Reproductive BioMedicine Online

Administration of the oral GnRH antagonist elagolix in appropriate doses for 2 months in women with endometriosis before euploid embryo transfer yields highly encouraging outcomes that are equivalent to those achieved with parenteral administration of a GnRH agonist,

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This systematic review and meta-analysis into ovarian reserve suggests that the risk of miscarriage is significantly higher in women who underwent ART with a low AMH concentration compared to those with medium and high concentrations across all age groups.

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This study investigated the use of assisted reproductive technologies (ARTs) by trans and/or non-binary (TNB) individuals and their partners at, to understand their family-building journeys.

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This study showed that one-step warming produced comparable or better clinical outcomes than standard multi-step warming, and one-step warming was effective using brands of thawing solutions with different compositions than those reported previously

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In this retrospective study analyzing double embryo transfers (DET) with mosaic embryos, transferring two good prognosis embryos resulted in an unacceptably high rate of twin pregnancies; thus, say the authors, this type of DET should be avoided.

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The findings of this new study show that DOR patients have fewer euploid embryos but similar euploidy rates and pregnancy outcomes compared to non-DOR patients within the same age group.

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Selected by our Chief-Editors as their Editor’s Choice article from our December issue, this study explores the possible presence of comorbidities in a group of patients with only adenomyosis.

Published open access, the paper can be read in full from issue 51.6 now:

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This comprehensive review assess the risks of congenital anomalies associated with each technique of reproductive medicine – clinical or biological, along with parental factors and major congenital anomaly categories according to the mode of conception.

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This Review emphasizes the urgent need for evidence-based guidelines to streamline c conventional IVF procedures, ensuring both improved clinical outcomes and greater consistency in practice across the global landscape of ART.

Read the full Review for free from issue 52.1

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This new study from a team led by Valerie Schutyser examines the significance of these lesions on the IVF/ICSI outcomes, and adds to the debate on the efficacy of removal before embryo transfer.

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This study effectively utilized a comprehensive array of morphokinetic data to develop a multicentre machine learning model capable of differentiating between aneuploid embryos and those with the potential for live birth.

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Catch up with the February RBMO Insights.

with three new Talking Points discussing luteal support, reproduction in space, and the fate of stored embryos - plus news of our March webinar, a profile of our Experimental Reproductive Biology section, and more!

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The February issue of RBMO is out in full now with 17 Research Articles and 8 Reviews across seven of our specialist sections

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This review summarises the growing body of evidence that suggests that micro- and nanoplastics (MNPs) pose significant risks to human reproductive health, potentially affecting fertility, hormonal regulation, and fetal development.

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This new scoping review from a team in Copenhagen draws on data from the Nordic welfare states since 1970, to explore women’s and men’s parenthood intentions, their assessment of important circumstances for family building, and their fertility knowledge.

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Before we venture further into the year, we have our Winter ‘25 edition of RBMO Digest to share, rounding up notable papers from the three concluding issues of last year in a convenient collection to refer to, and share with colleagues.

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This new review from investigates the developmental, clinical and neonatal outcomes of 1PN embryos compared with 2PN embryos, and ultimately shows that monopronucleated embryos may expand the pool of embryos available for clinical use.

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This meta-analysis provides an exhaustive, comprehensive and updated view on the impact of MACS on sperm parameters and reproductive outcomes. MACS represents a promising tool in sperm selection by reducing sperm DNAf significantly, especially in patients with high DNAf.

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The findings of this study by a team at Kato Ladies Clinic, show a significant association between key morphokinetic and morphological features from fertilisation through blastulation using the deep learning–based oocyte assessment system, MAGENTA.

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Issue 45 of our monthly newsletter, RBMO Insights, is out now!

Read on for details of our next webinar in March, three new Talking Points features, new PGDIS Guidelines, event previews, article highlights and a Section Profile with Editor Roseanne Rosario

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Amy Winship and colleagues from institutes in South Australia present the results of a unique study assessing the relationship between exposure to severe prolonged bushfires and clinical ART outcomes.

Read the full paper for free from our December issue:

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We are pleased to publish a new review article which addresses a difficult but essential question for human spaceflight: how spaceflight conditions may affect reproduction, fertility, and long-term human health, and just as importantly, where the evidence is still missing.

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This study assesses the value of the Positive Reappraisal Coping Intervention to enhance emotional support and help women sustain their coping during the early waiting stages of a new pregnancy after recurrent pregnancy loss

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This proof-of-concept project trials the use of a mobile IVF laboratory to deliver mild stimulation and low-cost embryo culture to patients that would otherwise not be able to access such treatments.

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Our congratulations to all the winning authors!

In a year when we received many excellent submissions, these papers stood out as particularly accomplished works that represent impactful progress in the technology and techniques of our field and make valuable contributions to the literature.

5/5

This year’s winner and runner up will each receive award certificates, an invitation from Alpha Scientists in Reproductive Medicine to give a presentation related to their papers at the 15th Biennial ALPHA Conference, 2026, and an invitation to participate in our June RBMO Live webinar.

4/5

We are also delighted to award the Runner-Up prize to the following paper by Steven Vasilescu et al.

A biomimetic sperm selection device for routine sperm selection

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3/5

The winner of the 2025 Robert G. Edwards Prize is the following paper by Gerardo Mendizabal-Ruiz et al.:

A digitally controlled, remotely operated ICSI system: case report of the first live birth

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2/5

The editors of Reproductive BioMedicine Online are very pleased to announce the winner and runner up of our annual prize paper award for the best paper published in 2025

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1/5

This study assesses the iron levels of ovarian endometriomas and the surrounding ovarian tissue through MRI-R2* non-invasively, and to explore the short-term effect of ovarian endometrioma surgery on iron deposition.

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