Deep-water man.
09.06.2025 16:12 β π 1 π 0 π¬ 0 π 0@budluddy.bsky.social
Scientist, artist, naive believer that there is still some kind in humankind. Biochemistry is life. Neuromelanin is functional in human brain, and so are glutamate polymers. We call the latter 'chlorophyll' in plants. DNA is mitochondrial poop. Fight me.
Deep-water man.
09.06.2025 16:12 β π 1 π 0 π¬ 0 π 0#tariffs #heardmarshallislands
04.04.2025 22:08 β π 842 π 194 π¬ 40 π 14yes :(
27.03.2025 20:41 β π 0 π 0 π¬ 0 π 0These turned out alright! Wood and dyed acrylic epoxy polymer. Goofing around with some ideas. Desperately trying to maintain some measure of sanity.
12.03.2025 17:50 β π 2 π 0 π¬ 0 π 0"One can imagine their outrage had a Democrat expressed such views." www.liberalcurrents.com/the-suicide-...
12.03.2025 01:28 β π 47 π 11 π¬ 2 π 2He that is without sin among you, let him be the first to cast a stone. I mean, who among us doesn't have 30 or 40 felony convictions, amiright??
11.03.2025 06:15 β π 0 π 0 π¬ 0 π 0This is not a test. We repeat, this is NOT a test.
09.03.2025 05:52 β π 1 π 0 π¬ 0 π 0Anyway, that's a small introduction to me and what I've been thinking about for the last 20+ years. I intend to keep my bsky account positive and leave my political protests on Zuck's sinking ship. You'll see my art and any science I find interesting and notable. (5/5)
08.03.2025 17:37 β π 0 π 0 π¬ 0 π 0Again, the big deal here is that the molecules that 'go bad' in these diseases ARE NOT gene products. We'll never find 'a' gene for them, only ~7% of PD cases have a known genetic basis, all related to melanin disposition, mitochondrial dysfunction, or inflammation. pubmed.ncbi.nlm.nih.gov/28469642/
08.03.2025 17:34 β π 0 π 0 π¬ 0 π 0These polymers are foreign to the immune system and releasing them triggers inflammation. In PD, melanized dopaminergic neurons leak polymer leading to an autoimmune cascade and eventual diseased state. I'm including a link to my hypothesis paper (>100 citations) on PD. Alzheimer's is similar (3?/?)
08.03.2025 17:31 β π 0 π 0 π¬ 0 π 0Glutamate and dopamine are distinctly different molecules. Yet behave in similar ways. In particular, when you have enough molecules ('monomers'), they react to form polymers--melanin from dopamine, and what we call 'chlorophylls' from glutamate. Both form heme-like, metal binding domains. (2/?)
08.03.2025 17:24 β π 1 π 0 π¬ 0 π 0Why Alzheimer's and Parkinson's mysteries have been so difficult to solve boils down to one simple fact: the deficiency is a pure chemistry one. That is, the molecular process underlying both diseases is a functional macromolecule that is NOT the product of a gene or genes. (1/?)
08.03.2025 17:20 β π 0 π 0 π¬ 0 π 0I got a similar notice on FB for my wood and glass art. I'm ignoring it, the notice is very suspect imho.
06.03.2025 22:42 β π 0 π 0 π¬ 0 π 0(sigh) I retired early from teaching as the pandemic really made it intolerable. I did my best to make a career out of science and want to write my book. But knowing it would just go out into empty space is really discouraging.
03.03.2025 18:32 β π 0 π 0 π¬ 0 π 0I daresay we won't be seeing 'The Art of Diplomacy' in print anytime soon.
01.03.2025 00:56 β π 0 π 0 π¬ 0 π 0They completely bought into the 5K carrot.
01.03.2025 00:49 β π 0 π 0 π¬ 0 π 0I tried to sign up but was denied as I do not have an academic affiliation. I have a strong publication record though.
26.02.2025 14:31 β π 1 π 0 π¬ 1 π 0I'd love to, but I see recently retired won't work. Bummer.
26.02.2025 04:17 β π 1 π 0 π¬ 1 π 0Prototype in progress. Seems I need to find my anti-static stuff--that acrylic really attracts the dust, eh??!
09.02.2025 23:52 β π 6 π 0 π¬ 0 π 0New supplies:
05.02.2025 18:34 β π 2 π 0 π¬ 0 π 0Desperately trying to stay sane by keeping busy. There was a hiccup with one of our guest artists for this coming year--a woodworker who I was excited about, turns out was unable to attend the reception. A solution was put forth: Have a 'Three Woodsmen' show, me being one of them. Show idea piece.
01.02.2025 07:58 β π 3 π 0 π¬ 1 π 0New, perhaps temporary until I get more creative, business cards out at the gallery. Merry Christmas!
11.12.2024 21:44 β π 1 π 0 π¬ 0 π 0