Laura Edgington-Mitchell

Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

18.07.2025 14:40 — 👍 94    🔁 41    💬 4    📌 0

Nuclear Roles for Canonically Lysosomal Proteases While the cysteine proteases legumain and cathepsins have traditionally been known as “lysosomal” proteases, there is increasing evidence to suggest that they also contribute to a wide range of ext...

Congrats to Anna and Marc for the publication of their review article "Nuclear Roles for Canonically Lysosomal Proteases.' Check it here: www.tandfonline.com/doi/full/10.... #LEMLab

22.06.2025 23:34 — 👍 1    🔁 0    💬 0    📌 0

The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below.

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22.05.2025 04:22 — 👍 6    🔁 8    💬 1    📌 1

Cutting the diagnosis journey for children born with rare genetic diseases Families can wait years for a diagnosis of a rare genetic disorder, but a new test can provide answers in days for a better understanding of the condition and potentially earlier treatment, finds new...

We're super proud to see our study showing utility of proteomics in ultra-rapid variant prioritisation for suspected mito and other rare diseases out in Genome Medicine (rdcu.be/endwE). Too many amazing collabs to thank, so here are the big ones @daniellahock.bsky.social @thorburnmito.bsky.social!

23.05.2025 00:57 — 👍 28    🔁 11    💬 1    📌 5

Vergent Bioscience Presents Phase 2B VISUALIZE Results Demonstrating Abenacianine for Injection (VGT-309) with Intraoperative Molecular Imaging Improved Tumor Visualization During Lung Surgery | Verge...

The phase IIb results from the multi center trail of our cathepsin probe (VGT-309/abenacianine) are out. The probe met its endpoints and resulted in significant clinical events in 45% of patients. Great work by Vergent Biosciences and Dr. Sunil Singhal (UPenn).

www.vergentbio.com/press-releas...

22.05.2025 21:36 — 👍 18    🔁 2    💬 2    📌 0

Travel: protease.org/travel-awards

Young Investigator: protease.org/young-invest...

Register for the meeting and workshop: ipsbrazil.com.br

Apply for IPS membership: protease.org/membership

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22.05.2025 04:22 — 👍 0    🔁 0    💬 0    📌 0

We have travel awards available for early career researchers, and we are seeking nominations for the Ulrich auf dem Keller Young Investigator award for researchers within 6 years of establishing their independent labs. Please apply before June 30 so you don't miss out!

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22.05.2025 04:22 — 👍 2    🔁 1    💬 1    📌 0

The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below.

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22.05.2025 04:22 — 👍 6    🔁 8    💬 1    📌 1

Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...

We also show that Coxiella incites the extracellular secretion of lysosomal content in a T4SS independent manner.

A wonderfully enjoyable collaboration with @lauraem-lab.bsky.social & @hayleyjnewton.bsky.social labs (with significant mass spec guidance from @nickescott.bsky.social!)

25.04.2025 00:14 — 👍 6    🔁 1    💬 0    📌 0

Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...

Excited to share this story from my PhD, out today in Nature Communications! We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB.

www.nature.com/articles/s41...

25.04.2025 00:14 — 👍 24    🔁 4    💬 2    📌 3

I'm excited to share the next issue of QuickCuts reporting news from the… | Laura Edgington-Mitchell I'm excited to share the next issue of QuickCuts reporting news from the International Proteolysis Society. Registration for the next general meeting in Brazil is now open, so don't miss out! ...

www.linkedin.com/posts/laura-...

22.04.2025 10:06 — 👍 1    🔁 1    💬 0    📌 0

Great visit to Melbourne Uni to give a talk and visit with my former PhD student Laura Edgington-Mitchell and her lab.

12.04.2025 04:26 — 👍 15    🔁 1    💬 0    📌 0

Table from page 25 of the proposed restructure of ARC grants. Back text on white background, with the table delineated by a dark blue header row and alternating light and very light blue rows.

The ARC Board has proposed a major shake-up of the National Competitive Grants Program ▶️ www.arc.gov.au/engage-us/co...

I've only skimmed so far, but they propose reducing 13 grant schemes to 6, with intent & scope in the table👇

Submissions are being accepted in response until 13 April. Get to it!

25.02.2025 03:45 — 👍 68    🔁 53    💬 15    📌 15