Guichard-Lab

Congrats @radha-tomar.bsky.social for winning the poster prize at the International Symposium on #foldamers 2025 🎉👏
Huge thanks to @andrecobb.bsky.social for organizing such an inspiring meeting at King’s College London! Great science & good vibes!
@foldnetuk.bsky.social @iecb.bsky.social

That’s a wrap! Huge thanks to our speakers, poster presenters, attendees, sponsors, organisers, @andrecobb.bsky.social, @anbismillah.bsky.social, @kingsnmes.bsky.social, EPSRC @ukri.org

See you at the next #Foldamers meeting in 2027 in Budapest at HUN-REN Research Centre for Natural Sciences

Bravo ! 👏👏

Definitely planning to attend - Looking forward to reconnecting with the foldamer community in London !

Great to see our paper on helicity-dependent peptide cyclizations online at the Journal of Peptide Science doi.org/10.1002/psc.... (open access)

Congrats to all authors!! #peptidomimetics

Really enjoyed the Korean BBQ with colleagues and friends Prof. Hee-Seung Lee from KAIST and Prof. Sung Hyun Yoo from Chonnam National University yesterday after a full day at the KCS meeting. Great food and great company!

Excited to join 2025 Korean Chemical Society 135th General Meeting &Exhibition this week! Always a pleasure to catch up with colleagues and reconnect with lab alumni. Thank you, Sung Hyun @yoo-bios-lab.bsky.social for the fantastic welcome in Korea — truly appreciated!
@iecb.bsky.social
#ChemSky

We are recruiting 🤩🤩🤩!!! If you are looking to establish ylur lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, apply!!!

Join us this Friday, April 4th, for an afternoon minisymposium on protein structure and dynamics in disease! The place is as usual our IECB amphitheater!

What a superb and inspiring day, discussing highly diverse aspects of #Bioinspiration - A big thank to all the speakers, chairpersons, and the attendance. As well as the people involved in the organization...

Advances in Bioinspirations

@inserm.fr - @cea.fr - @cnrs.fr

#BMSV

Congratulations to Maxime, Mathieu, Claire, Jérémie, Bo, Isabel, Laetitia and Morgane for their key contributions and special thanks to our collaborators : Brice @bkauffmann.bsky.social Emmanuelle @thinonlab.bsky.social and Majid Khatib @departementsbm.bsky.social 👏✨

Co-crystal structure of a macrocyclic foldamer-peptide hybrid (8a) bound to hDM2 (PDB ID 9GFK)

See our latest work on stapled peptide-foldamer hybrids targeting hDM2, using cis-4-mercaptoproline for an optimal macrocyclization. 🚀
@iecb.bsky.social @cnrsaquitaine.bsky.social @univbordeaux.bsky.social @departementsts.bsky.social
#ChemBio #ChemSky
Read more: doi.org/10.1002/chem...

Congratulations to Chloé Freyermuth on successfully defending her PhD! 🎉 I'm really proud to have her as the first PhD student in the lab @iecb.bsky.social @CBMN

A huge thank you to the members of the jury: Laurence Abrami, Agnès Rötig, Ed Tate, @ffriscourt.bsky.social, @guichard-lab.bsky.social

Congratulations to Jason Zhu on the publication of his manuscript "A β-Hairpin Peptide Derived from Aβ Forms Different Oligomers in the Crystal State and in Aqueous Solution" in Organic and Biomolecular Chemistry: pubs.rsc.org/en/content/a.... This

Stabilization of a miniprotein fold by an unpuckered proline surrogate Communications Chemistry, Published online: 12 March 2025; doi:10.1038/s42004-025-01474-6Proline plays an important role in mediating protein folding and stability, however, the impact of noncanonical proline analogues on protein folding and stability is…

Just out: Stabilization of a miniprotein fold by an unpuckered proline surrogate

DNA Mimic Foldamer Recognition of a Chromosomal Protein Biomolecular mimics are intended to outperform their natural counterparts. However, B-DNA surface mimicry to target DNA-binding proteins has long remained underdeveloped. We have introduced helical a...

Please check out our Angew. communication on DNA mimic foldamers that can outcompete DNA itself in the binding of proteins! 🧬

onlinelibrary.wiley.com/doi/full/10....

It was such a pleasure and privilege to have Prof Sabine Flitsch from Manchester university presenting today at our IECB seminar series @iecb.bsky.social @univbordeaux.bsky.social @departementsts.bsky.social

Join us next week on Friday the 7th, at 11 am, in our IECB amphitheater to learn a whole lot on the design and applications of enzyme cascades for organic synthesis 🤓🧪👩‍🔬⚗️! Guest speaker Prof. Sabine Flitsch from the University of Manchester 🤩!!!

www.iecb.u-bordeaux.fr/evenements/i...

Great collaboration with our colleagues Natacha Rochel at IGBMC, Gavin Collie @astrazeneca.bsky.social, and Brice Kauffmann @bkauffmann.bsky.social that made this work possible! 👏✨
#ChemBio #ChemSky

Guanidinium‐Stapled Helical Peptides for Targeting Protein‐Protein Interactions Peptide stapling has emerged as a versatile approach in drug discovery to reinforce secondary structure elements especially α-helices and improve properties of linear…

Happy to share our work on guanidinium-stapled peptides, now published in @angewandtechemie.bsky.social! A versatile method to stabilize peptide helices for precise protein surface recognition. Congrats to the team and special thanks to Morgane Pasco! 👏
🔗 doi.org/10.1002/anie...
@iecb.bsky.social

Graph of annual FDA approvals

2024 FDA approvals nature.com/articles/d41...

The FDA approved 50 new therapeutics in 2024, with green lights for a novel schizophrenia drug, a first MASH medicine and much more - find out about them in our annual round-up

Happy New Year, ChemBio community! 🎉 In 2025, let’s advance chemical biology together: mobility grants to foster collaborations, training & mentoring for young scientists, and join us in Nantes (June 6-8) for our annual meeting. Free to join, spread the word! #GDRChemBio #ChemBio

Sir J. Fraser Stoddart

Sir J. Fraser Stoddart, Chair Professor in Chemistry at the University of Hong Kong, died Dec. 30, 2024, at the age of 82. He was on holiday in Australia with his family. cen.acs.org/people/obitu... #chemsky

Check out our article in @angewandtechemie.bsky.social about the design of foldamers that aggregate into abiotic quaternary structures 🧩 Congrats to Shuhe! onlinelibrary.wiley.com/doi/10.1002/...

Great to see so many familiar & new faces here!
Read on our biomimetic design strategies: www.thieme-connect.com/products/ejo...
👉 #proteomimetics for challenging targets
👉 #INCYPRO chemical #proteinengineering
👉 covalent #peptidomimetics inhibitors
Big thanks to all former & present group members!

Congratulations to our @iecb.bsky.social and MFP colleague Nicolas Reyes for his medal from the French académie des sciences (médaille de la section de Biologie moléculaire et cellulaire, génomique).
@univbordeaux.bsky.social @cnrs.bsky.social

Great to meet the #chembio community from Bordeaux (France) for the Chemistry Biology Interface Day (CBID 2024) today!
Congratulations to Cléo Chidaine (ARNA) and Melissa Kosovari (CBMN) on winning the poster prizes!
Thanks to @univbordeaux.bsky.social and @iecb.bsky.social for sponsoring/hosting

Join us next Thursday (Nov 21) for our 'Membrane-Interacting Peptides & Multiscale Biophysics' symposium organized in honor of Dr. Frances Separovic from the University of Melbourne and her award of the title Doctor Honoris Causa from the University of Bordeaux 👏👏👏!

Join us next Wednesday at our IECB amphitheater for a fantastic line-up of speakers aspiring to join our IECB faculty 👏👏👏!

If you are in our corner next week, come and join us for the first Ambassador's Tour Seminar in Chemical Sciences by Professor Ayyalusamy Ramamoorthy from Florida State University 🧪⚗️!!!

Where 🤩? At our IECB amphitheater
When 🤓? Tuesday, Nov 12th, 11 AM