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Laura Lorenzo Orts

@lorenzoorts.bsky.social

New PI @IMB in Mainz, Germany. Combining in vitro and in vivo approaches to study maternal mRNA regulation in 🐟 embryos.

383 Followers  |  376 Following  |  27 Posts  |  Joined: 16.11.2024
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Posts by Laura Lorenzo Orts (@lorenzoorts.bsky.social)

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First 24 hours of embryonic development in 9 different animal species: (From left to right) Zebrafish, Sea urchin, Black widow spider, Tardigrade, Sea squirt, Comb jelly, Parchment tube worm, Roundworm, Slipper snail. Credit to @tessamontague.bsky.social & Zuzka VavruΕ‘ovΓ‘. #ZebrafishZunday #devbio πŸ§ͺ

08.03.2026 09:50 β€” πŸ‘ 222    πŸ” 58    πŸ’¬ 3    πŸ“Œ 6
Colorful comparison of different zygote sizes from the minuscule C. elegans (50 micrometers) to the massive chick zygote (30k micrometers). Credit to Prof. Richard Behringer.

Colorful comparison of different zygote sizes from the minuscule C. elegans (50 micrometers) to the massive chick zygote (30k micrometers). Credit to Prof. Richard Behringer.

To give people a sense of the scale of these videos, check out this comparison of zygote sizes created by @rrbehringer.bsky.social πŸ§ͺ #devbio

08.03.2026 10:51 β€” πŸ‘ 44    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
Contact/Job - Department of Molecular and Cellular Biology - UNIGE

You are finishing your PhD and looking to continue in science?

The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro....

Thanks for reposting!

03.03.2026 09:42 β€” πŸ‘ 58    πŸ” 73    πŸ’¬ 1    πŸ“Œ 2
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Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here:
mbg.au.dk/en/news-and-...

06.03.2026 07:47 β€” πŸ‘ 20    πŸ” 28    πŸ’¬ 0    πŸ“Œ 0
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Exciting news:
Our RNA community in @uniregensburg.bsky.social is set to grow!

We are opening a Junior Group Leader position in RNA biochemistry / ribonucleases / RNA stability. A great opportunity to start your own team within our collaborative RNA network.

Details & application πŸ‘‡

04.03.2026 12:21 β€” πŸ‘ 17    πŸ” 22    πŸ’¬ 1    πŸ“Œ 1

✨ New postdoctoral opportunity in #cell biology at UNIGE!
@sophiemartinlab.bsky.social is looking for a postdoc to study cell–cell fusion.
Spread the word and see details below πŸ‘‡@mocel.bsky.social @sciencesunige.bsky.socia

05.03.2026 10:01 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Join us in Vienna for the biggest international 'FISH' meeting in 2026! No matter which fish is your favorite model - zebrafish, medaka, killifish, cavefish, Danionella, cichlids, stickleback, you name them...- this meeting is for you!

www.ezm2026.org

Abstract submission deadline is March 15th.

23.02.2026 20:06 β€” πŸ‘ 27    πŸ” 16    πŸ’¬ 3    πŸ“Œ 3
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Really happy to see this one out: www.sciencedirect.com/science/arti... Alibek's drive & great coll w/ friends @gekaragoz.bsky.social & E. Hallacli resulted in a cool story that starts with our beloved #Marchantia and ends with iPSC-derived neurons 🀩πŸ€ͺ A short 🧡

23.02.2026 17:05 β€” πŸ‘ 119    πŸ” 53    πŸ’¬ 6    πŸ“Œ 7

Weβ€˜re looking for a motivated Master student to join our team!

Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? πŸ’‘πŸ§«πŸ§¬πŸ”¬

Then please apply!
#optogenetics #metabolism #devbio #hESCs

Please RT. Thank you!πŸ™

17.02.2026 18:21 β€” πŸ‘ 38    πŸ” 39    πŸ’¬ 0    πŸ“Œ 0
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Max Fels @mfels.bsky.social from our lab discovers giant DNA viruses that infect amoeba encode eIF4E and the entire suite of 4F complex proteins to control mRNA translation, including beautiful crystal structures of viral 4E bound to modified mRNA 5' caps:

www.cell.com/cell/fulltex...

17.02.2026 18:17 β€” πŸ‘ 92    πŸ” 36    πŸ’¬ 1    πŸ“Œ 3

The demystification of piRNA clusters

if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read

check out @86dominik.bsky.social's opus magna (or Dominik's great thread)

a shared project with the one and only Rippei Hayashi, lab alumnus & friend

13.02.2026 20:39 β€” πŸ‘ 41    πŸ” 18    πŸ’¬ 2    πŸ“Œ 1
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A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
1/n

13.02.2026 11:42 β€” πŸ‘ 497    πŸ” 209    πŸ’¬ 10    πŸ“Œ 28
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🚨 Positions available in Plant Science! Please share. We’re hiring:
1. Postdoc
2.PhD (UK applicants only)
Focus: root oxygen dynamics, developmental signalling. Come help us uncover how O2 shapes root development.
More info here-
sites.google.com/view/root-re...
#plantscijobs #plantscience

11.02.2026 15:19 β€” πŸ‘ 27    πŸ” 38    πŸ’¬ 0    πŸ“Œ 0

And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...

11.02.2026 17:12 β€” πŸ‘ 41    πŸ” 21    πŸ’¬ 1    πŸ“Œ 0
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Ulrich’s research will help advance our understanding of RNA biology & gene regulation, as well as how these mechanisms might be altered during viral infections & other diseases.
@hohmannulrich.bsky.social comes from the @impvienna.bsky.social / @imbavienna.bsky.social

www.imb.de/about-imb/ne...

09.02.2026 11:14 β€” πŸ‘ 40    πŸ” 16    πŸ’¬ 1    πŸ“Œ 1

😎 paper alert!

Nice work from the Laub lab showing that binding to ring structures made by different phage defense proteins activates RNAse to inhibits translation and phage infection. It needs to be in a 24-meric ring structure to cut.

πŸ§ͺ#microsky

06.02.2026 09:50 β€” πŸ‘ 6    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Really excited to join IMB for this new scientific endeavour!

06.02.2026 14:49 β€” πŸ‘ 34    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0
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Please share!
My group at @zmbp-tuebingen.bsky.social is offering a post-doctoral position (4 years). We look for a structural biologist with experience in Cryo-EM/Cryo-ET to investigate the mechanisms of host invasion by pathogenic fungi. Deadline February 28th!
uni-tuebingen.de/universitaet...

30.01.2026 13:56 β€” πŸ‘ 83    πŸ” 118    πŸ’¬ 0    πŸ“Œ 3
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Pre-assembly of biomolecular condensate seeds drives RSV replication Nature - Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake!

rdcu.be/e1bBW

28.01.2026 20:38 β€” πŸ‘ 91    πŸ” 35    πŸ’¬ 1    πŸ“Œ 2
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Formation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells!
Read our paper @cp-cell.bsky.social!

❕Publication: doi.org/10.1016/j.ce...
❕Press Release: www.biochem.mpg.de/en/pressroom

@uoftmedicine.bsky.social
@erc.europa.eu #UPSmeetMet

28.01.2026 16:39 β€” πŸ‘ 69    πŸ” 26    πŸ’¬ 0    πŸ“Œ 2
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Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development Zygotic genome activation (ZGA) failure leads to developmental arrest and poses a clinical challenge to women’s fertility. We observed that human embryos arresting at the eight-cell ZGA stage exhibite...

New findings in Science offer insight into why some embryos fail to develop past zygotic genome activation, pointing to an unexpected root of human infertility.

Learn more: https://scim.ag/46cc4WI

28.01.2026 20:52 β€” πŸ‘ 38    πŸ” 7    πŸ’¬ 1    πŸ“Œ 0
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I’m happy to share the main result of my PhD, which you can find on bioRxiv www.biorxiv.org/content/10.6.... If you are interested in learning about a new way to perform DNA-PAINT multiplexing, which we call Combi-PAINT, or if you are interested in the study of mRNA conformation, keep reading! 1/10

26.01.2026 11:31 β€” πŸ‘ 74    πŸ” 26    πŸ’¬ 3    πŸ“Œ 5
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🐟 Exciting News! 🐟 1st German Fish Model Research Meeting :
πŸ”— Submit your abstract and register today: www.germanfishmeeting.org

πŸ“… When: September 16–18, 2026
πŸ“ Where: Center for Organismal Studies, Heidelberg, Germany

#germanfishmeeting2026 #fish #research #zebrafish #science

09.01.2026 12:55 β€” πŸ‘ 2    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1
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Excited to share our new paper! We developed a method to visualize proteasomal degradation at the single–molecule level in live cells, enabling us to dissect distinct modes of substrate engagement, probe co-factor dependence, and study proteasome–ribosome collisions.
www.biorxiv.org/content/10.6...

20.01.2026 12:27 β€” πŸ‘ 48    πŸ” 15    πŸ’¬ 1    πŸ“Œ 1
In vivo kinetics of protein degradation by individual proteasomes Protein degradation by the proteasome is central to cellular homeostasis and has been studied extensively using biochemical and structural studies. Despite an in-depth understanding of core proteolytic activity, it has remained largely unresolved how individual proteasomes process substrates inside living cells where many substrate types and co-factors exist. Here, we establish a live-cell single-molecule imaging approach that enables direct visualization and quantification of protein degradation by individual proteasomes. Using this approach, we find that substrate identity, folding and protein-protein interaction have a surprisingly modest impact on processing efficiency, whereas the mode of substrate engagement greatly impacts substrate processing; degradation initiated from protein termini typically proceeds rapidly and with high processivity, whereas internal engagement constitutes a distinct processing mode that exhibits poor processivity and a specific requirement for the AAA+ family ATPase p97/VCP. Furthermore, degradation initiated from opposite termini proceeds with asymmetric rates in a sequence-dependent manner, demonstrating that directionality is an important feature of proteasomal processing in vivo. Notably, poly-glutamine substrates associated with neurodegenerative disease are efficiently degraded from one terminus but resist degradation when engaged from the opposite terminus, highlighting the importance of substrate engagement mode. Together, our results show that different modes of substrate engagement lead to different proteasomal processing outcomes in vivo and revise the prevailing view of the proteasome as a uniform degradation machine. ### Competing Interest Statement The authors have declared no competing interest.

New lab paper!! We develop a technology for real-time, single-molecule visualization of proteasomal substrate degradation in cells. We find that the site of substrate engagement by the proteasome determines decay kinetics, efficiency and co-factor requirement.

www.biorxiv.org/content/10.6...

20.01.2026 08:32 β€” πŸ‘ 47    πŸ” 15    πŸ’¬ 1    πŸ“Œ 2
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Discuss #RNA 3' ends and their regulation at the EMBO Workshop "RNA 3' ends and beyond" in #Oxford, United Kingdom, 7–11 September 2026.

Deadline: 4 May 2026

https://meetings.embo.org/event/26-rna3
#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents πŸ§ͺ

20.01.2026 15:30 β€” πŸ‘ 18    πŸ” 14    πŸ’¬ 0    πŸ“Œ 1
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AlphaFold protein interaction modeling tutorial and workshop - the Node This video is the culmination of several years attempting to: (1) Figure out best practices for modeling protein-protein interactions; (2) Understand the This video is the culmination of several years...

AlphaFold protein interaction modeling tutorial and workshop thenode.biologists.com/https-www-yo...

18.01.2026 16:36 β€” πŸ‘ 35    πŸ” 10    πŸ’¬ 0    πŸ“Œ 0
SLBP-independent control of maternal histone mRNA Replication-dependent (RD) histones are crucial for packaging newly replicated DNA into chromatin, ensuring genome stability. In metazoans, the mRNA of RD histones is uniquely regulated through a conserved 3β€² stem–loop bound by stem–loop binding protein (SLBP). This allows cell cycle-coupled regulation of these important transcripts. However, oocytes must stabilise histone mRNAs independently of the cell cycle to ensure maternal loading to support the first embryonic divisions. Using Caenorhabditis elegans as a model system, we discovered an SLBP-independent mechanism that ensures RD histone transcript stability during oogenesis. This is mediated by the protein complex PETISCO, bound to the effector protein TOST-1, which directly binds the histone stem–loop region and maintains maternal histone mRNA levels during oogenesis and early embryogenesis. Loss of this mechanism disrupts histone homeostasis, leading to premature genome activation, mitotic defects, and embryonic lethality. Interestingly, the same complex, PETISCO, acts in piRNA biogenesis when bound to the effector PID-1, revealing an intriguing co-option of this histone mRNA homeostasis mechanism by the piRNA pathway. Our findings reveal a unique SLBP-independent mechanism of histone mRNA regulation, that served as a basis for the evolution of a novel piRNA biogenesis mechanism. ### Competing Interest Statement The authors have declared no competing interest. Deutsche Forschungsgemeinschaft, https://ror.org/018mejw64, 407023052, 439669440, 252386272, 504320275 FWF Austrian Science Fund, https://ror.org/013tf3c58, I6110-B

check this beauty from @reneketting.bsky.social @koenig-lab.bsky.social and co

www.biorxiv.org/content/10.6...

20.01.2026 20:07 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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A genetically encoded device for transcriptome storage in mammalian cells Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

πŸ§¬πŸ”¬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org

15.01.2026 20:30 β€” πŸ‘ 55    πŸ” 25    πŸ’¬ 1    πŸ“Œ 3
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The (Yoav) Voichek lab has opened its gates at the Weizmann Institute, and is actively recruiting students and researchers at all levels - come explore gene regulation and computational genomics in a fun, friendly sprouting lab πŸ€—πŸ₯Όβš—️πŸ§ͺ
www.weizmann.ac.il/plants/voichek

11.01.2026 20:41 β€” πŸ‘ 44    πŸ” 32    πŸ’¬ 0    πŸ“Œ 0