diagnoses than deaths annually. Recent discussions have challenged whether Grade Group 1 (GG1) PC should be labe...

Pathologists are definitely less enthusiastic but there is a generational effect that specialty too (see the paper).

The arguments are getting stronger. It’s probably just a matter of time…

pubmed.ncbi.nlm.nih.gov/39350309/

Physician Perception of Grade Group 1 Prostate Cancer - PubMed In this study, we found that active surveillance remains underused in the management of low-risk prostate cancer because of incorrect perceptions regarding cancer outcomes. Omitting the word "cancer" ...

Seems to be an area the US is “ahead,” based on polls at SUO, ASCO GU, and this study: pubmed.ncbi.nlm.nih.gov/37117112/

Was there a speaker arguing “Pro”?

Gabe C. on LinkedIn: #prostatecancer Listen to this [Excerpt]. Dr. Matt Cooperberg, MD, MPH is leading a conversation on reclassifying Grade Group 1 #prostatecancer. Some doctors believe renaming…

Or, if you’ve truly abandoned Twitter: www.linkedin.com/posts/gcanal...

It was great to have the chance to chat with @gabecanales.bsky.social last week about low-risk #prostatecancer and active surveillance

x.com/gabecanales/...

@bluecure.bsky.social

OK that’s just nuts. Clearly appeal??

(Btw why 55867 not 55866? Isn’t -67 for robo simple?)

Capping the Chromosome: Elizabeth Blackburn and the Discovery of Telomerase Telomerase is one of those enzymes which just won’t let you come to a settled opinion. When it runs wild, it promotes cancer. But it also protects each and every one of your chromosomes faithfully, ...

Happy 76th birthday to 2009 Nobel Prize recipient Elizabeth Blackburn, whose 1984 discovery of telomerase not only demonstrated that cells can use RNA to construct DNA, but has spawned an entire field of biological study.

tinyurl.com/47zp8azb

#WomenInSTEM
#HistSci
#BioSky
🧪

Whoa! No never ever heard of that. What were these case details?

UCSF Helen Diller Family Comprehensive Cancer Center logo

Good morning! Recommending a number of our early adopters & growing list of #OncSky heavy hitters to follow: @sueyom.bsky.social @andreigoga.bsky.social @dr-coops.bsky.social @drkomanduri.bsky.social @atulbutte.bsky.social @hoperugo.bsky.social @hemedoc.bsky.social and more: bsky.app/profile/did:...

Overtreatment of Prostate Cancer Among Men With Limited Longevity in the Active Surveillance Era This cohort study examines if rates of overtreatment of men with prostate cancer with limited life expectancy have persisted in the active surveillance era and whether overtreatment varies by tumor ri...

jamanetwork.com/journals/jam...

#Overtreatment of #prostatecancer persists, especially using #radiotherapy.

This continues to be the biggest barrier to equitable #populationscreening for #earlydetection.

We must stop doing it.

#activesurveillance @uroweb.bsky.social

Ooooh just think of the visual abstracts these can power! 🙃

Opinion | For now, let’s revel in Bluesky’s promised land and kid ourselves it’ll never get like X — Guardian US Watching the numbers migrate from Elon Musk’s toxic platform is addictive, but the best social media is finite

Here hoping this is a false prediction!

apple.news/AIY9nd6fESyi...

Preacher -> choir!

I’m still solidly in the camp of not even calling GG1 ‘cancer’ let alone treating it. But this is yet more support, imho, for early screening, _selective_ workup of ⬆️PSA, and tailored management of aggressive disease.

ICYMI: *30* year outcomes from SPCG-4
dx.doi.org/10.1056/NEJM...

RP vs. WW for clinically detected #prostatecancer reduces CSM 48% and *ACM* by 26%. NNT down to 6. Clear benefit to treatment of clinically detectable disease if (and only if) your pt has a very long life expectancy. #pcsm

Active surveillance for intermediate-risk prostate cancer rose from 5% in 2010 to 12.3% in 2020. Most common in GG1 cases (53.8% by 2020). PSA and GG remain key factors.
#ProstateCancer #ActiveSurveillance #Oncology #CancerResearch
@oncoalert.bsky.social

I have no clue what I’m looking at!
And it was shared 25k times??!
We all old. 👴