JMCC Plus

YAP/TAZ deletion in vascular smooth muscle cells mirrors atherosclerosis-associated transcriptional programs The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeo…

New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology

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#CardioSky

Deletion of CHOP in beta cell protects mice from cardiovascular complications in type 2 diabetes: evidence from a pre-clinical mouse model Cardiovascular complications are the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D), which is recognized as a major i…

We often treat #diabetes and #heart #disease separately — but they’re connected🫀.

A recent study from Srinivas, Alluri et al. shows that removing CHOP in β-cells protects against both metabolic dysfunction and cardiac fibrosis in T2D mice.

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#CardioSky #NewPaper

Age, sex, and vessel region affect the vasomotor function and gene expression signature of the aorta in mice Vascular aging is associated with endothelial dysfunction, changes in vascular elasticity or stiffness, and the prevalence of cardiovascular diseases.…

🫀 New in JMCC Plus!

Age, sex & vessel region shape vasomotor function in the descending thoracic #aorta — with #endothelial integrity & relaxation declining with age.

Want to know more- check out Saemann et al.:

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#CardioSky @jmccardiology.bsky.social

Quantification of morphological, functional, and biochemical features of H9c2 rat cardiomyoblast retinoic acid differentiation Cell culture models enable advancement in our understanding of heart development and heart disease. The H9c2 rat ventricular cardiomyoblast cell line …

New work from Nicole S. York and the group of Leigh Anne Swayne at the University of Victoria charts how #H9c2 heart cells change shape, signal, & express genes during differentiation—revealing both their promise & limits as #cardiomyocyte models.

#CardioSky

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Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy The clustering of L-type calcium channels for functional regulation of intracellular calcium signaling remains poorly understood. Here we applied supe…

Ever wondered how #Calcium channels cluster in #iPSC derived #Cardiomyocytes?

New work just published from Schwenzer et al. should put your mind at rest as they investigated just that!

Check out the latest paper for more information

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#CardioSky

Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner Both Nav1.5 and Cx43 are critical for the fast electrical impulse conduction in the myocardium and their reductions create the arrhythmogenic substrat…

Looking for some weekend reading? 📜

New work from from the University of Ottawa Heart Institute, show how metabolic substrates regulate effects of Wnt/β-catenin signaling in #cardiomyocytes, specifically affecting regulation of #Connexin43

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Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation Women are under-represented in cardiovascular research, leading to poorer outcomes. Investigating sex-differences in electromechanical function is ess…

New work out in the from @ox.ac.uk looks into developing sex-specific human ventricular #electromechanical multiscale models. Given the importance of #biologicalsex in #CardiovascularHealth this could be a very important tool!

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#CardioSky

🧬 New pig models of neonatal #HCM show severe cardiac #hypertrophy and perinatal lethality from MYBPC3 and MYH7 mutations.
Pigs were highly sensitive to sarcomeric gene disruption, developing severe HCM, suggesting they may not be ideal genetic models.
🔗 www.sciencedirect.com/science/arti...

12-week-old #ob/ob mice show mild DCM with no major structural changes in #MAMs.
Proteins linked to lipid metabolism and stress response were increased in MAMs, while hypoxic stress triggered more cardiomyocyte death.

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Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart Heart failure (HF) remains a clinical challenge with cardiac dysfunction typically progressing even with treatment, and heart transplants only availab…

New paper out in our September issue from
Bass-Stringer and colleagues @bakerresearchau.bsky.social
looking at PI3K.

Exploring a new #genetherapy to improve heart function in mice and sheep.

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#CardioSky

Calling all #immunofluorescence scientists! Teng et al. showed glyoxal enhances IF signal and co-localisation while reducing staining artifacts, making it a superior alternative to PFA in murine cardiac tissue research.

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📈 Circulating adropin is linked to higher risk of #AKI in patients with acutely decompensated #heartfailure (#ADHF) after decongestive therapy.
It outperformed conventional biomarkers like urinary ACR and NT-proBNP.
#CardioRenal #Biomarkers

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Kazantzi et al show that #MEK–ERK1/2 and #PKC pathways independently and synergistically modulate ETB receptor upregulation under flow cessation. These signalling axes may be promising targets for #cerebrovascular disease.

Read more here! www.sciencedirect.com/science/arti...

Disruption of ventricular activation by subthreshold delayed afterdepolarizations in RyR2-R420Q catecholaminergic polymorphic ventricular tachycardia Catecholaminergic polymorphic ventricular tachycardia (CPVT) carries increased risk of ventricular arrhythmias due to altered Ca2+ regulation associat…

New work just out from Fowler et al, invesigated the role of subthreshold #DADs on arrhythmia generation in #CPVT!

Congrats to the Authors!

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#CardioSky

NIH-funded and need to publish in an open-access journal? JMCC Plus is fully OA and we're offering a 50% APC discount until 30 Sept 2025! Submit your work and join our growing community of cardiovascular researchers. #OpenAccess #Cardiac #Research

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New in JMCC Plus: This study presents a multidimensional analysis to investigate culture-induced alterations in living #myocardial slices, demonstrating structural integrity despite changes to slices’ functional and #molecular profiles

Read more here! www.sciencedirect.com/science/arti...

Exciting news! Clarivate has released the inaugural #ImpactFactor for 2024, and JMCC Plus, just 3 years since its launch, has earned a spot in Q2! A huge thank you to our authors, reviewers, and readers for helping us reach this milestone. #AcademicPublishing #JMCCPlus

Heart failure alters organelle dynamics. Latchman et al. reveal striking shifts in failing cardiomyocytes- more rounded #mitochondria, disrupted SR-mitochondria juxtaposition and altered lipid droplet size across #heart #failure types .
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‪@upenn.edu @temple.edu‬

New #CardioBreakthrough: Gemfibrozil—beyond lipid-lowering—blocks caspase‑11‑driven pyroptosis in mouse hearts, reducing infarct size during ischemia/reperfusion. A promising repurposed therapy post-#AMI! Congratulations to all authors.

Want to know more?

SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice Mitochondrial dysfunction with decreased ATP production and increased release of reactive oxygen species (ROS) is a hallmark of the failing heart. Alt…

Looking for some weekend reading?

We recently published some work from Chambers et al. looking at the effect of an #SGLT2i on #mitochondrial function from non-diabetic mice with #Cardiomyopathy

Accompanied by a very nice editorial!

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Performance horses as a model for exercise-associated cardiac arrhythmias and sudden cardiac death This paper reviews the myocardial substrate of horses relative to that of humans and discusses the utility of performance horses as a model of exercis…

Are you looking for a new model of arrhythmia?
Maybe performance horses are the answer!
Great work just out from Avison et al!

www.sciencedirect.com/science/arti...

The JMCC and JMCC Plus Reception is in full swing at #ISHR World Congress 2025! A great opportunity to bring our editorial team and reviewers together, while hearing from JMCC #EiC Rong Tian and JMCC Plus #EiC @davorpavlovic.bsky.social

The 25th World Congress of #ISHR 2025 in Nara, Japan, has officially begun with over 1000 members attending! A fantastic start to the conference, welcomed by traditional Japanese music, before hearing from this years' ISHR awardees.
@ishr-aus.bsky.social

PP2A-B56α is a key determinant of cardiac protein phosphorylation and functional responses to β-adrenergic signalling B56α is a protein phosphatase 2 A (PP2A) regulatory subunit which modulates the heart's inotropic response to acute β-adrenergic receptor (β-AR) stimu…

Looking for some weekend reading or on your way to the
ISHR meeting in Japan?

Check out the recent work from Alican Guran,
@k8weeks.bsky.social et al. investigating the role of B56α as a mediator of cardiac responses to β-AR stimulation!

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A recent study found that women undergoing cardiac surgery show reduced CD39/CD73 expression and greater #fibrosis. Using a #CD39 mimetic and #CD73 enhancer improved cardiac function and reduced fibrosis in an ovariectomy + high-fat diet mouse model.

Read more: www.sciencedirect.com/science/arti...

Electrophysiological comparison of left versus right stellate ganglia neurons The stellate ganglia of the peripheral autonomic nervous system innervate the heart and continuously fine-tune cardiac function to meet physiological …

New Paper Alert!

New work just published investigated the differences in the #electrophysiology of the left and right stellate ganglia

What repercussions may this have for #Arrhythmia generation?

Congrats to the Authors and thanks to the Reviewers!

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#CardioSky

Exciting news! Join us for another exclusive ISHR-ES webinar: The Beating Edge of Cardiac Metabolism! 🫀💡
📅 Friday, 7th March 2025 | ⏰ 14:00 to15:00 GMT + 1| 💻 Live Online

Hear from three leading experts as they dive into cutting-edge research & innovations.
🔗 Register now: https://buff.ly/4aWIbv1

New research by Grazide and colleagues has revealed a novel biomarker for myocardial infarction risk. Rubicon, a negative regulator of autophagy, could aid in the early detection of individuals at high risk for MI
Read more here: https://buff.ly/3WyWO1i

We are delighted to share that JMCC Plus is now officially indexed in PubMed Central (PMC)! Well done to all the editorial team, particularly our EiC @davorpavlovic.bsky.social and deputy @gundrylab.bsky.social 🎉

Circulating levels of miR-20b-5p are associated with survival in cardiogenic shock Cardiogenic shock (CS) is a medical emergency with high in-hospital mortality. New biomarkers are needed to identify patients at a greater risk of adv…

Can we predict survival after #CardiogenicShock?

New research from researchers at Helsinki University and the Luxembourg Institute of Health show that a particular miRNA (miR-20b-5p) is associated with survival in cardiogenic shock!

#CardioSky