Jessica Alfoldi

A large crowd carrying signs and American flags gathered around an obelisk; a tall white steepled church stands in the background.

Greetings from this morning’s #NoKings rally on the Lexington MA Battle Green, which was packed with patriots once again to stand up against a corrupt and capricious would-be ruler. More photos… 🧵 @indivisible.org @universalhub.com

😍 Boston, you are beautiful. #NoKings

A poster about the No Kings Rally in Lexington, MA with featured speakers Bill McKibben and Massachusetts Poet Laureate Regie Gibson.

We are having a great No Kings! rally in Lexington with the tagline "It Started Here." Register and join us: www.mobilize.us/lexingtonala...

@lexingtonalarm.bsky.social
@swingbluealliance.org
@progressivemass.bsky.social
@mass50501.bsky.social

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Speculative Technologies Speculative Technologies is a nonprofit resarch organization unlocking new materials and manufacturing technologies

Applications for the 2026 cohort of the Brains Research Accelerator are now open!

If you have a deep technical background and an ambitious research idea that's beyond the scope of a startup or academic lab, you should apply!

spec.tech/brains

If you have questions, we have answers!

We are doing two Q+A sessions about AI Brains in the coming weeks:

1. June 3 at 8p ET: lu.ma/eli2c08p
2. June 9 at 1p ET: lu.ma/vxx85ug5

Applications are now open for a special cohort of the Brains Accelerator targeting ambitious AI research programs, with a special focus on security and governance capabilities!

spec.tech/ai-brains

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Hoppuðu upp í einkaþotu til að vera komnir til Íslands á undan mér „Þetta er ósköp einfalt, ég var boðaður á fund og sagt að ég væri rekinn,“ sagði Kári Stefánsson, sem staddur var í Kaliforníu þegar náðist í hann. „Síðan var ég skilinn eftir inni í herbergi, stjórne...

Kári Stefánsson, founder and CEO of deCODE Genetics, the Icelandic company wholly owned by Amgen but operated largely independently, has been fired.

www.mbl.is/frettir/innl...

Jobs — Imprint FRO Join our team—current openings at Imprint

Looking for a job in immunology or biotech research?
✨IMPRINT is #hiring! ✨

Join us to help revolutionize how we decode the body’s immune memory, uncover the causes of chronic diseases, and drive breakthroughs in autoimmunity and neuropsychiatric research.

#BiotechJobs #Immunology #sciencejobs

Spectech is hiring a program associate for the Brains Research Accelerator!

Are you/do you know someone relatively early in their career who has:
- Technical training
- Intense attention to detail
- An interest in ambitious research programs?

If so, please get in touch.

spec.tech/jobs

Ah yes, the morphological species concept, so snakes are lampreys are hagfish!

www.newscientist.com/article/2475...

My son Charlie — and the breakthrough that changed our lives James Coney and his wife, Sarah, struggled not knowing why their 12-year-old was born with a severe learning disability. In their darkest moments, they blamed themselves. Then, out of the blue, came a...

A few weeks ago, I had an incredibly emotional call with James Coney, a writer for the Sunday Times whose son Charlie was in the @genomicsengland.bsky.social 100k project and was recently diagnosed with ReNU syndrome. This beautiful article tells their story ❤️ www.thetimes.com/article/0bcc...

I wrote an extended essay attempting to:

- Synthesize the zeitgeist around universities, our research ecosystem, and technological stagnation

- Argue that part of the solution unbundling the roles the university has monopolized

- Suggest concrete actions to do that

unbundle-the-university.com

lord of the rings meme gimli i think idc: "never thought i'd die fighting side by side with an indirect cost rate" legolas but his face says 67.5%: "what about side by side with a friend?" same gimli: no dialogue

how it feels logging on today

Hey man sorry to hear about all your political turmoil. Would it help if I scrolled around on the computer all day and drove myself insane?

I was led to believe by R.E.M. that I would feel a lot better about this.

Meet the 2025 Brains Fellows We’re excited to introduce the 2025 class of Brains Fellows!

I'm excited to introduce the 2025 class of Brains Fellows!

We're working with these talented scientists and technologists to execute on ambitious ideas that are beyond the scope of individual academic labs, startups, or large companies.

Check out their ideas:
blog.spec.tech/p/meet-the-2...

Spectech Lessons and Updated Hypotheses from 2024 Things we got right, things we got wrong, and things we didn't know we didn't know

New post on the Speculative Technologies blog about lessons from 2024 and updated hypotheses going into 2025.

We got some things right, some things wrong, and uncovered some things we didn't know we didn't know.

blog.spec.tech/p/spectech-l...

🚀 Calling all visionary scientists and engineers! Announcing our call for Focused Research Organization proposals in the UK. 🔬Submit your concept paper by Feb 7 & full proposal by March 28. More here: www.convergentresearch.org/frost-uk ⤵️

It’s the 12th day of Christmas and there is so much shit I’ve got to return. So many birds.

Me agreeing to circle back in the new year: Haha fuck yeah!!! Yes!!

Me when they circle back in the new year: Well this fucking sucks. What the fuck.

I’ve gotten into Margins lately

He grinned a little as he thought it; for he had always liked that pause, that fearful pause, the moment before things changed.

Wood sculpture by Han Hsu Tung of a hand in mid-pixelation

Wood sculpture by Han Hsu Tung of a terracotta soldier in mid-pixelation

The work of Taiwanese sculptor Hsu Tung Han 韓旭東 - of wood sculptures carved as if pixelated and uploading

[Via his Flickr www.flickr.com/photos/hsutu...

FutureHouse is launching an independent postdoctoral fellowship program for exceptional researchers who want to apply our automated science tools to specific problems in biology and biochemistry, in collaboration with world-leading academic labs. 1/

🏆 A Biologist’s Guide to Mars Dirt Just add water

Check out 🏆A Biologist’s Guide to Mars Dirt, where we present a receipt for soluble Mars Regolith Media (sMRM) that best simulates what you’d get if you added water to Mars dirt.

Will anything grow in this media? Stay tuned!

💧+ 🪨 → 🌱 ?

open.substack.com/pub/pioneerl...

the thing about using ChatGPT as a search engine is that we literally solved the problem of reliable search engines a decade ago, proceeded to destroy that in search of ad revenue, then reinvented it again, but somehow weirdly reliant on reddit shitposts

Giving Tuesday An excuse to support new institutions and an amazing future.

It's giving Tuesday!

Why, of the 1.97 million nonprofits in the United States, should you support Speculative Technologies?

- We're fast, lean, and relentless
- We’re in a class of one
- It’s a vote for an amazing future
- Social Proof!

I unpack those reasons here:
substack.com/home/post/p-...

🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.

Read more: e11.bio/news/roadmap

The Great Pokémon Go Spy Panic How a global hit sparked digital paranoia inside U.S. intelligence.

gift link for the non-subscribers - foreignpolicy.com/2024/11/29/p...