Vincent Pasque

Exciting Research Professorship Position in Stem Cell and Developmental Biology at the University of Leuven. Amazing research ecosystem, great colleagues, high quality of life, tenure track. For those interested in joining us, please see below:
www.kuleuven.be/personeel/jo...

It was fun reflecting on how my career path took me from a focus on cancer research to developmental biology, the urge to understand how development and tissue homeostasis work and how my time at the @biozentrum.unibas.ch contributed to this. Thank you, Katrin Bühler-Popowski, for the interview!

Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...

1/10🧵 New preprint! 🚀
We built a resource of 20 clonal human naïve pluripotent stem cell lines from 10 blastocysts. Explore embryo-to-embryo and clone-to-clone variation in one place.
👉doi.org/10.1101/2025.06.02.657331

We are delighted to share our new preprint “X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels”.
biorxiv.org/content/earl...

⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.

Join us in the #institutcurie exceptional environment to explore the mysteries of X chromosome regulation in early human development

Evaluating totipotency using criteria of increasing stringency - Nature Cell Biology Posfai, Schell, Janiszewski et al. assess candidate totipotent stem cells with in vitro and in vivo assays of increasing stringency to evaluate their developmental potential and lineage contributions.

On a personal note, I feel privileged to have collaborated with her. Her passion and insight continue to motivate us.

Here’s a paper we worked on together - a small part of her big impact: www.nature.com/articles/s41...

Janet, this award is well deserved. Congratulations!

I am delighted to congratulate Janet Rossant on receiving the LSO Lifetime Achievement Award! Janet’s work on early embryos has shaped the field and inspired so many of us.

Here is a wonderful video about Janet and her recent award: www.youtube.com/watch?v=ZZa7...

You can follow our team on our new webpage: institut-curie.org/team/rougeulle

I’m incredibly proud to share the results of our lab’s first project, leading to the exciting discovery – Aging promotes reactivation of the Barr body at distal chromosome regions – now published in @nataging.nature.com!
🔗 tinyurl.com/3jkzzy7d

And thank you also to our sponsors, Hologic Diagenode, Active Motif and Bioké.

Many thanks to the Leuven Cancer Institute and the KU Leuven Institute for Single Cell Omics for supporting the initiative. lisco.kuleuven.be/leuven-epige...

We are excited to host Dr. Maxim Greenberg and Dr. Courtney Hanna this week to kickoff the Leuven Epigenetics Club!

Ebrahimkhani LAB Ebrahimkhani lab studies tissue morphogenesis using systems and synthetic biology. Our approach integrates synthetic biology with stem cells and regenerative medicine to discover new therapies and und...

Contact Mo Ebrahimkhani. www.ebrahimkhanilab.bio

Excited to share that I have been recognized as a 2025 ISSCR Public Service Award Honoree! Read more about the award and my fellow honorees.
www.isscr.org/isscr-news/i...

A transcriptional clock of the human pluripotency transition Developmental timing differs strikingly between mammals. All embryonic and some placental lineages emerge from the pluripotent epiblast in a temporally defined sequence, lasting about two weeks in the...

A transcriptional clock of the human pluripotency transition. www.biorxiv.org/content/10.1...

Figure 1 Schematics of extra-embryonic mesoderm development across species. (A) An intermediate stage of reptilian development displaying the vascularized trilaminar omphalopleure, also known as choriovitelline membrane, and the bilaminar omphalopleure. (B) A later developmental stage in squamates, showing a feature unique to squamates: the yolk cleft. The composition of the amnion, allantois and chorion is similar in all reptiles. (C) E1 (24 h) chick embryo showing the primitive streak, area vitellina and vasculosa. (D) E10 chick embryo displaying the localization of vascularized and non-vascularized extra-embryonic mesoderm (EXM) cells.

In this Review, @eliananehme.bsky.social, @amiteshp.bsky.social, Isabelle Migeotte and @pasquelab.bsky.social give an overview of the embryonic origin and function of extra-embryonic mesoderm in vertebrates from in vivo studies.
journals.biologists.com/dev/article/...

Symposium on ‘Enhancer Sequences’ at beautiful @collegedefrance.bsky.social in Paris, by April 11th. Open and free, no registration. Come to relax listening to facts #TherapeuticEffects #VillageGauloix Final programme below. Tell your friends! 🙏🤘

In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.

Vinod's team's work could have saved my wife's life, and I hope this and others like it will make a huge difference with patients with seemingly untreatable deadly diseases. This needs to be able to continue. www.mskcc.org/news/can-mrn...

Fantastic study and collaboration led by stellar postdoc @ioansarr.bsky.social, it was a pleasure to host you in the lab (& thanks to @embo.org for the visiting fellowship)

I really encourage this great initiative & hope to visit the Young People's Forest in Mead someday!

#EarlyHumanDevelopment #StemCellEmbryoModels #ExtraEmbryonicMesoderm #ForestOfBiologists #SustainableScience @dev-journal.bsky.social @eliananehme.bsky.social @amiteshp.bsky.social

Landscape - The Forest of Biologists

It was super fun to write this article together with Eliana Nehme, Amitesh Panda and Isabelle Migeotte.

I am also pleased that a tree was planted in the Forest of Biologists on behalf of our paper! 🌱🌳
forest.biologists.com/landscape/?i...

Extraembryonic mesoderm cells are crucial for early embryonic development, but often overlooked. In our review, we explore their origins, key regulators, and role in various newly developed stem cell-based embryo models, shedding light on this essential cell lineage.

Excited to share our recent review on extraembryonic mesoderm development, just published in Development!

"Extra embryonic mesoderm during development and in in vitro models."

journals.biologists.com/dev/article/...

Europe could be a ‘haven’ for US researchers, says ERC president The EU’s research funding bodies are thinking of ways to welcome US scientists and European ex-patriots who might be looking for a more sympathetic place to work now that Donald Trump is in the White ...

Europe as “a haven” for US researcher - The EU’s research funding bodies are thinking of ways to welcome US scientists and European ex-patriots who might be looking for a more sympathetic place to work now that Donald Trump is in the White House
#AcademicSky 🧪

sciencebusiness.net/internationa...

Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee Naive pluripotent stem cells (PSCs) are counterparts of early epiblast in the mammalian embryo. Mouse and human naive PSCs differ in self-renewal requ…

Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee. www.sciencedirect.com/science/arti...

Genome-coverage single-cell histone modifications for embryo lineage tracing - Nature Two new methods, target chromatin indexing and tagmentation (TACIT) and combined TACIT (CoTACIT), enabled single-cell profiling of the epigenome and lineage tracing from mouse zygotes to blastocy...

Genome-coverage single-cell histone modifications for embryo lineage tracing.
www.nature.com/articles/s41...

We keep searching, because knowledge has no end.

Science is everywhere.

Happy 600th birthday to the University of Leuven!

Exciting work from our neighbors. Congrats to all involved.