Leah Rosin's Avatar

Leah Rosin

@scienceleah.bsky.social

Scientist. Mom. Meiosis, mitosis, and gene regulation. Moth and fly model systems πŸ¦‹πŸͺ° Microscopy and genomics πŸ”¬πŸ§¬ Views are my own.

699 Followers  |  433 Following  |  13 Posts  |  Joined: 04.09.2023
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Posts by Leah Rosin (@scienceleah.bsky.social)

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

New paper from the Rosin lab in collaboration with the Hawley lab πŸŽ‰ Spearheaded by postdoc Leif Benner. We use imaging and RNA-seq to better understand apyrene meiosis.

Programmed meiotic errors facilitate dichotomous sperm production in the silkworm, Bombyx mori.

www.pnas.org/doi/10.1073/...

25.02.2026 17:56 β€” πŸ‘ 11    πŸ” 3    πŸ’¬ 3    πŸ“Œ 1

I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.

Descriptions and links in the following two posts.

28.08.2025 20:47 β€” πŸ‘ 158    πŸ” 123    πŸ’¬ 2    πŸ“Œ 5
Preview
Programmed meiotic errors facilitate dichotomous sperm production in the silkworm, Bombyx mori The goal of meiosis is typically to produce haploid gametes (eggs or sperm). Failure to do so is catastrophic for fertility and offspring health. However, Lepidopteran (moths and butterflies) males pr...

So excited to share this preprint from the Rosin lab in collaboration with the Hawley lab and @eelcotromer.bsky.social on moth spermatogenesis! We investigate the meiotic errors that occur during the formation of apyrene sperm (that have no DNA) in silkworms!

www.biorxiv.org/content/10.1...

04.08.2025 10:38 β€” πŸ‘ 27    πŸ” 12    πŸ’¬ 1    πŸ“Œ 0

So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). πŸ™ amplify!

25.06.2025 01:01 β€” πŸ‘ 98    πŸ” 72    πŸ’¬ 3    πŸ“Œ 2
The aim of this proposal is to place population genomic insights into a comparative framework to gain fundamental insights into the determinants of evolutionary outcomes. The project will work within LepEU, the European Lepidopteran Population Genomics Consortium (https://lepeu.github.io/). LepEU provides access to field samples from European populations of diverse species. Chromosome-scale reference genomes are provided by Project Psyche (https://www.projectpsyche.org/). Networking during the postdoc will be facilitated by participation in the 10kLepGenomes COST Action (https://10klepgenomes.eu/). Existing datasets await analysis, while additional samples need DNA extraction and submission for sequencing. Functional validation capability (CRISPR/Cas9 gene manipulations) is also available to test emergent hypotheses of allele-to-phenotype impacts. Personal research interests of the postdoc will be important to determine the exact project, as the project has a generous sequencing budget.

The aim of this proposal is to place population genomic insights into a comparative framework to gain fundamental insights into the determinants of evolutionary outcomes. The project will work within LepEU, the European Lepidopteran Population Genomics Consortium (https://lepeu.github.io/). LepEU provides access to field samples from European populations of diverse species. Chromosome-scale reference genomes are provided by Project Psyche (https://www.projectpsyche.org/). Networking during the postdoc will be facilitated by participation in the 10kLepGenomes COST Action (https://10klepgenomes.eu/). Existing datasets await analysis, while additional samples need DNA extraction and submission for sequencing. Functional validation capability (CRISPR/Cas9 gene manipulations) is also available to test emergent hypotheses of allele-to-phenotype impacts. Personal research interests of the postdoc will be important to determine the exact project, as the project has a generous sequencing budget.

The successful applicant should have a PhD (obtained within 6 years of the application deadline) in a suitable subject area, such as evolutionary biology or population genomics. A strong interest in population genomics, local adaptation, comparative analyses, and experience working with genomic-scale data is essential. The candidate must have a documented publication record demonstrating relevant skills. Experience working with bioinformatic pipelines (e.g., Snakemake), or working with butterflies is welcome but not essential. The net salary is 28,000 SEK/month (~2,430 Euro, not subject to Swedish income tax) and comes directly from the Carl-Trygger Foundation stipend, which is paid out directly to the postdoc. Only PhD candidates acquired outside of the host department can apply. Currently, the lab of Prof. Wheat consists of 3 postdoctoral researchers, while the Dept. of Zoology provides a vibrant and excellent research environment of active, dynamic researchers. 

Applications should include: i) a succinct description of research interests and experience, detailing your contribution to any relevant publications (max 1 page), ii) why you are the ideal candidate for this position in the lab (max 1 page); iii) a CV including a list of publications, and iv) the name and contact information of two personal references. 

Applications will be reviewed on a rolling basis with a deadline of 23 August 2025. The project is planned to start on 1 October, but flexibility in the starting date can be provided for a suitable candidate. Please contact Prof. Wheat for additional information.

The successful applicant should have a PhD (obtained within 6 years of the application deadline) in a suitable subject area, such as evolutionary biology or population genomics. A strong interest in population genomics, local adaptation, comparative analyses, and experience working with genomic-scale data is essential. The candidate must have a documented publication record demonstrating relevant skills. Experience working with bioinformatic pipelines (e.g., Snakemake), or working with butterflies is welcome but not essential. The net salary is 28,000 SEK/month (~2,430 Euro, not subject to Swedish income tax) and comes directly from the Carl-Trygger Foundation stipend, which is paid out directly to the postdoc. Only PhD candidates acquired outside of the host department can apply. Currently, the lab of Prof. Wheat consists of 3 postdoctoral researchers, while the Dept. of Zoology provides a vibrant and excellent research environment of active, dynamic researchers. Applications should include: i) a succinct description of research interests and experience, detailing your contribution to any relevant publications (max 1 page), ii) why you are the ideal candidate for this position in the lab (max 1 page); iii) a CV including a list of publications, and iv) the name and contact information of two personal references. Applications will be reviewed on a rolling basis with a deadline of 23 August 2025. The project is planned to start on 1 October, but flexibility in the starting date can be provided for a suitable candidate. Please contact Prof. Wheat for additional information.

🚨Postdoc opportunity🚨: LepEU postdoc: comparative population genomics of European scale adaptation in butterflies

2 year, full-time PD in my group, Stockholm Univ.

Applications assed on rolling basis, deadline: 23 August 2025. Planned start 1 Oct.

Details:
christopherwheatlab.wordpress.com

22.06.2025 18:20 β€” πŸ‘ 64    πŸ” 71    πŸ’¬ 0    πŸ“Œ 0

🚨 A new rule would let career scientists like NSF/NIH program officers be replaced by political appointees

Already 14,000+ public comments, deadline is Friday

πŸ“£ Comments can be short. Courts consider themβ€”and scientists with NSF/NIH experience are especially impactful

Speak up! shorturl.at/WKuBj

21.05.2025 17:39 β€” πŸ‘ 538    πŸ” 510    πŸ’¬ 25    πŸ“Œ 51
Recruitment

We're hiring an entomology collections manager @nhm.org ! I have nothing to do with the search, but happy to answer questions about the museum & LA!
πŸ§ͺπŸ¦‹πŸπŸžπŸœπŸ¦—πŸͺ°πŸͺ²πŸͺ³πŸ•·οΈ
workforcenow.adp.com/mascsr/defau...

23.05.2025 01:17 β€” πŸ‘ 39    πŸ” 30    πŸ’¬ 0    πŸ“Œ 0
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@jeffsekelsky.bsky.social Corbin Jones, & I give huge thanks to Frank McNally, Christoph Haag, Andy Kern, Bengt Hansson, @takashiakeralab.bsky.social & @scienceleah.bsky.social for being guests in our #Meiosis, Recombination, & Evolution of Sex class at UNC. A pic from our final session w/ students

25.04.2025 19:45 β€” πŸ‘ 9    πŸ” 5    πŸ’¬ 0    πŸ“Œ 2
Preview
An optogenetic toolkit for robust activation of FGF, BMP, and Nodal signaling in zebrafish Cell signaling regulates a wide range of biological processes including development, homeostasis, and disease. Accessible technologies to precisely manipulate signaling have important applications in ...

Happy to share a new preprint from my lab! We characterize the on/off kinetics, light dosage-dependence, and more for a suite of optogenetic signaling activators in zebrafish embryos πŸ’‘ www.biorxiv.org/content/10.1...

21.04.2025 13:47 β€” πŸ‘ 105    πŸ” 36    πŸ’¬ 9    πŸ“Œ 4

I’m excited to share a new preprint from some of my work in the lab of @toddmacfarlan.bsky.social ! πŸ˜„

We dived into young KZFP gene clusters in different mouse strains and species to uncover mechanisms that facilitated their evolution and diversification in mice

03.03.2025 18:41 β€” πŸ‘ 30    πŸ” 12    πŸ’¬ 3    πŸ“Œ 3
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Our (@jeffsekelsky.bsky.social Corbin Jones, & me) #Meiosis, Recombination & Evolution of Sex class @uncchapelhill.bsky.social loved talking w/ @scienceleah.bsky.social about her lab's @plos.org Genetics paper on a unique chromosome segregation mechanism in holocentric moths. doi.org/10.1371/jour...

11.04.2025 19:31 β€” πŸ‘ 12    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
Image of three covers of Journal of Cell Science

Image of three covers of Journal of Cell Science

Did you know…
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...

09.04.2025 14:32 β€” πŸ‘ 98    πŸ” 48    πŸ’¬ 1    πŸ“Œ 1

New preprint drop! Check out work from @jimmy-ly.bsky.social et al for how protein isoforms generated by alternate translation initiation create dual localization, contribute to mitochondrial function, and are mutated in disease. "Blue-tutorial" thread below.

www.biorxiv.org/content/10.1...

28.03.2025 10:41 β€” πŸ‘ 61    πŸ” 22    πŸ’¬ 1    πŸ“Œ 1

We are all so upset about this, Needhi. πŸ˜“

26.03.2025 02:02 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Postbac Program

She should apply to the NIH postbac program! We can’t bring new trainees in at the moment but I’m hoping that changes by the summer 🀞

www.training.nih.gov/research-tra...

15.03.2025 15:45 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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🚨 New Paper Alert! 🚨

🐜 How did ants evolve their highly specialized queens and workers?

With @adriatica.bsky.social, we reveal a key evolutionary innovation: adult control over larval feeding unlocked extreme caste dimorphism and complex societies. πŸ§΅πŸ‘‡

πŸ”— Read in @pnas.org: doi.org/10.1073/pnas...

26.02.2025 12:37 β€” πŸ‘ 73    πŸ” 37    πŸ’¬ 2    πŸ“Œ 3

First mouse paper out from Elissa Lei’s lab! Congrats Dahong and all authors πŸ­πŸπŸ§¬πŸ‘€

β€œCTCF regulates global chromatin accessibility and transcription during rod photoreceptor development”

www.pnas.org/doi/10.1073/...

24.02.2025 22:50 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Aneuploidy of specific chromosomes is beneficial to cells lacking spindle checkpoint protein Bub3 Author summary Accurate chromosome segregation is crucial for the proper development of all living organisms. Errors in chromosome segregation can lead to aneuploidy, characterized by an abnormal numb...

Check out our super cool paper on aneuploidy in cells lacking Bub3. Congratulations to fantastic student Pallavi Gadgil and alum Olivia Ballew. journals.plos.org/plosgenetics...

21.02.2025 18:41 β€” πŸ‘ 39    πŸ” 10    πŸ’¬ 3    πŸ“Œ 4
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I am thrilled to share our new review on holocentric chromosomes. It was a lot of fun to write it together with Ines Drinnenberg!
Same but different: Centromere regulations in holocentric insects and plants doi.org/10.1016/j.ce...

21.02.2025 09:17 β€” πŸ‘ 83    πŸ” 44    πŸ’¬ 3    πŸ“Œ 1
Preview
Genome Assembly of a Living Fossil, the Atlantic Horseshoe Crab Limulus polyphemus, Reveals Lineage-Specific Whole-Genome Duplications, Transposable Element-Based Centromeres, and a ZW Sex Chromosome ... Abstract. Horseshoe crabs, considered living fossils with a stable morphotype spanning ∼445 million years, are evolutionarily, ecologically, and biomedical

This is so cool!!
Congrats @roneilllab.bsky.social and team! πŸ¦€πŸ§¬

academic.oup.com/mbe/article/...

21.02.2025 00:39 β€” πŸ‘ 7    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Do you love meiosis? Have a cool story to share? Join us for the XVth British Meiosis Meeting 26-27 of March in Liverpool! docs.google.com/forms/d/e/1F... You only have till Sunday to submit an abstract for a talk! ECRs are prioritised for speaking slots so the odds are in your favour 😁 #meiosis4eva

19.02.2025 11:30 β€” πŸ‘ 13    πŸ” 9    πŸ’¬ 1    πŸ“Œ 0

Almost 200 people signed up already - add your name soon before we have to stop registration for this once in a life time conference! docs.google.com/forms/d/1dm8...

09.02.2025 15:40 β€” πŸ‘ 29    πŸ” 15    πŸ’¬ 1    πŸ“Œ 1

I just heard the news that R Scott Hawley, meiosis enthusiast and founding Dean of the Grad School of the Stowers Institute for Medical Research, passed away today. Such a loss for the science and education community. I will miss our zooms and his deep, deep wisdom

31.01.2025 18:50 β€” πŸ‘ 103    πŸ” 14    πŸ’¬ 10    πŸ“Œ 4
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Feeling very lost today with the news of the passing of my undergrad advisor Scott Hawley. He had a huge impact on the field and on me personally. He was the first person to see me as a scientist and gave me the confidence to apply to grad school. I am so grateful to be a part of his legacy.

31.01.2025 16:36 β€” πŸ‘ 153    πŸ” 14    πŸ’¬ 17    πŸ“Œ 3
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Sadly, our colleague and friend Scott Hawley passed away this morning. He was an irreplaceable presence and force for good in the meiosis an Drosophila communities and will be sorely missed.

31.01.2025 15:45 β€” πŸ‘ 125    πŸ” 44    πŸ’¬ 27    πŸ“Œ 13

Scientists of Bluesky - qPCR machine recs?

14.12.2024 21:23 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
A collage of book covers of new nature & science books. Featured here are Atlas Obscura Wild Life, Dinosaurs at the Dinner Party, Every Living Thing, Alien Earths, Becoming Earth, and Deep Water

A collage of book covers of new nature & science books. Featured here are Atlas Obscura Wild Life, Dinosaurs at the Dinner Party, Every Living Thing, Alien Earths, Becoming Earth, and Deep Water

A collage of book covers of new nature & science books. Featured here are Frostbite, The Inner Clock, How to Kill an Asteroid, The Great River, The Last Fire Season, and Hoof Beats

A collage of book covers of new nature & science books. Featured here are Frostbite, The Inner Clock, How to Kill an Asteroid, The Great River, The Last Fire Season, and Hoof Beats

A collage of book covers of new nature & science books. Featured here are The Serviceberry, Not the End of the World, Nature's Ghosts, Meet the Neighbors, The Light Eaters, and Our Moon

A collage of book covers of new nature & science books. Featured here are The Serviceberry, Not the End of the World, Nature's Ghosts, Meet the Neighbors, The Light Eaters, and Our Moon

A collage of book covers of new nature & science books. Featured here are Turning to Stone, The Weight of Nature, What If We Get It Right?, Waves in An Impossible Sea, The Tree Collectors, and Why We Remember

A collage of book covers of new nature & science books. Featured here are Turning to Stone, The Weight of Nature, What If We Get It Right?, Waves in An Impossible Sea, The Tree Collectors, and Why We Remember

I was deeply disappointed by the lack of nature/science/climate/enviro on many major end-of-year book listsβ€”so I decided to make my own!

Introducing: βœ¨πŸŽπŸ“š The 2024 Holiday Gift Guide to Nature & Science Books βœ¨πŸŽπŸ“š

Please share: Let's make this go viral in time for Black Friday / holiday shopping!

27.11.2024 19:08 β€” πŸ‘ 9462    πŸ” 2649    πŸ’¬ 357    πŸ“Œ 214
Post image A multi-colored UMAP projection on a white background of single-cell transcriptomes, colored by major tissues.

A multi-colored UMAP projection on a white background of single-cell transcriptomes, colored by major tissues.

Our #SpotlightZebrafish this week is on Dr. Abhinav Sur, a #postdoc w/ Dr. Jeff Farrell @ NICHD. His research uses single-cell transcriptomes to identify & map distinct populations across 62 stages of zebrafish embryogenesis & early larval development. (1/3)

25.09.2023 15:05 β€” πŸ‘ 15    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0
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Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape - Genome Biology Background Centromeres depend on chromatin containing the conserved histone H3 variant CENP-A for function and inheritance, while the role of centromeric DNA repeats remains unclear. Retroelements are...

Our paper on a centromere-enriched retroelement is out! link.springer.com/article/10.1... Congratulations to all the authors! Comments and reposts welcome and appreciated πŸ§¬πŸ”¬

18.11.2024 17:50 β€” πŸ‘ 80    πŸ” 45    πŸ’¬ 4    πŸ“Œ 1
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2024 Mid-Atlantic Meiosis Mini-Symposium!! 🐭πŸͺ±πŸͺ°πŸ§¬πŸ¦ Co-organized with @scienceleah.bsky.social and @florpratto.bsky.social at NIH. Amazing talks from trainees and new PIsπŸŽ‰ #meiosis4eva

16.11.2024 16:16 β€” πŸ‘ 22    πŸ” 8    πŸ’¬ 1    πŸ“Œ 1