Jenn Kim

FIRST post here on Bluesky - we’re excited to share that our large spatial transcriptomics study of the human dlPFC in schizophrenia is now available on bioRxiv📄: www.biorxiv.org/content/10.6... (1/9)

#patchcult 😎

Bad Bunny sends a message at the Super Bowl:

"God Bless America"

"The only thing more powerful than hate is love"

Keri Martinowich, Ph.D., Chief Scientific Officer | The Lieber Institute for Brain Development | Research & Discovery Lieber Institute for Brain Development Appoints Keri Martinowich, Ph.D., as Chief Scientific Officer Baltimore, MD (January 6, 2025) — The Lieber Institute for Brain Development (LIBD) announced the a...

Honored to be appointed Chief Scientific Officer @lieberinstitute.bsky.social. LIBD is a uniquely collaborative place with extraordinary biological resources and a commitment to translation 🧠🔬🧪. Grateful to my colleagues and excited to help guide our next chapter!
www.libd.org/keri-martino...

Ollie (left, black and white dog) and Bella (right, brown and white dog) cuddling nose to nose

Happy new year from Ollie & Bella 🐾 May your 2026 be as cozy and warm as these two ❤️

How basic neuroscience has paved the path to new drugs A growing list of medications—such as zuranolone for postpartum depression, suzetrigine for pain, and the gepants class of migraine medicines—exist because of insights from basic research.

“Basic neuroscience hasn’t produced new drugs.” 💊

Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab.

I wrote a Perspective on why this matters. @thetransmitter.bsky.social

www.thetransmitter.org/drug-develop...

Top-down control of sustained attention by the medial prefrontal cortex (mPFC)- locus coeruleus (LC) circuit during the rodent continuous performance task (rCPT) The medial prefrontal cortex (mPFC) plays a pivotal role in attention by exerting top-down control to allocate cognitive resources toward behaviorally relevant stimuli based on learned context and exp...

Finally on Bluesky and I’m really excited to share this latest preprint with @jorge-miranda.bsky.social in which we functionally examined the role of a medial prefrontal cortex (mPFC)- Locus Coeruleus (LC) circuit in regulating sustained attention.

1/7

www.biorxiv.org/content/10.6...

Experimental design for LIBD LFF Spatial ERC project

Excited to share our latest preprint from @lieberinstitute.bsky.social spatial + single-cell RNA-seq map the ERC & explore how AD risk shapes gene expression doi.org/10.1101/2025...
Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”

Excited to share new preprint led by Sergio Salas on “unassigned RNAs” in imaging-based spatial transcriptomics. Across technologies, 30-40% of transcripts fall outside segmentation, & many show structured, biologically meaningful extrasomatic patterns.
📄 www.biorxiv.org/content/10.6...

Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online

www.nature.com/articles/s41...

7 basic science discoveries that changed the world Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.

Scientists point to a long list of findings that emerged out of fundamental research, the type of studies the US government is cutting, and went on to change the world. Nature lists a few of their examples. 🧪

And ofc, an unforgettable time with the best class 😎 huge thank you to all the course leaders and lecturers for the fun and incredible learning experience! 3/

Also had the opportunity to generate/analyze our own data, which was really useful to solidify all the new concepts we learned about. Some fun lab pics fr/ preparing virus, dissecting brain regions for MAPseq, brain tissue clearing, and in situ sequencing our BARseq-prepped tissue on the scope 🤩 2/

Had the most rewarding time at the HTNA #cshlcourses It was fun science-ing all day/night for 2wks to learn modern viral, whole 🧠 imaging & barcode-based seq approaches to understand neuroanatomy/function. Inspired & energized as I think of all the ways these tools can be applied in my own work!🧪 1/

Circuit-specific gene editing for precision modulation of neuronal activity with CRISPR-rabies virus https://www.biorxiv.org/content/10.1101/2025.11.03.686433v1

Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...

Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...

My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...

YouTube video by Leonardo Collado Torres [2025-10-16] What Makes a Good Data Visualization?

"What Makes a Good Data Visualization?" 🤔

Check @christinezhang.bsky.social's 🤩 excellent 💯 guest lecture for 140.776 Statistical Computing at @johnshopkinssph.bsky.social

📽️: youtu.be/SeLucCb05Dk

Slides: speakerdeck.com/lcolladotor/...

#RStats @jhubiostat.bsky.social @lieberinstitute.bsky.social

Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue…

Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke.
www.sciencedirect.com/science/arti...

Effective and empathetic scientific communication is so critical right now. We had an interactive workshop at the #2025ICDB led by @rebeccacalisi.bsky.social and Dr. Kevin Alicea-Torres and facilitated by @spiraldoc.bsky.social and myself- and we practiced this. Please check out our perspective!

All scientists can easily respond to this and you can choose to stay anonymous. I modified my comment from the FASEB response. We all know that international scientists are essential to US science and that these proposed rules are cruel to our colleagues. www.regulations.gov/comment/ICEB...

Careers at LIBD | Medical Research Jobs | Lieber Institute View our career opportunities with Lieber Institute for Brain Development including investigators, medical research jobs, scientists, & lab techs

We have several positions open at various levels (Research Assistant, Research Associate, Postdoctoral Fellow) across our highly interactive teams in the Division of Translational Neuroscience 🧠🔬🧪 @lieberinstitute.bsky.social

www.libd.org/careers/

Links to individual positions in the thread below.

YouTube video by Jimmy Kimmel Live Jimmy Kimmel is Back!

As I was saying…

🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

Look at academia giving me a little hope

AILA: Trump Administration H-1B Crackdown and “Gold Card” Visa Imperil Jobs, Innovation, and Rural Healthcare AILA President Jeff Joseph and ED Ben Johnson responded to the Trump Administration attempting to apply a new $100,000 fee to H-1Bs and supplant existing visa programs with a “Gold Card” visa, noting ...

The Trump Administration has announced measures to gut longstanding pathways based on exceptional ability, national interest, & merit in favor of pay-to-play immigration. @urbanviewradio.bsky.social

This sends a signal to the world’s top talent that the U.S. is closing its doors. bit.ly/4nz1XBE

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Yes, I am on the academic job market looking to start my own lab at the intersection of molecular, computational, and systems neuroscience! If you think my work may be interest to your department, please don't hesitate to reach out.

Thank you, Keri!

See How Alzheimer's Disease Works—And How the Newest Treatments Fight It While our understanding of Alzheimer’s disease is far from complete, the latest therapies, and others in more than 100 clinical trials, offer new hope

I love how this feature uses graphics to explain the latest thinking on possible Alzheimer's causes and the many treatment targets. @sciam.bsky.social @jenchristiansen.com @estherlandau.bsky.social

Congratulations to @mictott.bsky.social, Rita Cervera Juanes and @svitlanabach.bsky.social and all co-authors! Really fun collaboration w/labs of @vincentcostaphd.bsky.social and @stephaniehicks.bsky.social to better understand cell type and spatial heterogeneity across amygdala in primate 🧠!