Reproductive BioMedicine Online

Issue 39 of RBMO Insights is out today!

This month we talk lab witnessing, ovarian reserve, congenital anomalies in ART, preview our 'submission masterclass' RBMO Live webinar in September, spotlight our Reproductive Endocrinology and Health section, and more!

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This study has implications for PTX-treated cancer survivors; revealing details about the timing of conception and offspring safety after chemotherapy, offering a basis for for patients treated with PTX therapy.

available now as a pre-proof from our in-press articles

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This study is the first to show that hormonal replacement therapy may lead to a significant increase in serum TSH levels in women undergoing HRT for endometrial preparation before embryo transfer.

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This new study from The Rotterdam Periconception Cohort project team at Erasmus MC, University Medical Center, demonstrates that a higher degree of periconceptional vulnerability, as quantified by the PVRS is inversely associated with embryonic growth parameters.

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This work reflects real clinical practice, and provides a proof of concept methodology that IVF centres may employ to establish their own thresholds which after validation, can be used for patient counseling and to facilitate the workload of the IVF laboratory.

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This study demonstrates that objectively trained AI tools such as EMBRYOLY can support embryologists in difficult scenarios, especially in cases where they might be discouraged from transferring any embryo even though these stand a chance to lead to a pregnancy.

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In the pathogenesis of endometriosis, LINC01638 may act as a chromatin remodeller by modulating the levels of expression of HDAC1 to induce partial EMT in endometriotic lesions.

RBMO subscribers can read the full paper from issue, 51.3, now:

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Comparing euploidy rates between blastocysts derived from poor- and good-quality day 3 embryos, this study demonstrates that the morphology of day 3 embryos does not influence the quality of the transferrable blastocysts they develop into.

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Our August issue, 51.2 is published in full on our website now, featuring 24 original research and review articles, viewpoints and commentaries from our eight specialist subject sections - including 10 open access and free articles

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The positive effects of HNG shown in this study may ameliorate the ovarian damage induced by CTX chemotherapy, which suggests the need for further investigation of HNG as a protective agent of the ovary.

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This review from Pierpaolo Nicolì, and team summarizes available data on the outcomes of oocyte cryopreservation and subsequent IVF, while taking into account patients’ characteristics.

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A paper demonstrating that critical thinking and open debate are essential not only to science but also to improving the care we provide our patients.

Read the Commentary for free from issue 51.2

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#RBMOcommentary #ClinicalAssistedReproductiveTechnology #PeerReview

This Commentary discusses the importance of mindful reading of research, looking for the nuances in interpretation of RCT findings, problems of generalizing studies, shortcomings in peer review processes, and other factors influencing the practical values of papers from prestigious publications

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Using a recent Lancet-published article as an example, this Commentary highlights how critical manuscript reading remains essential even when an article is of otherwise high quality and published in a high-impact journal.

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Although ethanol sclerotherapy has been used since the 1980s, its clinical application in the context of fertility preservation has been largely underexplored. This study presents a case for it as an alternative for patients prioritizing fertility preservation prior to ART.

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This study into the relationship between hepatic fat infiltration and clinical indicators in PCOS shows the MRI HISTO sequence as an effective non-invasive and sensitive method to assess hepatic steatosis in PCOS patients, facilitating early clinical intervention.

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This study shows morphokinetic events (MKS) can be used as additional selection criteria for the transfer of embryos, helping select the best euploid embryo based on developmental history to enhance chances of successful implantation and live birth.

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The Summer 2025 edition of RBMO Digest is now available on our website.

Catch up with the biggest recent papers from the journal, with our regular round up of:
Hot Topics, Editor’s Choice, Review Articles, and more

Read it on our website, now:

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#RBMOdigest

The finding of this study show Spanish egg donors fluctuate between two interpretative registers concerning kinship: one prioritizing genetics, experiential and social factors.

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#ReproductionTechnologyAndSociety

The critical role of extracellular vesicle (EV) protein cargo as a distinctive and informative biomarker source for unravelling the complexities of unexplained infertility in women is emphasised in this new article by Raminta Vaiciuleviciute and team in Lithuania.

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This new interview-based study explores donors’ retrospective understandings of their donations, some 30 years after they began to donate.

The stories presented in this article show how the time frame in which they viewed the donations progressively expanded over time.

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Sunday bump for our annual prize winner's webinar!

Two valuable papers that make practical advances in the field, and two presentations with fascinating insights into the work behind them.

Watch it in full on the channel now.

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This new review highlights the pivotal role of aberrant DNA methylation and altered miRNA expression as independent regulators of gene expression in different PCOS tissues.

As with all RBMO Review articles, this paper is free to read, available in issue 50.1 now

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The findings of this new review suggest ffAMH could serve as a marker for granulosa cell function and a potential indicator of oocyte quality, with promise for clinical implementation as a prognostic and selection marker for oocytes.

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Catch up with the latest journal highlights and new perspectives on recent papers in the July edition of RBMO Insights.

Read it though our LinkedIn page or web-browser mailing list versions:

Mail: sh1.sendinblue.com/ahyigw55z9pf...

LinkedIn: www.linkedin.com/pulse/rbmo-i...

Offering valuable insights into the accurate application of the technique, this new study presents the first attempt to evaluate the feasibility of using non-invasive preimplantation genetic testing (niPGT) to prevent mitochondrial DNA diseases.

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This study found no correlation between serum P4 levels on the day of fresh transfer and live birth outcomes, raising questions regarding the necessity for routine P4 measurements as well as the development of rescue strategies.

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This study presents seven key factors influencing clinical pregnancy rates which could be used to inform machine learning algorithms to help predict success rates and optimise treatment strategies.

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This study finds Japanese men who engage in higher levels of physical activity and have a shorter sedentary time are associated with less sperm DNA damage.

These findings underscore the potential means to improve semen quality, specifically DNA integrity.

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