Martín Estermann

From Shosei Yoshida's beautiful talk @ssrepro.bsky.social. Differentiation waves in mouse seminiferous tubules (Stra-8 eGFP). Absolutely spectacular👏 #ReproRocks #ComplexSystems #Microscopy

✨Unexpected but beautiful! 🔬
4 hpf zebrafish embryos injected with BFP 🔵, GFP,🟢 and RFP🔴 mRNAs (1:1:1) showed mosaic, multicolor expression, resembling a brainbow without any genetic recombination 🧬🌈 image taken by A.J. Treichel 
#FluorescenceFriday #Zebrafish #DevBio

Lovely work by @martinestermann.bsky.social and colleagues from the Capel lab! Together with our recent work (www.biorxiv.org/content/10.1...), this really makes a strong case that lactate is crucial to supporting male germ cells in vivo - from flies to mammals.

🚨 New preprint alert! 🚨
Excited to share the preprint that marks the beginning of my journey into the world of metabolism! 🍭🧬
A new chapter exploring how metabolic pathways shape gonadal development.
There’s more to come, stay tuned!
#DevelopmentalBiology #Metabolism

🐌💫 Snail embryos never looked so fabulous!
Tubulin (white), phospho-histone H3 (pink), and F-Actin (cyan) light up this early stage like a cytoskeletal disco ball.
Image from Clemens Cabernard & Adam von Barnau Sythoff 🪩🧬 #FluorescenceFriday

🐣✨ TUJ1 staining reveals the forming trigeminal ganglion in a chick embryo! Image taken by Rocio Márquez from @pstrobl.bsky.social lab, where they investigate how neural crest and placode cells communicate during the formation of this sensory structure 🔬🧪
#FluorescenceFriday

LASDB board meeting during the @socdevbio.bsky.social / @isdb.bsky.social / LASDB joint meeting in San Juan, PR 🌴✨! We’re excited for what’s ahead for developmental biology and the growing role of Latinx scientists in the field. 💪🏽🧬 🐸🐟🐣🐭🪰 #DevBio #LatinxInScience #LASDB #LatinxDB

My first light sheet scanning with a #zebrafish 🩷 embryo! #devBio
#microscopy🎉

4/
🎉 Proud to share this work with co-first author Paula Brown and the Yao lab.
Big thanks to the Mouse Model Core for making this possible! Use it. Share it. Build with it.
🧬 #DevBio #ReproSci

3/
Our model shows:
✅ High specificity for interstitial cells
✅ Activity in embryonic and adult reproductive tissues
✅ No recombination in Sertoli, granulosa, or germ cells
✅ Can also label Nr2f2+ lineages in other organs (lung, kidney)

2/
Most Cre lines used in gonadal research focus on supporting or germ cells.
The interstitium? Often neglected, despite its essential roles in steroidogenesis, structural support, and signaling.
We wanted to fix that. 🧬

🧵1/
🚨 New tool for reproductive biology!
We generated a Nr2f2-iCreERT2 mouse—an inducible Cre model that specifically targets interstitial cells in both male and female gonads.
Read more in our new @biolreprod paper:
🔗 doi.org/10.1093/biol...

🧠✨ E14 mouse embryo lighting up with neural progenitors!
Nestin (⚪️), p73 (🟢), and Tbr2 (🔴) mark distinct progenitor populations shaping the nervous system.
Vishal Lolam is investigating how their balance is disrupted in neurodevelopmental disorders.
#FluorescenceFriday

One of my favourite IF images is participating for the #SSR 2nd Annual #ReproBioArt Image Contest!
Mind helping with a vote?

⬇️

woobox.com/2poyka/galle...

Sugar is usually thought of as a cellular fuel, but it also changes how cells differentiate. preLighter (@prelights.bsky.social) @martinestermann.bsky.social shows that metabolites, such as sugars, influence the development of sex organs—ovaries & testes. Sweet story!

#2025SDB #2025SDB #ICDB2025

🎆🧬 Fireworks in the making!
At 3 days, Nematostella vectensis is already producing stinging cells across its body. These genes (🩷💛💙) cluster in the tentacle tips and across the sea anemone juvenile body 🪼✨ image provided by @gelatinoussting.bsky.social #FluorescenceFriday #DevBio

✨#FluorescenceFriday brings you a glowing Berghia stephanieae juvenile! This stunning sea slug is lit up with Anti-α-Tubulin 🟢, revealing the dense network of cilia that help it glide across surfaces. 🐌💫 Image taken by @Luiza-O-Saad.bsky.social
#Microscopy #DevBio

This is figure 1, which shows iron-metabolism pathways are uniquely activated in embryonic gonads during male sex determination.

Iron deficiency in pregnant mice may lead to the development of ovaries in a small proportion of offspring carrying XY chromosomes, which typically determine male sex, according to a study in Nature. go.nature.com/45FjiTK 🧪

Got stunning fluorescence microscopy images? 🌈🔬 SDB wants to feature YOUR work for #FluorescenceFriday! We highlight images from SDB members with a short description and the image creators 📸. Fill out the form to be featured: forms.gle/gf7Lid9fXcmb... 🧪

🦋✨ #FluorescenceFriday meets developmental biology!
This glowing "butterfly" isn't an insect, it's a transverse section of a developing chicken gonad. When art meets science, even sex differentiation takes flight! Image taken by @martinestermann.bsky.social #ChickenModel #DevBio 🐥🔬

Got stunning fluorescence microscopy images? 🌈🔬 @SDBiology wants to feature YOUR work for #FluorescenceFriday! We highlight images from SDB members with a short description and the image creators 📸. Fill out the form to be featured: forms.gle/gf7Lid9fXcmb... 🧪

A tiny reef builder lighting up the ocean 🪸. This 1-month-old rice coral (Montipora capitata) glows 🟢 with natural GFP and 🟣 with symbiotic algae 🔬. Image taken by Emma Rangel-Huerta
#FluorescenceFriday #ScienceArt #DevBio

Congrats! Happy to see this story finally published!

Behold a mouse blastocyst: The earliest glimpse of a mammal’s first cell fate decision!
Green marks future placenta cells.
Red highlights cells fated to become the embryo. Image taken by @VirginiaSavy.bsky.social
#FluorescenceFriday #DevBio #MouseEmbryo #CellFate #ImagingScience 🧪

Keystone Symposium - Metabolic and Nutritional Control of Development and Cell Fate - preLights The field of developmental metabolism seeks to understand how nutrient availability and the regulation of metabolic pathways support and influence critical biological processes such as tissue patterni...

Missed the #KSMetabDev25 meeting? #KeystoneSymp

@martinestermann.bsky.social & virginiasavy.bsky.social have listed the #preprints that were discussed.

Check out their #preList ⬇️👀
prelights.biologists.com/prelists/ksm...

The deadline to registre for the 20th International Congress of Developmental Biology in Sheraton Puerto Rico, San Juan, PR is on the 21st of May.
The meeting is co-chaired by Marianne Bronner, Carole LaBonne, and Juan Riesgo. More information here:
www.sdbonline.org/2025icdb

Keystone Symposium - Metabolic and Nutritional Control of Development and Cell Fate - preLights The field of developmental metabolism seeks to understand how nutrient availability and the regulation of metabolic pathways support and influence critical biological processes such as tissue patterni...

Together with @virginiasavy.bsky.social, we curated a preList of preprints presented at the Keystone Symposia: Metabolic and Nutritional Control of Development and Cell Fate!
Explore the latest in the field, fresh from the conference! 📑🆕: prelights.biologists.com/prelists/ksm...
#DevBio #Metabolism

Thrilled to see my images featured in this IRP NIH blog post! irp.nih.gov/blog/post/20... ✨🔬🎨📸

While they look pretty, both were actually used to expand our understanding of testicular biology and male fertility. Check out our research here: www.nature.com/articles/s41...

Red nuclei and a glowing green lateral line—zebrafish never disappoint under the scope! Sensory biology meets stunning visuals. Image by Marycruz Flores @mary-flores.bsky.social 🐟🔬
#FluorescenceFriday #Zebrafish #Microscopy #ScienceArt

Day 2 of the Metabolic & Nutritional Control of Development & Cell Fate conference is electric! Celebrate our Future of Science Fund scholars: @jennabergmann.bsky.social, @martinestermann.bsky.social, and Alba Villaronga Luque. Discover Keystone scholarships: keysym.us/scholarships... #KSMetabDev25