Kyla Ost

New Assistant Professor: Tenure Track - Fungal Biology/Medical Mycology - Minneapolis, Minnesota job with University of Minnesota - Medical School | 12848307 About the Job: The Department of Microbiology & Immunology and the Institute on Infectious Diseases (UMIID) at the University of Minnesota Medical ...

Fungal friends: The University of Minnesota is hiring a tenure track medical mycologist, with emphasis on emergence of pathogens, genomics and evolution!

www.nature.com/naturecareer...

Congratulations to the whole team! So exciting to see this out!

Commensal yeast promotes Salmonella Typhimurium virulence - Nature Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.

Excited to share our new publication, out today in Nature! www.nature.com/articles/s41.... @kanchanj.bsky.social led this fascinating fungal-bacterial interaction project. We are grateful for our wonderful collaborators Brian Peters and David Underhill.

ASM, ASBMB, ASCB & FASEB are deeply disappointed in the Supreme Court ruling allowing cancellation of $800M in NIH grants, threatening labs, jobs, and early-career scientists. Stable funding is vital for U.S. science.

Read more: www.ascb.org/society-news...

From novice to expert: preparing your peer review | mBio Peer review is the process that academic journals, conferences, and funding agencies use to ensure the quality of scholarly work before it is published, presented, or funded. Reviewers for academic jo...

"From novice to expert: preparing your peer review"

Worth a read! #microsky

Schematic of TN-seq in C. neoformans. Top left: Transposon insertions (orange arrow) into nonessential genes results in viable cells. In contrast, insertions into essential genes will result in dead and nonrecoverable cells. Top right: TN-seq works by generating a library of cells where each cell has a single independent transposon insertion in a random location. As in A, those insertions into essential regions cause the cells to die and are nonrecoverable. As a result, the total library (bottom) is depleted in insertions in essential regions. Bottom: The Ac/Ds transposon was split into an Ac transposase and a Ds transposon containing a neomycin resistance marker. This Ds transposon was integrated into an intron of URA5 and the Ac transposase was integrated into the safe haven locus. The resulting stain is ura− and neomycin resistant. Upon initiating transposition via growth on galactose, the strain becomes URA+ and mutant at another locus (depicted here as YFG1).

#Fungal infections are hard to treat due to #DrugResistance. @blakebillmyre.bsky.social &co use a high-throughput #TNseq system in #Cryptococcus neoformans to identify >1400 essential genes & reveal a role for #mitochondrial genes in #fluconazole sensitivity @plosbiology.org 🧪 plos.io/4dz3iVm

IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity The mammalian endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1α (IRE1α) is essential for cellular homeostasis and plays key roles …

www.sciencedirect.com/science/arti... @drbadbug.bsky.social @teresaomeara.bsky.social Overall, our findings illustrate non-canonical IRE1α activation during infection and a function for IRE1α in supporting organelle contact sites to safeguard against rapidly growing microbes.

Excited to announce Duke’s inaugural Climate and Fungi Symposium May 16, 2025! Please register for in-person or virtual 🍄 mgm.duke.edu/about-mgm/se...

Cartoon showing a woman looking in to a microscope saying "Whoaah!!!" The caption states "The best part of Science is knowing, for a moment, something that nobody else in the world knows"

A reminder in these hard times. #sciencestrong

Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development Loss of early-life microbial diversity is correlated with diabetes, yet mechanisms by which microbes influence disease remain elusive. We report a critical neonatal window in mice when microbiota disr...

#EveryCellIsAnImmuneCell! June Round &friends show @science.org that in early life bacteria & fungi cooperate to expand insulin producing β islets via macrophage infiltration & that recognition of commensal yeast cell wall can protects against diabetes in adults! www.science.org/doi/10.1126/...

Join us for this month's #MycoTalks with Rebecca Shapiro and Guilhem Janbon

📅Thursday 27 March
🕓16:00 GMT

Register here: universityofexeter.zoom.us/webinar/regi...

Early life colonization with an understudied Candida species promotes long term metabolic health. This still blows my mind - congrats Jen and team! Thrilled to have played a very smal part (mostly as your fungal cheerleader)

PhD studentship for UK citizens! Understand how Endosymbionts Impact Mucoralean Fungi Drug Resistance Profiles. These are devastating invasive fungal infections that need urgent research. Work with my team @mrccmm.bsky.social, @forestcita.bsky.social, and UKDSTL
www.surrey.ac.uk/bbsrc-wessex...

Great summary of the history of progress. Let’s not go quietly back to the dark ages.

Stress-driven emergence of heritable non-genetic drug resistance Drug resistance is the chief cause of treatment failure for therapies targeting chronic and infectious diseases. Whether the emergence of resistance is accelerated by environmental exposure to low lev...

Excited to share my postdoc work now on bioRxiv!

www.biorxiv.org/content/10.1...

We discovered a non-genetic drug-adapted state that emerges frequently in the the human fungal pathogen Candida albicans.

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Congratulations! Excited for the Gokhale lab!

#LocationLocationLocation! Gribonika, Belkaid &co shows @ Nature that skin colonization by Staph epi activates Langerhans cells driving Abs in lymph nodes, & also in skin autonomous lymphoid organs that independently produce Abs protecting against systemic infections! www.nature.com/articles/s41...

Assistant Professor in Fungal Biology University of California, Riverside is hiring. Apply now!

My department is hiring a fungal biologist! aprecruit.ucr.edu/JPF01990

Dr. James Andrew Alspaugh Named Chief of Infectious Diseases Division James Andrew “Andy” Alspaugh, MD, has been appointed as the new chief for the Division of Infectious Diseases, effective December 9, 2024.

Huge congratulations to my PhD advisor! So excited for him and Duke ID medicine.duke.edu/news/dr-jame...

Microbial people! Especially postdocs and maybe some assistant professors who are feeling antsy ... the University of Montana is doing a search for a microbiologist! This is a great department, in a great place. (I worked there for 10 years, loved it, ping me with Qs)

apply.interfolio.com/159494

Please add me! Excellent list