Renato Ostuni

Connection and communication between the nervous and immune systems - Nature Reviews Immunology Here, Swirski and colleagues explore how the nervous and immune systems connect and collaborate to respond to internal and external stimuli. In particular, they consider how the exchange of informatio...

Very happy to share this Perspective in @natrevimmunol.nature.com

www.nature.com/articles/s41...

Allenare il sistema immunitario: la scienza dell'(ultra)running - Italian Outdoor Festival Tutti sappiamo che l'esercizio fisico “fa bene”, ma in che modo, e perché? Come e fino a che punto possiamo allenare il nostro sistema immunitario? Ne discutono due scienziati-atleti (Renato Ostuni e ...

See you at Italian Outdoor Festival this Sunday!

Will speak with Dylan Liabeuf (berlin-barcelona.com) and ultrarunning legend Filippo Canetta about #immunology #running #exercise #Wellness #scicomm

🏠 @unisr.bsky.social, SR-Tiget, San Raffaele

italianoutdoorfestival.com/event-item/a...

Congrats!!!

Review @cp-trendsimmuno.bsky.social @ostunilab.bsky.social
IL-1β+ macrophages and the control of pathogenic inflammation in cancer
www.cell.com/trends/immun...

and here's the Sharelink with full access: authors.elsevier.com/a/1ks7s5Eb0R...

IL-1β+ macrophages and the control of pathogenic inflammation in cancer While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated macrophages (TAMs). Among these, interleukin (IL)-1β+ TAMs – cells with high levels of expression of inflammatory response and tissue repair genes, but with limited capacity to stimulate cytotoxic immunity – are emerging as key drivers of pathogenic inflammation in cancer. In this review we discuss recent literature defining the phenotypical, molecular, and functional properties of IL-1β+ TAMs, as well as their temporal dynamics and spatial organization. Elucidating the biology of these cells across tumor initiation, progression, metastasis, and therapy could inform the design and interpretation of clinical trials targeting IL-1β and/or other inflammatory factors in cancer immunotherapy.

IL-1β+ macrophages and the control of pathogenic inflammation in cancer #immunology

IL-1β+ macrophages and the control of pathogenic inflammation in cancer While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated mac...

#MustRead. For #TumorImminologyLovers & more, check this fantastic review @ostunilab.bsky.social &co @cp-trendsimmuno.bsky.social all about #IL1 from #macrophages & pathogenic #inflammation in #cancer. #ScienceMatters dlvr.it/TJslPb

IL-1β+ macrophages and the control of pathogenic inflammation in cancer While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated mac...

Happy to share our reflections @cp-trendsimmuno.bsky.social on our favourite cells: IL-1β+ macrophages 🔥🔥🔥
Molecular, spatial, temporal, functional properties in cancer and beyond... it's all in there from the awesome Nicoletta Caronni, Federica La Terza and @frosio.bsky.social

tiny.cc/y94f001

Sign the Petition Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

chng.it/kK2HMP5pGk

More on the role of IL-1 inflammation in TME... Deletion of TREM2 in pancreatic cancer unexpectedly accelerates disease progression due to secondary increase of pathogenic IL-1b+ TAMs 🔥🔥🔥

www.gastrojournal.org/article/S001...

Congrats to all award recipients from our meeting, T Cell Differentiation in Tissue Microenvironments/Innate Immune Memory! #KSTCells25 #KSInnateImmune25 @ostunilab.bsky.social @delgoffelab.bsky.social @thelundlab.bsky.social @drshrutinaik.bsky.social @labfairfax.bsky.social @ostunilab.bsky.social

Last week in Vancouver was wild—my first time overseas didn’t disappoint ❄️. Got chills sharing our work on IFN regulation and seeing it finally go international 🦠. So thankful to the organizers and to who is making the dream possible @ostunilab.bsky.social @keystonesymposia.bsky.social

Shout out to this group of inspiring scientists! One of the best keystones hands down. Wishing everyone safe travels back. So grateful for the scholarship and a chance to share my work.

We're in the endgame now with Dr. Maz Divangahi wrapping up amazing joint 3d memory meeting #KSinnateimmune25 #KSTcells25. Thx to the organizers @drshrutinaik.bsky.social @labfairfax.bsky.social @ostunilab.bsky.social @nikjoshilabyale.bsky.social @thelundlab.bsky.social @delgoffelab.bsky.social 👏👏

Amazing kickoff by Yasmine Belkaid keynote on the role of immunity in pregnancy and lactation @keystonesymposia.bsky.social #KSinnateimmune25

And here is a pretty picture of a dendritic cell to get us started 😀.

Happy New Year! I am a newly-arrived refugee from the other platform. Looking forward to (re-)connecting with friends and colleagues in this community!

The science of pasta cacio e pepe 🇮🇹👨‍🍳

Catch @drshrutinaik.bsky.social, @labfairfax.bsky.social, @ostunilab.bsky.social and Yasmine Belkaid for Innate Immune Memory. Submit your abstract for a poster presentation spot by Jan. 9th (11:59pm MST)! keysym.us/KSInnateImmu... #KSInnateImmune25 #keystoneconferences #innateimmunity

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.

Crazy hot stuff by Magali Irla @ciml.bsky.social - RANKL treatment reverts thymic involution and boosts T cell function in aged mice

www.science.org/doi/10.1126/...

Coffee in Naples really is something else 💚

Congrats!!!! Happy to see it out 🎉🎉🎉

Fantastic study (and thread👇) by the awesome @obenaufa.bsky.social lab!!! Cancer cells shut down antigen cross-dressing and T cell activation via PGE2 @natureportfolio.bsky.social

A grant reviewer praised our use of multi-comic* approaches and I think it's the best typo I've ever seen😍

Our very own Luca Frosio using Mr Bean to pitch his 🔥 discoveries on IFN regulation in macrophages - stay tuned!!!

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity Hänggi et al. investigate how tumor necroptosis regulates anti-tumor immunity and find an unexpected role for interleukin-1α (IL-1α) release by dying cells in promoting tumor growth by driving recruit...

IL-1 is SO RELEVANT in cancer 🔥 IL-1a released from dying tumor cells leads to myeloid cell recruitment and T cell suppression - targeting this pathway boosts efficacy of chemoTx and ICB

Beautiful study by @ruffell-lab.bsky.social lab n Cancer Cell

www.cell.com/cancer-cell/...

With the deluge of new friends - if you are or know someone who is a looking for a position as computational scientist (any level) in #pancreaticcancer, #macrophages #spatialbiology #singlecell... we might have something for you. Will also consider wet lab ppl, send email if interested. pls repost!

Very excited to share our latest work on the uncoupling of epithelial regeneration and tumorigenesis in the gut! nature.com/articles/s41...

#teamneutrophils