Sahana Holla

Stress makes memories...epigenetically speaking!!
A histone ubiquitylation “stress switch” lets environmental signals lock into heterochromatin, passing on epigenetic memories long after the stress is gone. Fantastic story! Congrats @grewalsh.bsky.social‬ @bharat-bhatt.bsky.social and team! 👏👏

Read in Nature: nature.com/articles/s41586-025-09899-8

Stress controls epigenetic inheritance!

A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer
👉 nature.com/articles/s41586-025-09899-8

Grateful for the warm welcome @tifrhyderabad.bsky.social :) Thrilled to be part of this vibrant scientific community and eager to build an exciting research program!

Thank you, Yamuna! :)

Thank you, Shiv! Means a lot coming from you!

So proud of you, @sahanaholla! Watching your journey has been such a joy. Wishing you all the best as you begin this exciting new chapter at TIFRH. They’re lucky to have you!

The Holla Lab is hiring at all levels!!! If you're interested, reach out at sholla@tifrh.res.in with your CV and a brief description of your research. Feel free to share with others who might be keen. Recruitment ads coming soon! 📢

Thrilled to share that I’ve joined @tifrhyderabad.bsky.social as an Assistant Professor! Grateful to my mentors (esp @grewalsh.bsky.social and KN Balaji), colleagues, friends, family & EVERYONE who made this possible. Excited to explore Epigenetics & the 3D Genome with the brilliant minds in India!

AGO2 slicing of a domesticated retrotransposon is necessary for normal vasculature development Argonaute (AGO) mediated slicing of RNA, also known as RNAi, is a highly conserved phenomenon that is evolutionarily linked to the repression of transposons and other repeats. Although RNAi is no long...

What was that you said? You are looking for new #RNA research to read in the weekend?

You are in luck!

📣 📣 Check out the new preprint from our lab!!!! 📣 📣

www.biorxiv.org/content/10.1...

Beautiful work!! Congratulations to @grewalsh.bsky.social, Manjit and team!! 👏🏻👏🏻

🎉 CONGRATULATIONS to Manjit Srivastav, Diego Folco, Patroula Nathanailidou, Anupa Anil, Drisya Vijaykumari, Shweta Jain, Jothy Dhakshnamoorthy, David Wheeler, and our amazing collaborators Maura O’Neill and Thorkell Andresson! Your unwavering dedication, hard work, and passion are truly inspiring 🙌✨

🔬Decoding Silencing: How Heterochromatin Transcribes to Silence Itself!
🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...

Evolution and function of chromatin domains across the tree of life - Nature Structural & Molecular Biology Szalay et al. discuss cross-kingdom similarities and differences in 3D chromatin folding in relation to gene regulation, including in bacteria, archaea, mammals and plants. This comparison reveals cer...

🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!

Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!

SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...

Very happy to see @grothlab.bsky.social , @helink.bsky.social and @grewalsh.bsky.social all migrating over here! All pillars of the the #epigenetics and chromatin community.